Multiple Sclerosis Journal - October 2017 - 1448

Multiple Sclerosis Journal 23(11)
Declaration of Conflicting Interests
The author(s) declared the following potential conflicts of interest with respect to the research, authorship and/or publication of this article: N.D. is an
ECTRIMS fellow which is unrelated to the contents
of this publication; F.P. has received research support
from Biogen Idec; G.G. has received compensation
for participating in Advisory Boards in relation with
clinical trial design, trial steering committees, and
data and safety monitoring committees from Abbvie,
Bayer-Schering Healthcare, Biogen Idec, Eisai, Elan,
Fiveprime, Genzyme, Genentech, GSK, GW Pharma,
Ironwood, Merck-Serono, Novartis, Pfizer, Roche,
Sanofi-Aventis, Synthon BV, Teva, UCB Pharma and
Vertex Pharmaceuticals; S.G. has received personal
compensation for activities with Biogen, Genzyme,
Novartis and Teva, and research support from National
MS Society, Genzyme and Takeda.
Funding
The author(s) received no financial support for the
research, authorship and/or publication of this
article.

References
1. Lesko LJ and Atkinson AJ Jr. Use of biomarkers
and surrogate endpoints in drug development and
regulatory decision making: Criteria, validation,
strategies. Annu Rev Pharmacol Toxicol 2001; 41:
347-366.
2. Hill AB. The environment and disease: Association or
causation? Proc R Soc Med 1965; 58: 295-300.
3. Lee D-H, Steinacker P, Seubert S, et al. Role of glial
14-3-3 gamma protein in autoimmune demyelination.
J Neuroinflammation 2015; 12: 187.
4. Bartosik-Psujek H and Archelos JJ. Tau protein
and 14-3-3 are elevated in the cerebrospinal fluid of
patients with multiple sclerosis and correlate with
intrathecal synthesis of IgG. J Neurol 2004; 251(4):
414-420.
5. Colucci M, Roccatagliata L, Capello E, et al. The
14-3-3 protein in multiple sclerosis: A marker of
disease severity. Mult Scler 2004; 10(5): 477-481.
6. Kurnellas MP, Adams CM, Sobel RA, et al. Amyloid
fibrils composed of hexameric peptides attenuate
neuroinflammation. Sci Transl Med 2013; 5(179):
179ra42.
7. Boylan MT, Crockard AD, Duddy ME, et al.
Interferon-β1a administration results in a transient
increase of serum amyloid a protein and C-reactive
protein: Comparison with other markers of
inflammation. Immunol Lett 2001; 75(3): 191-197.

1448

8. Mori F, Rossi S, Sancesario G, et al. Cognitive
and cortical plasticity deficits correlate with
altered amyloid-β CSF levels in multiple sclerosis.
Neuropsychopharmacology 2011; 36(3): 559-568.
9. Bernardes D, Oliveira-Lima OC, Silva TV, et al.
Differential brain and spinal cord cytokine and BDNF
levels in experimental autoimmune encephalomyelitis
are modulated by prior and regular exercise.
J Neuroimmunol 2013; 264(1-2): 24-34.
10. Briken S, Rosenkranz SC, Keminer O, et al. Effects
of exercise on Irisin, BDNF and IL-6 serum levels
in patients with progressive multiple sclerosis.
J Neuroimmunol 2016; 299: 53-58.
11. Wens I, Keytsman C, Deckx N, et al. Brain derived
neurotrophic factor in multiple sclerosis: Effect
of 24 weeks endurance and resistance training.
Eur J Neurol 2016; 23(6): 1028-1035.
12. Tsakiri A, Ravanidis S, Lagoudaki R, et al.
Neuroprotective and anti-inflammatory mechanisms
are activated early in optic neuritis. Acta Neurol
Scand 2015; 131(5): 305-312.
13. Mashayekhi F, Salehi Z and Jamalzadeh HR.
Quantitative analysis of cerebrospinal fluid brain
derived neurotrophic factor in the patients with
multiple sclerosis. Acta Medica 2012; 55(2): 83-86.
14. Azoulay D, Vachapova V, Shihman B, et al. Lower
brain-derived neurotrophic factor in serum of
relapsing remitting MS: Reversal by glatiramer
acetate. J Neuroimmunol 2005; 167(1-2): 215-218.
15. Grygorowicz T, Wełniak-Kamińska M and
Strużyńska L. Early P2X7R-related astrogliosis in
autoimmune encephalomyelitis. Mol Cell Neurosci
2016; 74: 1-9.
16. Gnanapavan S, Grant D, Morant S, et al. Biomarker
report from the phase II lamotrigine trial in secondary
progressive MS - Neurofilament as a surrogate of
disease progression. PLoS ONE 2013; 8(8): e70019.
17. Axelsson M, Malmeström C, Nilsson S, et al. Glial
fibrillary acidic protein: A potential biomarker for
progression in multiple sclerosis. J Neurol 2011;
258(5): 882-888.
18. Martínez MAM, Olsson B, Bau L, et al. Glial and
neuronal markers in cerebrospinal fluid predict
progression in multiple sclerosis. Mult Scler 2015;
21(5): 550-561.
19. Petzold A, Eikelenboom MJ, Gveric D, et al. Markers
for different glial cell responses in multiple sclerosis:
Clinical and pathological correlations. Brain 2002;
125(Pt. 7): 1462-1473.
20. Rosengren LE, Lycke J and Andersen O. Glial
fibrillary acidic protein in CSF of multiple sclerosis
patients: Relation to neurological deficit. J Neurol Sci
1995; 133(1-2): 61-65.

