Tumori Journal Abstract Book - October 2020 - 58

58	
of Trieste, Trieste; 4Division of Medical Oncology, Department of OncoHematology, IRCCS-CROB, Referral Cancer Center of Basilicata, Potenza;
5
Translational Oncology Unit, University Hospital Careggi, Firenze, Firenze;
6
Department of Medicine, Surgery and Neurosciences, Medical Oncology
Unit, University of Siena, Siena; 7Department of Biology and Biochemistry,
University of Bath, United Kingdom

Background: Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (Nab-Gem) therapy.
We retrospectively investigated the association between
neutropenia induced by first-line Nab-Gem and survival in
metastatic pancreatic carcinoma patients Nab-Gem.
Patients and methods: Metastatic pancreatic patients
treated with first-line Nab-Gem were included in this retrospective analysis. Neutropenia was categorized using
the National Cancer Institute Common Toxicity Criteria
toxicity scale. Outcome measures were overall survival
(OS), progression-free survival (PFS) and response rate.
Results: 115 patients were analyzed. Median PFS was 7
months (95% CI 5-8) in patients with grade =3 neutropenia
and 6 months (95% CI 5-6) for patients with grade <3
neutropenia (p=0.08; hazard ratio (HR: 0.68). Median OS
was 13 months (95% CI 10-18) in patients with grade =3
neutropenia and 10 months (95% CI 8-13) for patients
with grade < 3 neutropenia (p=0.04; HR: 0.44). In multivariate analysis, the occurrence of grade = 3 neutropenia
showed a statistically significant association with OS (HR:
0.62; 95% CI, 0.09-0.86; P=0.05).
Conclusions: Nab-Gem-induced neutropenia is associated
with longer survival in metastatic pancreatic cancer patients.

C24
Neutrophil/lymphocyte ratio and
its optimal cut-off is associated
with long survival in metastatic
PANCREATIC cancer patients
Mauro E.1, Carandina I.2, Tiberi E.2, Farina J.2, Fasano A.R.2,
Cecchetto C.2, Martella L.R.2, Lancia F.2, Toma I.2, Frassoldati A.2
1

Azienda Ospedaliera -Universitaria, Ferrara; 2Azienda Ospedaliero Universitaria, Ferrara

Background: Long survival is rare in pancreatic cancer,
and limited information are available about determinants
of favourable outcome. The NLR (neutrophils/lymphocytes ratio) has been reported as a prognostic factor in
early stage pancreatic adenocarcinoma, due its relation to
the dominant inflammatory or immune status of the
patient, but data are lacking in the metastatic disease.
Patients and methods: To evaluate the possible prognostic
role of NLR in stage IV pancreatic cancer, we retrospectively
analyzed patients treated at our institution (Oncology Unit of
Ferrara) between 2013 and 2019. We analyzed the prognostic effect on survival of clinical (like age, BMI, ECOG PS,
tumor site, location of metastases, obstructive jaundice, diabetes, previous therapies) and biological parameters (like

Tumori Journal 106(2S)
CEA and CA19.9 tumor markers, NLR, PLR (platelets/lymphocytes ratio) and LMR (lymphocytes/ monocytes ratio).
Published cut-off of these parameters, as well as optimal cutoff defined by ROC curves have been used to predict the
long survival.
Results: 106 patients with stage IV pancreatic cancer were
retrospectively collected. Median age was 65 years. ECOG
PS was > 0 in 62% of the patients. A better mOS has been
associated with baseline NLR, both using cut-off of ⩽ 4 (8
m vs 4 m, p=0,006), and a cut-off of ⩽ 2,5 (11 m vs 5 m di
mOS, p=0,024). At this cut-off level, baseline NLR showed
an independent prognostic value in multivariate analysis
(HR= 1,940, IC 95% 1,230-3,061, p=0,010). Moreover, we
evaluate the optimal cut-off by generating ROC curves for
NLR. The NLR cut-off of ⩽ 2,83, (AUC=0,648, p=0,022;
sensibility 90%, specificity 54.26%) showed the best performance. Baseline CEA ⩽5 resulted also a parameter associated with long survival (8 m vs 5 m, p= 0.005), with HR=
1,816, IC 95% 1,161-2,843, p=0,004 in multivariate analysis. The CEA optimal cut-off by ROC curves able to discriminate the long survivors was ⩽3,9 (AUC=0,714,
p=0,012, (sensibility 90%, specificity 52.58%). No significant results were observed for PLR, LMR, CA19.9, age, and
disease characteristics at onset of metastases.
Conclusions: Two factors resulted associated to a different
prognosis in terms of overall survival: NLR < 2,83 and
CEA<3.9 at baseline. These simple parameters might be
useful to estimate prognosis in advanced pancreatic cancer.

C25
Continuum of care for
unresectable hepatocarcinoma
(uHCC): a referral-centre
experience on sequential
strategies
Massa V.1, Pecora I.1, Salani F.1, Vivaldi C.1, Bargellini I.2, Crocetti L.2,
Fornaro L.1, Oliveri F.3, Cesario S.1, De Simone P.4, Romagnoli V.3,
Catalano G.4, Brunetto M.R.3, Catanese S.1, Caccese M.1, Bernardini
L.1, Vasile E.1, Lencioni M.1, Falcone A.1, Masi G.1
1
Oncologia Medica, Università di Pisa, Pisa; 2Radiologia Diagnostica ed
Interventistica, AOUP, Pisa; 3Epatologia, AOUP, Pisa; 4Chirurgia Epatica e del
Trapianto di fegato, AOUP, Pisa

Background: A wider accessibility to tyrosine-kinase
inhibitors (TKI), antiangiogenics and immuno-oncological (IO) drugs, have pushed the therapeutic paradigm for
uHCC toward sequential strategies. However, how to tailor them on patients (pts) is still unclear.
Methods: We retrospectively analysed data from uHCC
pts treated with ⩾2 lines at our Centre from January 2010.
We aimed to describe different sequences' efficacy in
terms of overall survival (OS) and progression-free survival (PFS) 1+2 -the time from first line beginning to progression of disease (PD) at second line.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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