Multiple Sclerosis Journal - October 2017 - i

EDItORIAl
1436 Aerobic exercise, cognitive behavioural therapy and energy
conservation management for multiple sclerosis (MS) fatigue:
Are three trials better than one?
R Moss-Morris and S Norton

1506

Infection-related health care utilization among people with
and without multiple sclerosis
JMA Wijnands, E Kingwell, F Zhu, et al.

1517

Does aerobic training alleviate fatigue and improve societal
participation in patients with multiple sclerosis? A
randomized controlled trial
M Heine, O Verschuren, ELJ Hoogervorst, et al., on behalf of
the TREFAMS-ACE study group

1527

Effectiveness of energy conservation management on fatigue
and participation in multiple sclerosis: A randomized
controlled trial
LJM Blikman, J van Meeteren, JWR Twisk, et al.; TREFAMSACE study group

1542

Cognitive behavioral therapy positively affects fatigue in
patients with multiple sclerosis: Results of a randomized
controlled trial
LE van den Akker, H Beckerman, EH Collette, et al.;
TREFAMS-ACE Study Group

tOPICAl REVIEw
1442 Science is 1% inspiration and 99% biomarkers
N Dubuisson, F Puentes, G Giovannoni and S Gnanapavan
CONtROVERSIES IN MultIPlE SClEROSIS
1454 Advanced MRI measures like DtI or fMRI should be
outcome measures in future clinical trials - YES
R Kapoor
1456

Advanced MRI measures like DtI or fMRI should be
outcome measures in future clinical trials - NO
PM Matthews

1458

Advanced MRI measures like DtI or fMRI should be
outcome measures in future clinical trials - Commentary
N De Stefano and A Giorgio

ORIGINAl RESEARCh PAPERS
1461 large differences in adiponectin levels have no clear effect on
multiple sclerosis risk: A Mendelian randomization study
J Devorak, LE Mokry, JA Morris, et al.
1469

translocator positron-emission tomography and magnetic
resonance spectroscopic imaging of brain glial cell activation
in multiple sclerosis
G Datta, IR Violante, G Scott, et al.

1479

Natural killer cell subpopulations are associated with MRI
activity in a relapsing-remitting multiple sclerosis patient
cohort from Australia
P Caruana, K Lemmert, K Ribbons, R Lea and J Lechner-Scott

1488

Clinical course of multiple sclerosis: A nationwide cohort
study
A Manouchehrinia, O Beiki and J Hillert

1496

Prognostic value of free light chains lambda and kappa in
early multiple sclerosis
MM Voortman, T Stojakovic, L Pirpamer, et al.

ShORt REPORt
1554 hispanic Americans and African Americans with multiple
sclerosis have more severe disease course than Caucasian
Americans
RE Ventura, AO Antezana, T Bacon and I Kister
CASE REPORt AND ClINICAl COMMENtARY
1558 Primary progressive multiple sclerosis presenting with severe
predominant cognitive impairment and psychiatric
symptoms: A challenging case
AA Zambon, G Cecchetti, F Caso, et al.
1561

the diagnostic dilemma of multiple sclerosis presenting with
isolated cognitive and behavioral disorders
MP Amato

lEttER
1564 Patient-to-patient transmission of natalizumab-associated
PMl?
R Hohlfeld, J Havla and T Kümpfel

Cover image adapted from Figure 1, in the article, Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of
brain glial cell activation in multiple sclerosis by Gourab Datta, Ines R Violante, Gregory Scott, Karl Zimmerman, Andre Santos-Ribeiro, Eugenii
A Rabiner, Roger N Gunn, Omar Malik, Olga Ciccarelli, Richard Nicholas and Paul M Matthews page 1473.
Affiliated with the Americas Committee for treatment and Research in Multiple Sclerosis (ACtRIMS),
the European Committee for treatment and Research in Multiple Sclerosis (ECtRIMS), the Pan-Asian
Committee for treatment and Research in Multiple Sclerosis (PACtRIMS), the latin American
Committee on treatment and Research of Multiple Sclerosis (lACtRIMS) and Rehabilitation
in Multiple Sclerosis (RIMS). MSJ is the official journal of the European Charcot Foundation.