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Table of Contents for the Digital Edition of Multiple Sclerosis Journal - October 2017

Contents
Multiple Sclerosis Journal - October 2017 - Cover1
Multiple Sclerosis Journal - October 2017 - Cover2
Multiple Sclerosis Journal - October 2017 - Contents
Multiple Sclerosis Journal - October 2017 - ii
Multiple Sclerosis Journal - October 2017 - iii
Multiple Sclerosis Journal - October 2017 - 1436
Multiple Sclerosis Journal - October 2017 - 1437
Multiple Sclerosis Journal - October 2017 - 1438
Multiple Sclerosis Journal - October 2017 - 1439
Multiple Sclerosis Journal - October 2017 - 1440
Multiple Sclerosis Journal - October 2017 - 1441
Multiple Sclerosis Journal - October 2017 - 1442
Multiple Sclerosis Journal - October 2017 - 1443
Multiple Sclerosis Journal - October 2017 - 1444
Multiple Sclerosis Journal - October 2017 - 1445
Multiple Sclerosis Journal - October 2017 - 1446
Multiple Sclerosis Journal - October 2017 - 1447
Multiple Sclerosis Journal - October 2017 - 1448
Multiple Sclerosis Journal - October 2017 - 1449
Multiple Sclerosis Journal - October 2017 - 1450
Multiple Sclerosis Journal - October 2017 - 1451
Multiple Sclerosis Journal - October 2017 - 1452
Multiple Sclerosis Journal - October 2017 - 1453
Multiple Sclerosis Journal - October 2017 - 1454
Multiple Sclerosis Journal - October 2017 - 1455
Multiple Sclerosis Journal - October 2017 - 1456
Multiple Sclerosis Journal - October 2017 - 1457
Multiple Sclerosis Journal - October 2017 - 1458
Multiple Sclerosis Journal - October 2017 - 1459
Multiple Sclerosis Journal - October 2017 - 1460
Multiple Sclerosis Journal - October 2017 - 1461
Multiple Sclerosis Journal - October 2017 - 1462
Multiple Sclerosis Journal - October 2017 - 1463
Multiple Sclerosis Journal - October 2017 - 1464
Multiple Sclerosis Journal - October 2017 - 1465
Multiple Sclerosis Journal - October 2017 - 1466
Multiple Sclerosis Journal - October 2017 - 1467
Multiple Sclerosis Journal - October 2017 - 1468
Multiple Sclerosis Journal - October 2017 - 1469
Multiple Sclerosis Journal - October 2017 - 1470
Multiple Sclerosis Journal - October 2017 - 1471
Multiple Sclerosis Journal - October 2017 - 1472
Multiple Sclerosis Journal - October 2017 - 1473
Multiple Sclerosis Journal - October 2017 - 1474
Multiple Sclerosis Journal - October 2017 - 1475
Multiple Sclerosis Journal - October 2017 - 1476
Multiple Sclerosis Journal - October 2017 - 1477
Multiple Sclerosis Journal - October 2017 - 1478
Multiple Sclerosis Journal - October 2017 - 1479
Multiple Sclerosis Journal - October 2017 - 1480
Multiple Sclerosis Journal - October 2017 - 1481
Multiple Sclerosis Journal - October 2017 - 1482
Multiple Sclerosis Journal - October 2017 - 1483
Multiple Sclerosis Journal - October 2017 - 1484
Multiple Sclerosis Journal - October 2017 - 1485
Multiple Sclerosis Journal - October 2017 - 1486
Multiple Sclerosis Journal - October 2017 - 1487
Multiple Sclerosis Journal - October 2017 - 1488
Multiple Sclerosis Journal - October 2017 - 1489
Multiple Sclerosis Journal - October 2017 - 1490
Multiple Sclerosis Journal - October 2017 - 1491
Multiple Sclerosis Journal - October 2017 - 1492
Multiple Sclerosis Journal - October 2017 - 1493
Multiple Sclerosis Journal - October 2017 - 1494
Multiple Sclerosis Journal - October 2017 - 1495
Multiple Sclerosis Journal - October 2017 - 1496
Multiple Sclerosis Journal - October 2017 - 1497
Multiple Sclerosis Journal - October 2017 - 1498
