Tumori Journal Abstract Book - October 2020 - 61

C - Gastrointestinal (non-Colorectal) Cancers	

61

1

S.C. Oncologia - A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria;
A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria; 3Università Piemonte
Orientale. A. Avogrado, Alessandria; 4S.C. Oncologia - A.O. SS Antonio e Biagio
e Cesare Arrigo, Alessandria; 5Chirurgia Generale- Ospedale Santo Spirito
Casale Monferrato, Casale Monferrato; 6Gastroenterologia - A.O. SS Antonio e
Biagio e Cesare Arrigo, Alessandria; 7SC Radiologia - A.O. SS Antonio e Biagio
e Cesare Arrigo, Alessandria; 8SC Chirurgia Generale - A.O. SS Antonio e Biagio
e Cesare Arrigo, Alessandria; 9Medicina Generale-Ospedale Civile di Ovada,
Ovada; 10Anatomia Patologia- Ospedale Santo Spirito Casale Monferrato,
Casale Monferrato; 11Anatomia Patologia- A.O. SS Antonio e Biagio e Cesare
Arrigo, Alessandria; 12Anatomia Patologia- Ospedale Cardinal Massaia, Asti;
13
S.C. Medicina Nucleare- A.O. SS Antonio e Biagio e Cesare Arrigo, Alessandria
2

Background: The NLR is a simple and universally available index whose prognostic value has been shown in other
solid tumors. We aimed at assessing the role of NLR in a
series of pts with APC consecutively treated in our center.
Patients and methods: All the pts with APC undergoing
chemotherapy since October 2017 were consecutively
included in our data base. Baseline demographic and clinical
characteristics were recorded, together with chemotherapy
regimen, objective response rate, date of disease progression
and of last follow up or death. For the time-to-event analysis
median follow up of surviving pts was 11,2 months.
Results: 74 pts were included: 40 males (54,1%) and 34
females (45,9%); median age 69 (range 38-82). Site of primary: pancreatic head in 50 (67,6%), body in 10 (13,1%),
tail in 11 (14,9%). In two pts the tumor was originating
from the Vater papilla and in one case the primary could
not be detected. Baseline ECOG PS was 0 in 36 (48,6%),
1 in 35 (47,3%) and 2 in 3 pts (4,1%). Forty-six pts (62,2%)
complained for pain,18 (24,3%) for fatigue and 27 (36,5%)
for jaundice. CA19.9 was = upper normal limits (UNL- 37
ng/mL) in 52 (70,3%), LDH (UNL 500 U/L) in 8 (10,8%).
NLR = 3 was found in 26 pts (35,1%) and was >3 in 48
(64,9%).Pts were treated with either Gemcitabine (9,
12,2%), FOLFIRINOX (7, 9,5%) or Gemcitabine - Nabpaclitaxel (58, 78,4%). An objective response occurred in
12 pts (16,3%). Median PFS was 5,7 months (95% CI 2,7
- 8,7) and median OS was 7,9 months (95% CI 5,0-10,7).
At univariate analysis the impact of the NLR on PFS was
marginally significant while achieved the statistical significance for OS. Other factors that had a statistically significant impact on OS were PS, stage of disease, LDH
value and the occurrence of fatigue. At multivariate analysis performed using the Cox proportional hazards model
PS (0 vs 1-2) LDH (
3) were the only factors retaining statistical significance.
Conclusions: In pts with APC undergoing chemotherapy
the NLR could be an adjunctive tool in the prognostic
evaluation. Further and wider analyses should be conducted in order to validate the use of this laboratory tool in
clinical practice.

Median PFS (months)
Median OS (months)

NLR ⩽ 3

NLR>3

p

6,5
13,8

3,3
6,6

0.085
0.017

C30
Statins inhibit the growth of
hepatoma cells: finding the anticancer pathway using three
different human hepatoma
cell lines
Santini S.J.1, Settepanella I.2, Balsano C.1
1

MESVA Department, University of L'Aquila; Francesco Balsano
Foundation, L'Aquila; 2Università degli Studi di L'Aquila, L'Aquila
Background: Hepatocellular carcinoma (HCC) is the fifth
most common tumor in the world and the third cause of
cancer mortality. Systemic chemotherapy is not a suitable
option for most patients. Observational studies suggest a
modest, but significant, reduction in the risk of liver cancer
in patients with chronic liver disease who take statins.
Recent studies have shown that statins can have potential
protective effects against cancer, but only few and disagree
studies have examined the relationship between liver cancer and statins. More research is needed to clarify the
mechanism responsible for this effect. The aim of this
work is to evaluate both the effect of statins on HCC cell
lines, and to highlight the possible pathways involved.
Material and methods: We tested two of the most used
statins, atorvastatin and rosuvastatin (Rosu), on three different human hepatoma cell lines: Huh7, Hep3B, and HepG2.
Results: Rosuvastatin was more effective than atorvastatin.
Cell viability was reduced by Rosu in all cell lines, but the
reduction was significant only in HepG2 and HuH7. Rosu
induced cell cycle arrest in the G2/M phase in all the three
cell types, and it was more effective on HepG2. A significant
increase in apoptotic cells was observed only in Hep3B cells.
Conclusions: In conclusion, Rosu inhibits tumor growth
in all the hepatocarcinoma cell lines analyzed, but it is able
to induce apoptosis only in Hep3B. The main difference
among Huh7, Hep3B and HepG2 is related to different
level of p53 expression. HepG2 cells carry wild-type p53,
whereas Hep3B and Huh7 cells have null and point mutations at p53, respectively.
The reasons above support the idea that Rosu could cause
G2/M cycle arrest in a p53 independent way. In addition,
the absence of p53 in Hep3B, seems to make these cells
more sensitive to apoptosis after Rosu treatment.

C31
LDH levels as prognostic factor
in second line treatment for
advanced gastric cancer: the LINE
study
Michelotti A.1, Ongaro E.1, De Scordilli M.1, Gerratana L.1, Mazzeo
R.1, Di Nardo P.1, Foltran L.1, Guardascione M.1, Basile D.1, Cortiula
F.1, Miolo G.1, Fanotto V.1, Parnofiello A.1, Lisanti C.1, Bertoli E.1,
Buriolla S.1, Buonadonna A.1, Puglisi F.1



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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Tumori Journal Abstract Book - October 2020 - Cover3
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