Multiple Sclerosis Journal 23(11) Table 5. Results of the linear mixed model analyses for secondary outcomes. Crude model CIS20r Concentration CIS20r Motivation CIS20r Physical activity CIS20r Total MFIS Physical MFIS Cognitive MFIS Psychosocial MFIS Total FSS SF-36 Physical function SF-36 Role physical SF-36 Body pain SF-36 General health SF-36 Vitality SF-36 Social function SF-36 Role emotional SF-36 Mental health RAP Communication RAP Mobility RAP Self-care RAP Occupation RAP Relationships Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Overall Adjusted modela B p 95% CI 0.36 −1.00 −0.57 −2.03 −0.01 −0.22 0.08 −0.13 0.04 2.37 −1.00 −1.43 3.01 −0.22 −1.63 −0.05 0.61 0.01 0.21 −0.10 −0.26 −0.11 0.77 0.18 0.38 0.52 0.99 0.85 0.76 0.95 0.76 0.37 0.87 0.64 0.14 0.93 0.56 0.99 0.79 0.92 0.52 0.73 0.27 0.55 −2.03 −2.47 −1.86 −8.33 −2.03 −2.49 −0.44 −4.55 −0.22 −2.81 −12.94 −7.40 −1.05 −4.94 −7.22 −11.84 −3.97 −0.17 −0.44 −0.69 −0.73 −0.48 2.74 0.47 0.72 4.28 2.00 2.06 0.61 4.30 0.30 7.55 10.95 4.56 7.07 4.49 3.96 11.74 5.19 0.19 0.86 0.48 0.21 0.26 B p 95% CI 0.44 −1.03 −0.60 −1.92 0.08 −0.02 0.13 0.20 0.03 2.22 −1.33 −1.25 2.85 −0.17 −2.15 0.69 0.67 0.01 0.24 −0.08 −0.24 −0.11 0.72 0.16 0.37 0.55 0.93 0.98 0.62 0.93 0.82 0.40 0.83 0.69 0.18 0.94 0.44 0.91 0.78 0.89 0.47 0.78 0.31 0.56 −2.00 −2.49 −1.93 −8.33 −1.89 −2.31 −0.39 −4.17 −0.23 −3.06 −13.46 −7.41 −1.31 −4.99 −7.72 −11.55 −4.06 −0.17 −0.43 −0.66 −0.70 −0.48 2.88 0.42 0.72 4.49 2.06 2.27 0.66 4.58 0.28 7.50 10.80 4.91 7.00 4.64 3.42 12.94 5.40 0.20 0.91 0.50 0.22 0.26 CI: confidence interval; CIS20r: Checklist Individual Strength; MFIS: Modified Fatigue Impact Scale; FSS: Fatigue Severity Scale; SF-36: health-related quality of life; RAP: Rehabilitation Activities Profile. Crude analyses are adjusted for the baseline value of the particular outcome. aAdjusted for centre, gender, exacerbations and time since diagnosis. Table 6. Results of linear mixed model analysis for time-specific intervention effects of the secondary outcomes. Crude model CIS20r Concentration CIS20r Motivation CIS20r Physical activity CIS20r Total 1536 T8 T16 T26 T52 T8 T16 T26 T52 T8 T16 T26 T52 T8 T16 T26 T52 Adjusted modela B p 95% CI 0.42 0.96 0.30 −0.37 −0.24 −0.64 −2.26 −0.97 0.09 −0.18 −1.42 −0.92 2.93 −1.26 −6.97 −3.75 0.77 0.52 0.84 0.80 0.82 0.55 0.03 0.36 0.92 0.84 0.11 0.31 0.48 0.76 0.10 0.38 −2.43 −1.94 −2.60 −3.29 −2.27 −2.71 −4.34 −3.07 −1.61 −1.91 −3.16 −2.67 −5.17 −9.54 −15.24 −12.11 3.27 3.86 3.20 2.55 1.79 1.44 −0.19 1.13 1.79 1.56 0.31 0.84 11.03 7.01 1.31 4.60 B p 95% CI 0.49 1.03 0.40 −0.26 −0.25 −0.68 −2.32 −1.01 0.05 −0.21 −1.46 −0.94 3.03 −1.27 −6.88 −3.62 0.74 0.49 0.79 0.86 0.81 0.52 0.03 0.34 0.95 0.81 0.10 0.30 0.47 0.77 0.11 0.40 −2.40 −1.92 −2.54 −3.23 −2.27 −2.76 −4.40 −3.11 −1.67 −1.98 −3.23 −2.73 −5.14 −9.63 −15.24 −12.05 3.38 3.98 3.35 2.71 1.77 1.39 −0.25 1.08 1.78 1.55 0.31 0.84 11.19 7.09 1.48 4.82 journals.sagepub.com/home/msjhttps://journals.sagepub.com/home/msj