Tumori Journal Abstract Book - October 2020 - 65

D - COVID-19	
Background: The prospective, multicenter, observational
INVIDIa-2 study was designed to investigate the clinical
efficacy of influenza vaccination in advanced cancer
patients receiving immune checkpoint inhibitors (ICIs)
from October 2019 to January 2020. The primary endpoint was the incidence of influenza-like illness (ILI)
until April 30, 2020. All ILI episodes, laboratory tests,
complications, hospitalizations and pneumonitis were
recorded. Therefore, the INVIDIa-2 study prospectively
recorded all the COVID-19 ILI events.
Methods: Patients were included in this non-prespecified
COVID-19 preliminary analysis if potentially exposed to
Sars-Cov-2 infection, namely alive on January 31, 2020,
when the Italian government declared the National emergency. The incidence of confirmed COVID-19 was
assessed among patients with ILI symptoms, describing
the hospitalization rate and mortality. Cases with clinicalradiological diagnosis of COVID-19 without laboratory
confirmation (COVID-like ILIs), were also reported. The
COVID-incidence was exploratively compared basing on
influenza vaccination.
Results: 1260 patients receiving ICI were enrolled between
October 2019 and January 2020; 955 patients were analyzed
according to the inclusion criterion. Of them, 66 patients had
ILI from January 31, to April 30, 2020. 9 were COVID-19
ILIs with laboratory test confirmation. The COVID-19 ILI
incidence was 0.9% (9/955 cases), with hospitalization rate
of 100% and mortality rate of 67%. Including 5 COVID-like
ILIs, the overall COVID-19 incidence was 1.5% (14/955),
with hospitalization in 100% of cases and mortality rate of
64%. COVID-19 incidence was 1.2% for patients vaccinated
against influenza (6/482 cases) and 1.7%, among unvaccinated patients (8/473 including 3 confirmed COVID-19 and
5 COVID-like), p = 0.52. The difference was not statistically significant, and the clinical trend in favor of vaccinated
patients was lost when considering only confirmed COVID19 (1.2% in vaccinated vs 0.6% in unvaccinated patients, p
= 0.33), probably due to the greater presence of male and
elderly patients in the vaccinated group (p = 0.009).
Conclusions: We obtained the first prospective epidemiological data about symptomatic COVID-19 in advanced
cancer patients receiving ICIs. The overall symptomatic
COVID-incidence is meaningful, requiring hospitalization
in all cases and leading to a high mortality rate, likely due
advanced cancer more than to ICI therapy [Mengyuan Dai,
Cancer Discov 2020].

D02*
The beginning of the Covid-19 era.
The perception of oncological
patients (pts) in active treatment
at the Brindisi and Mauriziano
Hospital Oncology Departments

65
Loparco D.1, Di Maio M.2, Orlando L.3, Dascanio F.2, Caliolo C.3,
Ignazzi G.2, Schiavone P.3, Lacidogna G.2, Quaranta A.3, Marino D.2,
Del Bene G.3, Vignani F.2, Fedele P.3, Sperti E.2, Caloro M.3, Terzolo
S.2, Fusco L.2, Ballaminut D.2, D'Amico M.3, Cinieri S.3
1

UOC Oncologia Medica - P.O. Perrino ASL Brindisi, Bindisi; 2Azienda
Ospedaliera Ordine Mauriziano di Torino, Torino; 3UOC Oncologia Medica P.O. Perrino - ASL Brindisi, Brindisi

Background: The exceptional circumstances caused by
the Covid-19 pandemic have had a strong logistical and
psychological impact on the population. A specific attention has been devoted to the organization of activity of
Oncology units and to oncological patients' mental health
conditions. In fact, together with the anxiety caused by the
disease, oncological pts are now experiencing also apprehension because of the pandemic. The aim of this research
is to evaluate how the Covid-19 emergency has affected
access to treatments, management of disease and the psychological impact on pts in 2 Oncology Units in Brindisi
(Apulia) and Turin (Piedmont).
Methods: In a 2 week period between April and May
2020, a structured questionnaire was administered to pts in
active treatment at the Day hospital (DH)/ Day Service
(DS) of Oncology Dpts at Brindisi and Mauriziano
Hospital. The questionnaire was anonymous, self-administered, with 5 closed-ended questions with a "yes/no"
answers and 10 questions involving a modified Likert
scale of 4 answers (not at all, a little, quite a bit, very
much). Percentage data are analyzed for the whole series
and the 2 centers separately.
Results: 404 questionnaires were collected (Brindisi 202,
Turin 202). The main difference involves the number of
pts with relatives tested positive to SARS-CoV2 (Apulia
2% vs Piedmont 11.4%, p=0.002). Overall, 343 pts
(84,9%) referred no relevant changes in the treatment of
their illness. They indicated no relevant alterations in the
access to medical care (n= 362, 90%), in outpatient visits
(n= 341, 84.8%), in running diagnostic exams (n= 340,
84.6%) and in drug supply (n= 365, 90.8%). 291 pts
(72,4%) did not perceive a significant risk of contagion in
accessing their DH/DS. Overall, pts did not believe they
have received a significant reduction in assistance (n=372,
92.1%). The communication with the medical staff has
been judged effective and clear (n= 374, 93%) and pts
claimed it had been easy to reach the staff via phone and/
or e-mail (n=364, 90.1%). There were no relevant differences between the 2 centers.
Conclusions: Despite the changes in the clinical management of cancer pts due to the Covid-19 emergency,
our data show that most pts did not perceive any relevant
difference in the management, both from an operational
and relational point of view. In perspective, we aim to
promote a comparative analysis between the 2 regions,
to take into account the different morbidity of the Covid19 infection.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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