Multiple Sclerosis Journal - October 2017 - 1453

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Therapeutic Targets in MS: The frontier and
the future of disease modifying therapy

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Session 1 - Emerging concepts in MS

Theme: This session will highlight cutting edge studies that:
(i) inform our understanding of pathogenic mechanisms in MS;
(ii) introduce novel outcome measures to capture disease activity;
and (iii) advance treatment options for affected individuals. It will
be comprised of platform presentations by young investigators
selected from submitted abstracts.

Session 2 - The blood-brain barrier

Theme: Blood-brain barrier (BBB) breakdown is an early event in
the formation of MS lesions. This session will provide an overview
of BBB physiology and how it is interrupted during MS. The
mechanisms of action of current disease modifying therapies
that affect the BBB will be examined. Novel adhesion molecules,
that may be targeted in the future, will be discussed.

Session 3 - Lymphocytes
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Theme: T cells have been implicated in the pathogenesis of MS
by GWAS, histological analyses of MS lesions and animal model
studies. An important role of B cells was recently demonstrated
by successful clinical trials of B cell depleting agents in MS. This
session will provide a review of our current understanding of the
roles of T and B cells in the development of MS lesions. Clinical
trial data, and putative mechanisms of action, of lymphocyte
modulating therapies in MS will be discussed.

Session 4 - Microglia and macrophages

Theme: The ontogeny and biology of microglia will be reviewed.
Recent discoveries about the beneficial and destructive effects of
microglia and macrophages during inflammatory demyelinating
disease will be discussed.

Session 5 - Astrocytes

Theme: A general overview of astrocyte biology will be given.
Cutting edge research on the heterogeneity of astrocytes and
their contribution to lesion progression and resolution in MS will
be discussed.

Session 6 - Oligodendrocytes and their precursors

Theme: Chronic disability in MS may be due in part to a failure
of oligodendrocyte differentiation and remyelination. The focus
of this session is novel strategies for promoting these processes
in patients.

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Table of Contents for the Digital Edition of Multiple Sclerosis Journal - October 2017