Table of Contents for the Digital Edition of Multiple Sclerosis Journal - October 2017

Contents
Multiple Sclerosis Journal - October 2017 - Cover1
Multiple Sclerosis Journal - October 2017 - Cover2
Multiple Sclerosis Journal - October 2017 - Contents
Multiple Sclerosis Journal - October 2017 - ii
Multiple Sclerosis Journal - October 2017 - iii
Multiple Sclerosis Journal - October 2017 - 1436
Multiple Sclerosis Journal - October 2017 - 1437
Multiple Sclerosis Journal - October 2017 - 1438
Multiple Sclerosis Journal - October 2017 - 1439
Multiple Sclerosis Journal - October 2017 - 1440
Multiple Sclerosis Journal - October 2017 - 1441
Multiple Sclerosis Journal - October 2017 - 1442
Multiple Sclerosis Journal - October 2017 - 1443
Multiple Sclerosis Journal - October 2017 - 1444
Multiple Sclerosis Journal - October 2017 - 1445
Multiple Sclerosis Journal - October 2017 - 1446
Multiple Sclerosis Journal - October 2017 - 1447
Multiple Sclerosis Journal - October 2017 - 1448
Multiple Sclerosis Journal - October 2017 - 1449
Multiple Sclerosis Journal - October 2017 - 1450
Multiple Sclerosis Journal - October 2017 - 1451
Multiple Sclerosis Journal - October 2017 - 1452
Multiple Sclerosis Journal - October 2017 - 1453
Multiple Sclerosis Journal - October 2017 - 1454
Multiple Sclerosis Journal - October 2017 - 1455
Multiple Sclerosis Journal - October 2017 - 1456
Multiple Sclerosis Journal - October 2017 - 1457
Multiple Sclerosis Journal - October 2017 - 1458
Multiple Sclerosis Journal - October 2017 - 1459
Multiple Sclerosis Journal - October 2017 - 1460
Multiple Sclerosis Journal - October 2017 - 1461
Multiple Sclerosis Journal - October 2017 - 1462
Multiple Sclerosis Journal - October 2017 - 1463
Multiple Sclerosis Journal - October 2017 - 1464
Multiple Sclerosis Journal - October 2017 - 1465
Multiple Sclerosis Journal - October 2017 - 1466
Multiple Sclerosis Journal - October 2017 - 1467
Multiple Sclerosis Journal - October 2017 - 1468
Multiple Sclerosis Journal - October 2017 - 1469
Multiple Sclerosis Journal - October 2017 - 1470
Multiple Sclerosis Journal - October 2017 - 1471
Multiple Sclerosis Journal - October 2017 - 1472
Multiple Sclerosis Journal - October 2017 - 1473
Multiple Sclerosis Journal - October 2017 - 1474
Multiple Sclerosis Journal - October 2017 - 1475
Multiple Sclerosis Journal - October 2017 - 1476
Multiple Sclerosis Journal - October 2017 - 1477
Multiple Sclerosis Journal - October 2017 - 1478
Multiple Sclerosis Journal - October 2017 - 1479
Multiple Sclerosis Journal - October 2017 - 1480
Multiple Sclerosis Journal - October 2017 - 1481
Multiple Sclerosis Journal - October 2017 - 1482
Multiple Sclerosis Journal - October 2017 - 1483
Multiple Sclerosis Journal - October 2017 - 1484
Multiple Sclerosis Journal - October 2017 - 1485
Multiple Sclerosis Journal - October 2017 - 1486
Multiple Sclerosis Journal - October 2017 - 1487
Multiple Sclerosis Journal - October 2017 - 1488
Multiple Sclerosis Journal - October 2017 - 1489
Multiple Sclerosis Journal - October 2017 - 1490
Multiple Sclerosis Journal - October 2017 - 1491
Multiple Sclerosis Journal - October 2017 - 1492
Multiple Sclerosis Journal - October 2017 - 1493
Multiple Sclerosis Journal - October 2017 - 1494
Multiple Sclerosis Journal - October 2017 - 1495
Multiple Sclerosis Journal - October 2017 - 1496
Multiple Sclerosis Journal - October 2017 - 1497
Multiple Sclerosis Journal - October 2017 - 1498
Multiple Sclerosis Journal - October 2017 - 1499
