Tumori Journal Abstract Book - October 2020 - 63

C - Gastrointestinal (non-Colorectal) Cancers	

63

Massucci M.1, Andrini E.1, Bonucci C.1, Ricci A.D.1, Rizzo A.1, Tober
N.1, Rojas Llimpe F.L.1, Di Fabio F.1, Ardizzoni A.1
1

Sant'Orsola-Malpighi Hospital, Bologna

Background: In locally advanced resectable gastric or
gastroesophageal junction adenocarcinoma perioperative
chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin
and docetaxel (FLOT) improves overall survival compared to perioperative epirubucin, cisplatin and 5-fluorouracil/capecitabine (ECF/ECX).
Material and methods: In this observational-retrospective study we analyzed patients (pts) with locally advanced
gastric cancer who received perioperative chemotherapy
(FLOT) between December 2017 and January 2020. Our
intent was to explore the compliance, safety and effectiveness of FLOT in this setting.
Results: A total of 17 pts were screened to receive perioperative chemotherapy with FLOT. Median age was 68yrs.
Performance Status (PS) was 0 in 6 pts (35,3%), 1 in 9 pts
(52,9%) and 2 in 1 pt (5,9%). 13 pts (76,5%) were staged by
CT scan and FDG-PET, 4 pts (23,5%) with CT scan alone
and only 1 pt (5,9%) underwent diagnostic laparoscopy
before starting treatment. Clinical stage was I for 1 pt
(5,9%), II for 5 pts (29,4%), III for 10 pts (58,8%) and IV for
1 pt (5,9%). After staging, 16 pts were considered eligible to
receive FLOT and the final analysis was performed on these
pts. 13 pts (81,2%) completed preoperative phase with 4
cycles of FLOT and, among 13 pts (81,2%) who underwent
surgery, 6 pts (46%) received postoperative chemotherapy
with FLOT. 2 pts (12,5%) died after the first preoperative
cycle of FLOT (one of them had poor PS), 3 pts (18,7%)
were found to be metastatic during surgery and 1 pt (6,2%)
relapsed in a short time. High-grade adverse events occurred
in 5 pts. Pathological complete response (pCR) has been
obtained only in 1 pt. At a median follow up of 13,6 months
(95% C.I. 6,2-21), median OS and RFS were not reached.
Only 1 of the pts who completed treatment relapsed.
Conclusions: From this study stands out the importance of
a correct clinical selection and thorough staging of pts.
Indeed, in our experience, perioperative chemotherapy with
FLOT is well tolerated and effective in well selected pts.
CHARACTERISTICS

PTS (n=17)

SEX
male
female
PS
0
1
2
STAGING
I
II

 
13 (76,5%)
4 (23,5%)
 
6 (35,3%)
9 (52,9%)
1 (5,9%)
 
1 (5,9%)
5 (29,4%)
(Continued)

CHARACTERISTICS

PTS (n=17)

III
IV
IMAGING
ct
ct+ fdg-pet
ct+laparoscopy
COMPLIANCE
completed preoperative phase
full doses
completed postoperative phase
full doses
PROPHYLAXIS G-CSF
primary
secondary
PATHOLOGICAL RESPONSE
pCR
ADVERSE EVENT
gi G3/G4
hematological G3/G4
stomatitis G3/G4
asthenia G3/G4

10 (58,8%)
1 (5,9%)
 
4 (23,5%)
13 (76,5%)
1 (5,9%)
 
13 (81,2%)
10 (62,5%)
6 (37,5%)
2 (12,5%)
 
12 (70,6%)
1 (6,2%)
 
1 (6,2%)
 
1 (6,2%)
2 (12,5%)
1 (6,2%)
1 (6,2%)

C34
FOLFIRINOX versus gemcitabine
plus nab-paclitaxel as first
line treatment in patients with
advanced/metastatic pancreatic
cancer: a retrospective study
Orlandi E.1, Citterio C.1, Stroppa E.1, Vecchia S.1, Cavanna L.1
1

ospedale Guglielmo da Saliceto, Piacenza

Background: Advanced pancreatic cancer show a poor
prognosis. Fortunately, the treatment of patients with
advanced unresectable or metastatic disease is challenging.
Current guidelines recommend Nab-Paclitaxel plus
Gemcitabine (NabP-GEM) or FOLFIRINOX (FOL) as
first-line treatment, thereby leaving the choice up to the
treating physician. Data on comparison of efficacy and toxicity of FOL and NabP-GEM in metastatic cancer are fragmentary and poor.
Material (patients) and methods: A total of 123 patients
with histologically confirmed diagnosis of advanced or metastatic pancreatic cancer received either first-line therapy
(NabP-GEM or FOL) between March 2013 and January
2019 at the Piacenza Hospital. We evaluated retrospectively
prognostic factors for PFS and OS; variables which showed
potential association in the univariate analyses (p<0.05)
were further tested in the multivariate analyses.
Results: 50 (40.65%) patients received first line FOL (86%
received a dose reduction) and 73 (59.35%) received first
line NabP-GEM, with no significant difference in baseline
patient's and disease's characteristics. The median PFS and



Tumori Journal Abstract Book - October 2020

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