Tumori Journal Abstract Book - October 2020 - 73

D - COVID-19	

73

tract (12%), 39 melanoma and skin (9%), 31 gynecologic
(6%), 26 lung cancer (6%), 16 GEP (3%), 15 head and
neck (3%), and 18 other tumors (4%). Ten patients with
signs/symptoms of tumor recurrence were detected at
TFU: 1 had clinical symptoms, 3 abnormal blood tests and
6 suspicious radiological findings. These patients were
called for live visit and tumor relapse/progression was
confirmed in 10 out of 10 cases. Medical or surgical treatment was started, or planned to start, in all 10 patients.
Conclusions: TFU proved to be feasible with an eligibility
rate of 85% and 100% patients' compliance. The detection
rate for tumor recurrence was 2.1%.

cancer pts. The present score is currently undergoing
validation on a wide population of cancer pts, to confirm its role and potentially help physicians' treatment
decisions.

D16

Age

Developing a risk assessment
score for cancer patients during
COVID-19 pandemic

BMI

Indini A.1, Cattaneo M.2, Rijavec E.1, Ghidini M.1, Bareggi C.1, Galassi
B.1, Gambini D.1, Grossi F.1
1

Unità di Oncologia Medica, Fondazione IRCCS Ca' Granda Ospedale
Maggiore Policlinico, Milano, Milano; 2Dipartimento di Medicina (DAME),
Università di Udine, Udine

Background: Data on the novel coronavirus (CoV) respiratory disease (COVID19) in cancer patients (pts) are
limited. In some individuals, CoV infection triggers an
aberrant immune response, leading to lung tissue damage.
Cancer pts treated with immunotherapy (IT) may be more
at risk for COVID19 and its complication.
Methods: We performed a thorough review of the literature on CoV pathogenesis and cancer. We selected shared
features of the two disease entities to develop a riskassessment score quantifying both the risk of infection and
that implied in cancer treatment delay.
Results: The score includes clinical and laboratory variables
(Table 1). Pts' characteristics include: age, comorbidities
(hypertension, cardiovascular disease, diabetes, chronic
obstructive pulmonary disease, chronic systemic infections),
obesity, sex, Eastern Cooperative Oncology Group (ECOG)
performance status (PS), and concomitant steroid treatment
(>10 mg/day of prednisone equivalent, lasting for >1month period). Disease characteristics include: lung cancer
diagnosis, history of thoracic radiotherapy (RT) (only for pts
with extra-thoracic tumor). Treatment characteristics include:
line of treatment, type (IT or combined IT/chemotherapy
[CT] considered high-risk, followed by CT, and other anticancer drugs), history of immune-related adverse events
(irAEs). Laboratory tests include levels of neutrophil-tolymphocite ratio (NLR), lactate-dehydrogenase (LDH), and
C-reactive protein (CRP). Based on the resulting score, pts
are divided in the following risk categories: low (score <4),
intermediate (score 4-6), and high risk (score >7).
Conclusions: There is a strong rationale supporting
these variables as potential risk factors for COVID19 in

Table 1.  The "Milano Policlinico ONCOVID Score" for risk
evaluation during COVID19.
Variables

Score

Sex

F=0
M=1
0-1 = 0
2, or higher = 1
<70 = 0
70, or higher = 1
<30 = 0
30, or higher = 1
NO = 0
YES = 1
YES > 1 = 2
NO = 0
YES = 1
NO = 0
YES = 1
NO = 0
YES = 1
(neo)adjuvant = 0
1, or more = 1
Hormone therapy/targeted
therapy/monocolonal
antibodies = 0
CT = 1
IT/IT + CT = 2
NO = 0
YES = 1
YES, pneumonitis = 2
<5 = 0
5, or higher = 1



Tumori Journal Abstract Book - October 2020

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Tumori Journal Abstract Book - October 2020 - I
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Tumori Journal Abstract Book - October 2020 - Cover3
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