Tumori Journal Abstract Book - October 2020 - 91

D - COVID-19	
2020. We divided the visits into 3 groups: the first group
includes visits scheduled only in March, the second in
April (> 90%) and the third in May (> 90%).
Results At the first scheduled visit during the lockdown, 1
patient did not come, in 2 cases the caregiver came, 3
patients have postponed the visit, 10 were managed by
phone, 53 by phone and e-mail, 46 came to visit. In the
first and third phase, patients received the drug or prescription mainly directly in the clinic (40.17% and 47.94%
respectively), in contrast, in the second phase, shipping by
courier was preferred (37.5%). We noticed a correlation
between the basal ECOG performance status (PS), assessed
before the pandemic spread, and the modality of the visit
(p< .001). Most patients (55.75%) with PS ECOG 0 carried out the first visit in the lockdown phase electronically
(e-mail and telephone contact). However, no statistically
significant correlation emerged between the Charlson
comorbidity index and the method of carrying out the visit
(p 0.998). Comparing the baseline PS and that recorded at
the last visit, a statistically significant deterioration
emerged (p < .001). Considering the baseline ECOG PS 0,
at the third visit 52.94% of the evaluable patients maintained the PS. In 18 patients the data is missing.
Conclusions: Telemedicine seems to be feasible in some
contexts. The challenge is to select the right patient in the
right moment. PS could be a screening tool but other factors should be investigated such as availability of appropriate technology for telemedicine.

D49
PRACTICAL APPROACH TO THE
MANAGEMENT OF CLINICAL STUDIES
DURING THE COVID-19 EMERGENCY IN A
LARGE ACADEMIC HOSPITAL
Cicognini D.1, Zuccarini A.1, Ciani S.1, Pasi F.1, Sovico S.V.1,
Sciancalepore R.1, Pacciolla P.1, Arcaini L.1, Bruno R.1, Pedrazzoli P.1,
Ferrari A2.
IRCCS Policlinico San Matteo, Pavia; 2IRCCS Fondazione Policlinico San
Matteo, Pavia

91
the fast track procedure. For all these studies, Sponsor
companies and regulatory agencies requested the insertion
of data, as the progress of the patients, was monitored in
real time to assess their effectiveness, but also any potential damage through the communication of SAE.
Results: Since February 21st, 2 studies have not been activated at our Institution while 4 were activated through a
remote SIV. The screening of new patients was reduced and
in 2 studies it was temporarily suspended. Remote monitoring visits were carried out. At the same time the CTO-OH
supported the Infectious disease dept. and the whole hospital in conducting clinical studies for COVID-19 pts. Within
a month and half about 100 pts were enrolled, monitored;
data were collected and entered. A major problem was the
management of COVID patients enrolled in the various
operative units used for infected patients in which patients
were hospitalized or moved following the worsening/
improvement of their conditions. We were able to ensure
that the staff involved was correctly towed and updated.
Conclusions: The preparation and experience of the
CTO-OH team and the motivation of all the hospital staff
involved (physicians, nurses and lab personnel) allowed
the success of the COVID-19 studies while almost fully
preserving the ordinary Oncology-Hematology activity.

D50
SARS-CoV-2 infection in prostate
cancer patients: data from a highincidence area of North-Western
Tuscany
Bloise F.1, Sbrana A.1, Paolieri F.1, Manacorda S.1, Bazzurri S.1,
Nuzzo A.1, Sammarco E.1, Mercinelli C.1, Manfredi F.1, Gadducci G.1,
Giannini N.1, Paiar F.1, Pasqualetti F.2, Antonuzzo A.2, Falcone A.1,
Galli L.1
1

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina
e Chirurgia, Università di Pisa, Pisa; 2Azienda Ospedaliero-Universitaria
Pisana, Pisa

1

Background: The Fondazione IRCCS Policlinico San
Matteo, the largest academic Hospital in the south-west
part of Lombardy has been involved in the management of
the COVID-19 outbreak since its inception. The emergency required a deep reorganization of our Oncology/
Hematology Clinical trial office (CTO-OH) in order to
avoid significant disruption to usual practice, while facilitating clinical trials of the Infectous Disease Unit.
Materials and Methods: The activity of the CTO-OH
included 141 profit and no profit clinical studies before the
COVID outbreak. In addition to conducting already active
clinical studies, several clinical trials with active drugs and
procedure towards Covid-19 have been activated through

Background: Novel SARS-CoV-2 infection has been a
severe health problem in Italy since the beginning of
March 2020, with around 227,000 confirmed cases on
May 18th, 2020. The north-western part of Tuscany has
been one of the areas with the highest incidence
(342/100,000 inhabitants) and the highest lethality rate
(31.2/100,000 inhabitants). People aged 70-79 represented
half of this population and the deaths in this subgroup represented 15.9% of all SARS-CoV-2-related deaths. Cancer
patients are known to be at higher risk of incidence and
complications from SARS-CoV-2. We aimed at analyzing
the incidence and the lethality of SARS-CoV-2 in our prostate cancer (PC) patients (pts), in whom hormonal therapy
seems to be protective from the first evidences published
in the literature.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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