Multiple Sclerosis Journal - October 2017 - 1499
Multiple Sclerosis Journal - October 2017 - 1500
Multiple Sclerosis Journal - October 2017 - 1501
Multiple Sclerosis Journal - October 2017 - 1502
Multiple Sclerosis Journal - October 2017 - 1503
Multiple Sclerosis Journal - October 2017 - 1504
Multiple Sclerosis Journal - October 2017 - 1505
Multiple Sclerosis Journal - October 2017 - 1506
Multiple Sclerosis Journal - October 2017 - 1507
Multiple Sclerosis Journal - October 2017 - 1508
Multiple Sclerosis Journal - October 2017 - 1509
Multiple Sclerosis Journal - October 2017 - 1510
Multiple Sclerosis Journal - October 2017 - 1511
Multiple Sclerosis Journal - October 2017 - 1512
Multiple Sclerosis Journal - October 2017 - 1513
Multiple Sclerosis Journal - October 2017 - 1514
Multiple Sclerosis Journal - October 2017 - 1515
Multiple Sclerosis Journal - October 2017 - 1516
Multiple Sclerosis Journal - October 2017 - 1517
Multiple Sclerosis Journal - October 2017 - 1518
Multiple Sclerosis Journal - October 2017 - 1519
Multiple Sclerosis Journal - October 2017 - 1520
Multiple Sclerosis Journal - October 2017 - 1521
Multiple Sclerosis Journal - October 2017 - 1522
Multiple Sclerosis Journal - October 2017 - 1523
Multiple Sclerosis Journal - October 2017 - 1524
Multiple Sclerosis Journal - October 2017 - 1525
Multiple Sclerosis Journal - October 2017 - 1526
Multiple Sclerosis Journal - October 2017 - 1527
Multiple Sclerosis Journal - October 2017 - 1528
Multiple Sclerosis Journal - October 2017 - 1529
Multiple Sclerosis Journal - October 2017 - 1530
Multiple Sclerosis Journal - October 2017 - 1531
Multiple Sclerosis Journal - October 2017 - 1532
Multiple Sclerosis Journal - October 2017 - 1533
Multiple Sclerosis Journal - October 2017 - 1534
Multiple Sclerosis Journal - October 2017 - 1535
Multiple Sclerosis Journal - October 2017 - 1536
Multiple Sclerosis Journal - October 2017 - 1537
Multiple Sclerosis Journal - October 2017 - 1538
Multiple Sclerosis Journal - October 2017 - 1539
Multiple Sclerosis Journal - October 2017 - 1540
Multiple Sclerosis Journal - October 2017 - 1541
Multiple Sclerosis Journal - October 2017 - 1542
Multiple Sclerosis Journal - October 2017 - 1543
Multiple Sclerosis Journal - October 2017 - 1544
Multiple Sclerosis Journal - October 2017 - 1545
Multiple Sclerosis Journal - October 2017 - 1546
Multiple Sclerosis Journal - October 2017 - 1547
Multiple Sclerosis Journal - October 2017 - 1548
Multiple Sclerosis Journal - October 2017 - 1549
Multiple Sclerosis Journal - October 2017 - 1550
Multiple Sclerosis Journal - October 2017 - 1551
Multiple Sclerosis Journal - October 2017 - 1552
Multiple Sclerosis Journal - October 2017 - 1553
Multiple Sclerosis Journal - October 2017 - 1554
Multiple Sclerosis Journal - October 2017 - 1555
Multiple Sclerosis Journal - October 2017 - 1556
Multiple Sclerosis Journal - October 2017 - 1557
Multiple Sclerosis Journal - October 2017 - 1558
Multiple Sclerosis Journal - October 2017 - 1559
Multiple Sclerosis Journal - October 2017 - 1560
Multiple Sclerosis Journal - October 2017 - 1561
Multiple Sclerosis Journal - October 2017 - 1562
Multiple Sclerosis Journal - October 2017 - 1563
Multiple Sclerosis Journal - October 2017 - 1564
Multiple Sclerosis Journal - October 2017 - 1565
Multiple Sclerosis Journal - October 2017 - 1566
Multiple Sclerosis Journal - October 2017 - Cover3
Multiple Sclerosis Journal - October 2017 - Cover4
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