Multiple Sclerosis Journal 23(11) Table 1. Demographics and baseline characteristics. Characteristics Gender (%F) Age (years) BMI (kg/m2) EDSSa Disease duration (years)a Type of MS (n) RRMS SPMS PPMS Use of MS medication (n) Interferon Glatiramer Natalizumab Fingolimod Tecfidera Laquinimod 4-aminopyridine CIRSa MMSE (0-30) Primary outcomes CIS20r fatigue (8-56)a IPA autonomy indoors (0-4)a IPA family role (0-4)a IPA autonomy outdoors (0-4)a IPA social relations (0-4)a IPA work/education (0-4)a Secondary fatigue outcomes FSS (1-7)a MFIS total score(0-84)a MFIS physical (0-36)a MFIS cognitive (0-40)a MFIS psychosocial (0-8)a CIS20r concentration (5-35)a CIS20r motivation (4-28)a CIS20r physical activity (3-21)a Fitness parameters VO2peak (L/min) VO2peak (mL/kg/min) VO2peak (%predicted) Anaerobic threshold (%VO2peak)b Peak power (W) Total (N = 89) AT (n = 43) MS nurse (n = 46) 73.3 45.8 ± 9.7 25.5 ± 4.8 3.0 (2.0-3.6) 8.0 (2.0-15.3) 74.4 43.1 ± 9.8 25.6 ± 5.4 2.5 (2.0-3.5) 7.0 (2.0-10.0) 71.7 48.2 ± 9.2* 25.4 ± 4.3 3.0 (2.0-4.0)* 12.0 (2.0-19.0)* 65 8 16 31 3 9 34 5 7 21 11 7 4 1 1 2 1.6 (1.5) 28.7 (1.5) 9 5 3 3 - - 1 1.5 (1.5) 28.8 (1.4) 12 6 4 1 1 1 1 1.7 (1.5) 28.5 (1.6) 42.6 (8.0) 0.7 (0.6) 1.5 (0.7) 1.6 (0.8) 0.9 (0.5) 1.9 (0.9) 42.6 (7.4) 0.7 (0.6) 1.4 (0.7) 1.5 (0.7) 0.9 (0.5) 1.7 (0.9) 42.4 (8.5) 0.7 (0.6) 1.6 (0.7) 1.6 (0.8) 0.9 (0.5) 2.1 (0.8)* 5.3 (0.9) 41.2 (12.1) 20.2 (5.6) 17.4 (7.7) 3.7 (1.8) 19.8 (7.5) 14.9 (5.3) 12.4 (4.8) 5.2 (1.0) 40.8 (12.1) 19.7 (4.9) 17.7 (7.1) 3.5 (1.7) 20.9 (6.6) 15.1 (5.2) 12.1 (4.6) 5.3 (0.9) 41.5 (12.3) 20.6 (6.2) 16.8 (8.1) 3.9 (1.8) 18.7 (8.2) 14.7 (5.5) 12.8 (4.9) 1.64 (0.54) 21.6 (5.9) 64.4 (17.6) 43.9 (14.0) 151 (51) 1.75 (0.57) 22.6 (6.2) 65.0 (17.3) 45.0 (16.5) 161 (52) 1.53 (0.50) 20.8 (5.6) 63.7 (18.3) 42.9 (11.4) 142 (49) AT: aerobic training; MS: multiple sclerosis; BMI: body mass index; EDSS: Expanded Disability Status Scale; RRMS: relapsingremitting multiple sclerosis; SPMS: secondary-progressive multiple sclerosis; PPMS: primary-progressive multiple sclerosis; CIRS: Cumulative Illness Rating Scale; MMSE: mini-mental state exam; CIS20r: Checklist Individual Strength; IPA: Impact on Participation and Autonomy questionnaire; FSS: Fatigue Severity Scale; MFIS: Modified Fatigue Impact Scale; VO2peak: peak oxygen uptake; SD: standard deviation. All values are mean ± SD except for the EDSS and disease duration which are median (interquartile range). aLower score represents a better outcome. bThe anaerobic threshold is presented relative to the predicted peak oxygen uptake. *Significant (p < 0.05) between-group difference at baseline. 1522 journals.sagepub.com/home/msjhttps://journals.sagepub.com/home/msj