Tumori Journal Abstract Book - October 2020 - 64

64	
OS were comparable between the NabP-GEM and FOL
groups: PFS was 15.0 vs 14.3 months; p=0.50. OS was 22.8
vs 22.6 months; p=0.86. There was no difference in the percentage of toxicity G3/G4 event between the two groups
(p=0.723). Sex, radiotherapy and treatment duration
resulted significant factor related to PFS in the multivariate
model (p-value=0.02, <0.001, <0.001 respectively); radiotherapy, treatment duration and subsequent line of therapy
resulted related to OS (p-value 0.008, <0.001, <0.001
respectively). 69 (56.10%) patients performed subsequent
second-line chemotherapy after progression of first-line, 39
(53.43%) of the NabP-GEM group and 30 (60%) of FOL
group, with no significant difference.
Conclusions: The literature suggest first line FOL mainly
based on the patient conditions with worse toxicity profile
compared to NabP-GEM. Our study demonstrate no difference in the first line in outcome survival between the two
treatments; unexpectedly no greater FOL-related toxicity,
probably due to safe and effective FOL dose reduction in a
variable quote of patients. First treatment choice need to
consider the recent result of FOL in neoadjuvant and adjuvant settings, that can shift this regimen before the first line,
and the recent data about the PARP inhibitors in a subpopulation first-line platinum-based chemotherapy responders.

Tumori Journal 106(2S)
progression-free, and overall survival. Sensitivity, specificity, and possible correlations were analyzed.
Results: Sensitivity and specificity of the G8 score for
severe toxicity were respectively 55.9% (95% CI 39,45% to
71,12%) and 50% (95%CI 18,76% to 81,24%). No association between all types of severe grade 3-4 toxicity, delays, or
dose reductions, and the G8 score was present (p=0.622, not
significant). ORR was 32.5% (95% CI; 20.1-49.3) with no
complete responses. Twelve patients achieved stabilization
of disease (30%) for a TGCR of 62.5% (95% Cl; 47.7-76.3).
Median PFS and OS were 4.5 months and 8.1 months,
respectively. Correlation between G8 score and PFS was not
statistically significant (r -2944; p=0.0652). Correlation
between G8 score and OS was statistically significant (r
-0.3539; p=0.0251). Although median survival of G8 fit
patients was superior to that of G8 vulnerable patients (6.5
months versus 4 months, respectively) the difference was
not statistically different (p=0.1975)
Conclusions: Clinical results in terms of response rate,
survival outcomes, and side-effects were in the range
reported by others. However, the G8 questionnaire is not a
reliable diagnostic tool to predict the risk of severe toxicity, rate of chemotherapy completion, and clinical outcomes in elderly patients with aPAC cancer treated with
the nab-paclitaxel and gemcitabine. Future prospective
studies should investigate the role of other questionnaires.

C35
Management of older patients
with advanced pancreatic cancer:
the G8 geriatric assessment tool
does not seem to be a reliable tool
to detect frailty
Gebbia V.1, Mare M.2, Cordio S.3, Valerio M.R.4, Piazza D.5,
Bordonaro R.6, Firenze A.7, Giuffrida D.2
1
Medical Oncology Unit, Casa di Cura La Maddalena, Palermo; 2Medical
Oncology Unit, Istituto Oncologico del Mediterraneo, Viagrande (CT);
3
Medical Oncology Unit, Ospedale "Paternò Arezzo", Ragusa; 4Medical
Oncology Unit, Policlinico "Paolo Giaccone", University of Palermo, Palermo;
5
GSTU Foundation for Cancer Research, Palermo; 6Medical Oncology Unit,
ARNAS Garibaldi, Catania; 7Risk Management Unit, Policlinico "Paolo
Giaccone", University of Palermo, Palermo

Background: This paper aims to analyze the usefulness of
the G8 geriatric oncology questionnaire in patients with
advanced/metastatic pancreatic adenocarcinoma (aPAC) and
its possible association with different clinical outcomes.
Material and Methods: Patients age > 70 years with
aPAC were screened with the G8 tool. Patients were treated
at four medical oncology units with a regimen of intravenous nab-paclitaxel 125 mg/m2 and gemcitabine 1000 mg/
m2 for 3 consecutive weeks followed by one-week rest as
prescribed after clinical evaluation by treating oncologists.
Patients charts were evaluated for type and severity of toxicity, 2 cycle rate of completion, discontinuation rate,
delays, dose reductions, and other outcomes response rates,

D - COVID-19
D01*
COVID-19 analysis from the
multicenter, prospective,
observational INVIDIa-2 study
(INfluenza Vaccine Indication During
therapy with Immune checkpoint
inhibitors: a transversal challenge)
- a FICOG study
Buti S.1, Giannarelli D.2, De Giorgi U.3, Pignata S.4, Di Maio M.5,
Clemente A.6, Verzoni E.7, Guadalupi V.7, Giusti R.8, Garassino
M.7, Taurelli Salimbeni B.8, Veccia A.9, Mazzoni F.10, Aprile G.11,
Baldessari C.12, Cortellini A.13, Verderame F.14, Montesarchio V.15,
Rizzo M.16, Procopio G.7, Bersanelli M.1
1

Azienda Ospedaliero-Universitaria di Parma, Parma; 2Istituto Nazionale
Tumori Regina Elena, Roma; 3IRCCS Istituto Scientifico Romagnolo per lo
Studio e la Cura dei Tumori, Meldola; 4IRCCS Istituto Nazionale Tumori G.
Pascale, Napoli; 5Ospedale Mauriziano - Università degli Studi di Torino,
Torino; 6IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei
Tumori, Ravenna; 7IRCCS Istituto Nazionale Tumori di Milano, Milano;
8
Azienda Ospedaliero Universitaria Sant'Andrea, Sapienza Università di
Roma, Roma; 9Ospedale Santa Chiara, Trento; 10Azienda Ospadaliero
Universitaria Careggi, Firenze; 11Ospedale San Bortolo Azienda ULSS8
Berica - Distretto Est, Vicenza; 12Policlinico di Modena, Centro Oncologico
Modenese, Modena; 13Ospedale San Salvatore, Università dell'Aquila,
L'Aquila; 14Azienda Ospedali Riuniti Villa Sofia Cervello, Palermo; 15Azienda
Ospedaliera Specialistica dei Colli - Monaldi, Napoli; 16Istituti Clinici
Scientifici Maugeri, Pavia



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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