G Datta, IR Violante et al. Figure 3. Correlations of neurodegeneration measures with [11C]PBR28 distribution volume ratio (DVR). (a) The normalised concentration of N-acetyl aspartate (NAA) was negatively correlated with the average DVR in T2 FLAIR white matter lesions (Spearman's ρ = −0.443, p = 0.034). (b) The whole brain normalised grey matter volume was correlated with DVR of white matter lesions within the spectroscopy volume weighted by the white matter lesion tissue fraction (ρ = −0.535, p = 0.009). The dashed line is the regression line and black dots describe data from different patients (n = 23). between the whole brain normalised grey matter volume, as a measure of relative neurodegeneration, and [11C]PBR28 DVR weighted by WML fraction in the spectroscopy voxel (ρ = −0.535, p = 0.009, journals.sagepub.com/home/msj Figure 3(b)). There was no evidence for correlations between myo-inositol and either NAA (ρ = 0.238, p = 0.274) or the normalised whole brain grey matter volume (ρ = −0.205 and p = 0.349). We did not find 1475https://journals.sagepub.com/home/msj