Tumori Journal Abstract Book - October 2020 - 77

D - COVID-19	
Ballatore Z.1, Bastianelli L.1, Merloni F.1, Ranallo N.1, Cantini L.1,
Catani C.1, Mariotti L.1, Lucarelli A.1, Burattini M.1, Berardi R.1
1
Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università
Politecnica delle Marche, Ancona, AOU Ospedali Riuniti-Ancona - Ancona, Ancona

77
Sartore-Bianchi A.1, Patelli G.1, Tosi F.1, Campisi D.2, Di Ruscio F.2,
Bencardino K.3, Amatu A.3, Bonazzina E.3, Cerea G.3, Carlo Stella G.3,
Giannetta L.3, Tartaglione L.2, Cassingena A.3, Agostara A.1, Vaghi C.1,
Pedrani M.1, Nichelatti M.3, Alteri C.2, Perno C.F.2, Siena S.1
1

Background: After COVID-19 was declared a pandemic
by the World Health Organization, a response from the
Italian Health System to react to an unprecedented condition became necessary and sudden. COVID-19 pandemic
required oncologists to redefine clinical organization and
management of cancer patients. The aim of our study was
to take a picture of the situation of Italian oncologies and
to evaluate the difficulties in patients management.
Methods: Between 18th March and 9th April 2020 we conducted an online survey (Google Forms). It consisted of 45
questions ranging from individual perception of pandemic
management by oncological centers to physicians and nurses
psychological distress and patient care. The survey was
anonymous and broadcasted to oncology health workers by
mailing contacts, word of mouth and social networks.
Results: A total of 383 oncology health workers participated
in the survey. The majority was female (72%) and from central Italy (46%). Impressively, a total of 357 (93%) participants declared the Oncologic Department reorganized
routine clinical activity, but only 41% was adequately trained
about the required procedures. 20% of the survey attendees
think they have not received adequate and timely protective
devices with respect to clinical needs and according to 58%
the supply of these devices was only partial. 34% of professionals declared they do not have or know a defined common
guideline to reschedule patients' treatments. More than 80%
of interviewees declared to feel worry about being at greater
risk of contagion than the general population, 92% feared to
transmit virus to family members. Deferring treatments has
caused fear / anxiety in 228 of the interviewed (60%).
Symptoms of stressful situations emerged with a deterioration in sleep quality in 62% of professionals, worsening of
mood (69%) and lower concentration ability (49%).
Conclusions: Our survey demonstrated the flexibility of
oncologic teams. However, the emergency response quality
has been heterogeneous, and several drawbacks emerged
from this first analyses. Information, protection, testing and
training of healthcare professionals are keywords that should
be kept in mind to encourage recovery after this tragedy and
to be ready to face a similar emergency in the next future.

D24
Incidence of SARS-CoV-2 infection
in patients with active cancer:
mono-institutional series of a
comprehensive cancer institution
in Lombardy during the COVID-19
pandemic (Niguarda Cancer
Center, Milano, Italy)

Dipartimento di Oncologia ed Emato-Oncologia, Università degli Studi di
Milano (La Statale), Milano, Milano; 2Analisi Chimico Cliniche e Microbiologia,
Grande Ospedale Metropolitano Niguarda, Milano, Italy, Milano; 3Niguarda
Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Milano

Background: Lombardy region, Italy, has one of world's
largest coronavirus disease 19 (COVID-19) outbreak with
over 80,000 cases. Here, we report the incidence of
SARS-CoV-2 infection in patients with active cancer at
the Division of Oncology, Niguarda Cancer Center,
Grande Ospedale Metropolitano Niguarda, a comprehensive cancer institution in the capital of Lombardy, Milano.
Patients and Methods: From April 15th to May 15th,
2020, SARS-CoV-2 testing has been performed in
patients with active cancer by paired real time-PCR in
nasopharyngeal swab (NPS) (Elitech, Torino, IT) and
chemiluminescent immunoassays for detection of antiviral IgG in blood (Abbot, Sligo, IR or Diasorin, Saluggia,
IT). Active cancer was defined as a solid tumor requiring
anticancer treatment or supportive care. Tested patients
were either outpatients with at least one suggestive
symptom of COVID-19 assessed by telephone triage per
local guidelines, or inpatients routinely tested at hospital
admission, irrespective of symptoms. Additionally,
patients with COVID-19 requiring hospitalization at
Niguarda Hospital during the study period have been
tested and results pooled for evaluating concordance of
NPS with serology.
Results: 118 patients were tested by NSP, and paired
serology is available at the moment for 63 (53.4%). In
the outpatient setting, 517 underwent telephone triage
and 58 reported at least one symptom (11.2%). Of these,
3/29 and 3/14 (10.3 and 21.4%) tested positive on NSP
and serology, respectively. In the cohort of inpatients,
tested regardless of symptoms, 2/82 and 4/42 (2.4 and
9.5%) tested positive on NSP and serology, respectively.
Finally, among oncology physicians, 2/34 and 2/34
(5.9%) tested positive on NSP and serology, respectively. 7 additional hospitalized patients displaying
COVID-19 disease have been tested. Overall, the accuracy between NSP and serology was 82.5% and concordance was 0.415 (Cohen's k). In 5 cases, serology was
positive and NSP negative, whereas the opposite was
found in 6. Recruitment and testing are still ongoing at
the moment of abstract submission and complete results
will be presented.
Conclusions: In our series of patients with active cancer
during a peak period of the pandemic in Lombardy, 11% of
outpatients displayed COVID-19 associated symptoms
and 10% had positive NSP. Among inpatients tested
regardless of symptoms, 2.4% had positive NSP. The accuracy between NSP and serology was 82.5%.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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