1550 −7.19 (−11.13; −3.25) −0.09 (−0.29; 0.11) 0.06 (−0.19; 0.31) −0.19 (−0.43; 0.05) 0.04 (−0.15; 0.22) −0.12 (−0.43; 0.19) −0.46 (−0.83; −0.10) −5.45 (−10.70; −0.20) −2.72 (−5.32; −0.12) −2.47 (−5.15; 0.21) −0.66 (−1.39; 0.07) −13.91 (−22.31; −5.52) −1.30 (−4.18; 1.58) −1.99 (−4.36; 0.39) −2.13 (−4.14; −0.11) 9.56 (3.10; 16.01) 4.63 (−0.86; 10.12) 2.75 (−5.03; 10.53) −3.71 (−9.01; 1.58) 24.49 (7.66; 41.32) 12.91 (−3.86; 29.69) 2.31 (−5.79; 10.42) 2.26 (−3.76; 8.29) 0.12 (−0.26; 0.49) 0.07 (−0.92; 1.07) −0.75 (−2.05; 0.54) −1.08 (−2.39; 0.23) 0.18 (−0.50; 0.86) −4.22 (−7.11; −1.33) −0.05 (−0.21; 0.11) −0.05 (−0.25; 0.15) −0.14 (−0.32; 0.05) 0.05 (−0.10; 0.21) −0.15 (−0.35; 0.06) −0.39 (−0.67; −0.12) −1.65 (−5.70; 2.40) −0.26 (−2.30; 1.79) −1.49 (−3.53; 0.54) −0.01 (−0.56; 0.53) −8.16 (−14.55; −1.77) −0.95 (−3.30; 1.40) −1.20 (−3.10; 0.70) −1.08 (−2.64; 0.48) 5.55 (0.52; 10.58) 0.76 (−3.51; 5.03) −0.01 (−5.89; 5.86) −1.51 (−5.30; 2.27) 10.21 (−1.4; 21.46) 5.70 (−5.76; 17.15) −1.56 (−7.61; 4.49) 1.91 (−2.73; 6.55) 0.09 (−0.12; 0.31) 0.26 (−0.48; 1.01) 0.03 (−0.88; 0.94) −0.59 (−1.39; 0.21) 0.14 (−0.39; 0.67) T8 −0.71 (−1.07; −0.34) −3.94 (−9.19; 1.31) −1.80 (−4.39; 0.80) −2.28 (−4.98; 0.42) 0.01 (−0.72; 0.74) −14.35 (−22.84; −5.86) −2.44 (−5.34; 0.47) −2.16 (−4.55; 0.24) −2.46 (−4.49; −0.43) 8.39 (1.85; 14.93) 1.32 (−4.28; 6.92) 2.24 (−5.67; 10.14) −1.44 (−6.81; 3.93) 14.58 (−2.55; 31.71) 5.65 (−11.42; 22.72) −3.33 (−11.60; 4.94) 2.45 (−3.66; 8.56) 0.27 (−0.11;0.64) 0.08 (−1.06;0.91) 0.42 (−0.90;1.74) −0.14 (−1.45;1.17) 0.06 (−0.62;0.74) −6.67 (−10.68; −2.70) −0.13 (−0.33; 0.07) −0.11 (−0.37; 0.14) −0.16 (−0.40; 0.08) 0.08 (−0.11; 0.27) −0.09 (−0.41; 0.22) T16 −0.38 (−0.75; −0.01) −1.29 (−6.58; 4.00) 0.12 (−2.48; 2.72) −1.48 (−4.18; 1.22) 0.24 (−0.50; 0.97) −5.49 (−13.95; 2.96) 0.15 (−2.76; 3.06) −1.09 (−3.49; 1.30) −0.41 (−2.44; 1.62) 5.12 (−1.37; 11.61) 0.22 (−5.31; 5.75) −1.47 (−9.31; 6.36) −0.42 (−5.74; 4.90) 13.63 (−3.32; 30.58) 4.37 (−12.53; 21.26) 0.49 (−7.66; 8.65) 3.62 (−2.44; 9.69) 0.09 (−0.30; 0.48) 0.25 (−0.76; 1.26) 0.50 (−0.85; 1.85) −0.98 (−2.36; 0.40) 0.07 (−0.62; 0.77) −3.46 (−7.43; 0.51) −0.01 (−0.21; 0.19) −0.11 (−0.36; 0.14) −0.22 (−0.46; 0.02) 0.11 (−0.08; 0.30) −0.34 (−0.66; −0.03) T26 −0.04 (−0.41; 0.32) 4.02 (−1.19; 9.23) 3.20 (0.62; 5.78) 0.25 (−2.42; 2.93) 0.35 (−0.37; 1.08) 1.18 (−7.32; 9.67) −0.11 (−3.03; 2.81) 0.52 (−1.88; 2.93) 0.78 (−1.26; 2.82) −0.68 (−7.15; 5.78) −3.12 (−8.61; 2.38) −3.30 (−11.10; 4.49) −0.47 (−5.76; 4.82) −11.60 (−28.44; 5.25) 0.02 (−16.75; 16.79) −5.89 (−13.99; 2.22) −0.52 (−6.54; 5.50) −0.12 (−0.50; 0.27) 0.85 (−0.17; 1.86) −0.00 (−1.34; 1.34) −0.15 (−1.50; 1.20) 0.28 (−0.42; 0.98) 0.48 (−3.51; 4.47) 0.02 (−0.18; 0.22) −0.04 (−0.29; 0.21) 0.03 (−0.21; 0.26) −0.02 (−0.20; 0.17) −0.04 (−0.36; 0.27) T52 CBT: cognitive behavioral therapy; MS: multiple sclerosis; CIS20r: Checklist Individual Strength; IPA: Impact on Participation and Autonomy; FSS: Fatigue Severity Scale; MFIS: Modified Fatigue Impact Scale; SF: Short Form; RAP: Rehabilitation Activity Profile; β: beta for between-group effect, that is, the between-group difference at that time point. aLower is better; significant between-group differences are presented in bold. Primary outcomes CIS20r_fatigue (8-56)a IPA indoors (0-4)a IPA family role (0-4)a IPA outdoors (0-4)a IPA social relations (0-4)a IPA work and education (0-4)a Secondary outcomes FSS (1-7)a MFIS total (0-84)a MFIS physical (0-36)a MFIS cognitive (0-40)a MFIS psychosocial (0-8)a CIS20r total (20-140)a CIS20r concentration (5-35)a CIS20r motivation (4-28)a CIS20r physical activity (3-21)a SF36 vitality (0-100) SF36 physical functioning (0-100) SF36 bodily pain (0-100) SF36 general health (0-100) SF36 physical role functioning (0-100) SF36 emotional role functioning (0-100) SF36 social functioning (0-100) SF36 mental health (0-100) RAP communication (0-4)a RAP mobility (0-15)a RAP self-care (0-10)a RAP occupation (0-14)a RAP relationships (0-9)a Overall Mixed linear model; β (95% confidence interval) Between-group effect Table 3. Between-group effect of CBT versus MS nurse consultations, corrected for baseline value and center. Multiple Sclerosis Journal 23(11) journals.sagepub.com/home/msjhttps://journals.sagepub.com/home/msj