Tumori Journal Abstract Book - October 2020 - 57

C - Gastrointestinal (non-Colorectal) Cancers	
groups, and statistically higher in LOGC (63.1% vs 51.7%
of EOGC, p 0.003). No difference in sex was observed
(male sex 56.1% in EOGC vs 58.8% in LOGC, p 0.76). OS
was significantly longer in EOGC compared with LOGC
(HR 0.54, 95%CI 0.42-0.70, p<0.001). This favorable
prognostic association was consistent across subgroups (sex
and histologic subtype). EOGC (HR 0.54, 95%CI 0.410.72) and intestinal subtype (HR 0.82, 95%CI 0.72-0.95)
retained a significant positive impact on OS on multivariate
analysis. However, the intestinal subtype did not show its
favorable prognostic association in EOGG (HR 0.99, p
0.96). Sex never correlated with OS, either in the whole
cohort (HR 0.90, p 0.15) or in EOGC (HR 0.84, p 0.35).
Conclusions: In contrast with reports from other parts of
the world, we observed a neat decline in incidence of
EOGC, apparently steeper than that observed with LOGC.
EOGC cases displayed a meaningfully better prognosis, as
well as a differential prognostic impact of histology subtype. Limitations of this study include the lack of distinction between gastric and cardias site and the irretrievability
of histology subtype for a conspicuous share of patients.

C22
Association of region of origin
with early-onset gastric or
gastroesophageal junction
cancer in a large city of
Northern Italy
Filippi R.1, Laface R.2, Patriarca S.3, Spadi R.2, Satolli M.A.2, Ponzetti
A.2, Cristiano C.2, Aglietta M.4, Ciuffreda L.2
1
S.C. Oncologia Medica 1 - AOU Città della Salute e della Scienza di Torino;
Candiolo Cancer Institute, FPO - IRCCS Candiolo, Moncalieri; 2S.C. Oncologia
Medica 1 - AOU Città della Salute e della Scienza di Torino, Turin; 3Piedmont
Cancer Registry - CPO Piemonte - AOU Città della Salute e della Scienza di
Torino, Turin; 4Candiolo Cancer Institute, FPO - IRCCS - Str. Prov. 142, km.
3.95, Candiolo, Torino; Department of Oncology, University of Turin, Candiolo

Piedmont
Puglia
Calabria
Sardinia
Campania
Southern Italy

57
Background: The fourth largest Italian city, Turin is a historical destination of young workforce migration. Regional incidence rates of gastric cancer are similar between Piedmont
and the most represented regions of immigration. However,
early-onset (diagnosis <50 years of age) gastric or gastroesophageal junction cancer (EOGGEC) is a rare disease with
distinct features and unequivocal epidemiological trends.
Methods: We present a registry analysis aimed to explore the
epidemiology of EOGGEC in Turin. A subset of EOGGEC
cases with histology clearly attributable to either Lauren subtype (diffuse or intestinal) was further explored with regard of
parental origin. Diagnoses with ICD-9 code 151 occurred
from 1985 to 2014 were extracted from the Piedmont Cancer
Registry (RTP); data on patients (pts) and parental origin
were extracted from population administrative files.
Results: Of 421 diagnoses of EOGGEC occurring in pts
ever-resident in Turin, most occurred in pts born outside
Piedmont region (64.4%, CI95% 59.8-68.9). Particularly,
54.6% (CI95% 49.9-59.4) of pts was born in Southern
regions: Puglia and Calabria amounted together to a quarter of cases (24.7%). Of 174 cases with apt histological
information, the primary was gastric in 50.0%, gastroesophageal junction in 2.3%, remaining undetermined in
47.5%. Diffuse subtype characterized 85.4% and 88.2% of
cases of pts born in Southern and in Northern Italy, respectively (p 0.66). Forty-one pts with available geographic
origin for both parents were born in Piedmont: 14 (34.1%)
and 22 (53.7%) had at least one parent from Calabria or
Puglia regions and from Southern Italy, respectively. The
share of pts that had both parents from Southern Italy was
similar to those who had both parents from Piedmont
(29.3% and 34.1%, respectively).
Conclusions: Origin from specific regions from Southern
Italy is over-represented among EOGGEC cases in Turin
city. This effect appears maintained among second-generation immigrants. Possible contributing factors include:
harsher working and living conditions; frequent provenance
from small communities; lifestyle and dietary habits.

Share of EOGGEC (CI95%)

Share of Turin residents (average
of 1990 and 2011 distributions)

Delta (absolute,
relative)

35.6% (31.1-40.2)
13.8% (10.5-17.1)
10.9% (7.9-13.9)
8.3% (5.7-11.0)
6.9% (4.5-9-3)
54.6% (49.9-59.4)

57.0%
7.8%
4.1%
1.4%
3.2%
25.0%

-21.4% (-38%)
+6.0% (+77%)
+6.9% (+169%)
+6.9% (+493%)
+3.7% (+118%)
+29.7% (119%)

C23
Association between neutropenia
and survival to nab-paclitaxel
and gemcitabine in patients with
metastatic pancreatic cancer

Catalano M.1, Roviello G.2, Mini E.2, Nobili S.2, Dreoni L.1, Ramello
M.3, Ianza A.3, Conca R.4, Aieta M.4, Gasperoni S.5, Petrioli R.6,
D'Angelo A.7
1

School of Human Health Sciences, University of Florence, Firenze;
Department of Health Sciences, University of Florence, Firenze; 3Oncology
Unit, Department of Medical, Surgical, & Health Sciences, University
2



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
Tumori Journal Abstract Book - October 2020 - 2
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Tumori Journal Abstract Book - October 2020 - Cover3
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