Multiple Sclerosis Journal - October 2017 - 1500
Multiple Sclerosis Journal - October 2017 - 1501
Multiple Sclerosis Journal - October 2017 - 1502
Multiple Sclerosis Journal - October 2017 - 1503
Multiple Sclerosis Journal - October 2017 - 1504
Multiple Sclerosis Journal - October 2017 - 1505
Multiple Sclerosis Journal - October 2017 - 1506
Multiple Sclerosis Journal - October 2017 - 1507
Multiple Sclerosis Journal - October 2017 - 1508
Multiple Sclerosis Journal - October 2017 - 1509
Multiple Sclerosis Journal - October 2017 - 1510
Multiple Sclerosis Journal - October 2017 - 1511
Multiple Sclerosis Journal - October 2017 - 1512
Multiple Sclerosis Journal - October 2017 - 1513
Multiple Sclerosis Journal - October 2017 - 1514
Multiple Sclerosis Journal - October 2017 - 1515
Multiple Sclerosis Journal - October 2017 - 1516
Multiple Sclerosis Journal - October 2017 - 1517
Multiple Sclerosis Journal - October 2017 - 1518
Multiple Sclerosis Journal - October 2017 - 1519
Multiple Sclerosis Journal - October 2017 - 1520
Multiple Sclerosis Journal - October 2017 - 1521
Multiple Sclerosis Journal - October 2017 - 1522
Multiple Sclerosis Journal - October 2017 - 1523
Multiple Sclerosis Journal - October 2017 - 1524
Multiple Sclerosis Journal - October 2017 - 1525
Multiple Sclerosis Journal - October 2017 - 1526
Multiple Sclerosis Journal - October 2017 - 1527
Multiple Sclerosis Journal - October 2017 - 1528
Multiple Sclerosis Journal - October 2017 - 1529
Multiple Sclerosis Journal - October 2017 - 1530
Multiple Sclerosis Journal - October 2017 - 1531
Multiple Sclerosis Journal - October 2017 - 1532
Multiple Sclerosis Journal - October 2017 - 1533
Multiple Sclerosis Journal - October 2017 - 1534
Multiple Sclerosis Journal - October 2017 - 1535
Multiple Sclerosis Journal - October 2017 - 1536
Multiple Sclerosis Journal - October 2017 - 1537
Multiple Sclerosis Journal - October 2017 - 1538
Multiple Sclerosis Journal - October 2017 - 1539
Multiple Sclerosis Journal - October 2017 - 1540
Multiple Sclerosis Journal - October 2017 - 1541
Multiple Sclerosis Journal - October 2017 - 1542
Multiple Sclerosis Journal - October 2017 - 1543
Multiple Sclerosis Journal - October 2017 - 1544
Multiple Sclerosis Journal - October 2017 - 1545
Multiple Sclerosis Journal - October 2017 - 1546
Multiple Sclerosis Journal - October 2017 - 1547
Multiple Sclerosis Journal - October 2017 - 1548
Multiple Sclerosis Journal - October 2017 - 1549
Multiple Sclerosis Journal - October 2017 - 1550
Multiple Sclerosis Journal - October 2017 - 1551
Multiple Sclerosis Journal - October 2017 - 1552
Multiple Sclerosis Journal - October 2017 - 1553
Multiple Sclerosis Journal - October 2017 - 1554
Multiple Sclerosis Journal - October 2017 - 1555
Multiple Sclerosis Journal - October 2017 - 1556
Multiple Sclerosis Journal - October 2017 - 1557
Multiple Sclerosis Journal - October 2017 - 1558
Multiple Sclerosis Journal - October 2017 - 1559
Multiple Sclerosis Journal - October 2017 - 1560
Multiple Sclerosis Journal - October 2017 - 1561
Multiple Sclerosis Journal - October 2017 - 1562
Multiple Sclerosis Journal - October 2017 - 1563
Multiple Sclerosis Journal - October 2017 - 1564
Multiple Sclerosis Journal - October 2017 - 1565
Multiple Sclerosis Journal - October 2017 - 1566
Multiple Sclerosis Journal - October 2017 - Cover3
Multiple Sclerosis Journal - October 2017 - Cover4
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