Tumori Journal Abstract Book - October 2020 - 56

56	
Conclusions: Despite the limited number of pts evaluated
and the restrospective nature of our analysis, our results are
in line with previous evidences, confirming the importance
of a 2nd-line combination tx, when feasible, as well in a
homogeneous population of APC pts treated with 1st-line
GemNab. On the basis of our results, ECOG PS may be
considered a prognostic factor and the choice of 2nd-line tx
should be guided in primis by the baseline general conditions of APC pts.

C20
BRCA1/2 germline analysis
in unselected pancreatic
adenocarcinoma: Experience
at the Grosseto Comprehensive
Cancer Center
Di Rocco R.1, Orrico A.2, Barucca V.3, Messinese S.4, Astorino M.4,
Bianchi P.P.5, Formisano G.5, Giuliani G.5, Salaj A.5, Salvischiani L.5,
Renieri A.6, Bengala C.4
1
Departement of Oncology, Misericordia Hospital, Grosseto; 2UOC Molecular
Medicine and Genetics AOUS; Clinical Genetics Misericordia Hospital
Grosseto, Grosseto; 3UOC Oncology San Camillo Forlanini Hospital, Roma;
4
Departement of Oncology Misericordia Hospital, Grosseto; 5Departement of
Surgery Misericordia Hospital, Grosseto; 6Departement of Medical Genetics
University of Siena, Siena

Background: Germline BRCA1/2 mutations are identified in about 4-7% of unselected patients with pancreatic
AdenoCarcinoma. NCCN Guidelines recommends to offer
genetic counseling and testing to all patients diagnosed
with AdenoCa, regardless of family history. Moreover,
patients with BRCA mutations may benefit from treatment
with platinum compounds and PARP inhibitors. Here we
report our clinical experience regarding germline
BRCA1/2 testing from 2018 to date.
Materials and methods: Genetic testing was performed
on unselected patients with pancreatic AdenoCa. DNAs,
extracted from peripheral blood, were amplified by Ion
AmpliSeq BRCA1/2 Panel and sequenced on an Ion
Torrent PGM sequencer. Every pathogenic mutation
detected was confirmed by Sanger sequencing.Testing
results were discussed at genetic-oncology multidisciplinary groups. All BRCA1/2 negative AdenoCa with important personal or family history of BRCA related cancers
will be tested for additional cancer susceptibility genes.
Results: 30 unselected patients were tested for BRCA1/2
mutations: 8 patients were diagnosed with resectable, 8
with locally advanced, 13 with metastatic disease and 1
with IPMN. Genetic tests are available on 28 patients.
BRCA1/2 gene mutations were detected in 3 patients: 2
AdenoCa (7,1%; 1 BRCA1 and 1 BRCA2) and 1 IPMN
(3.6%: BRCA2).1 BRCA2 VUS was identified. A BRCA1
mutated patient with locally advanced disease received
platinum-based neoadjuvant treatment and achieved a

Tumori Journal 106(2S)
pathological complete response. She is still disease-free
after 3 years from diagnosis. All BRCA1/2 mutated
AdenoCa patients had,additionally, personal history of
breast and ovarian cancer. No BRCA1/2 mutations was
observed in 25 patients: 7 had a family history of pancreatic and breast cancer, even at young age, and 4 had a personal history of prostate, skin and breast cancer.
Conclusions: In our series of unselected AdenoCa, the frequency of BRCA1/2 germline mutations was 7.1%, within
the range reported in the literature. One BRCA1 mutated
patients achieved a pathological complete response with
platinum-based chemotherapy and a long term diseasefree survival.Interestingly, 28% of BRCA1/2 negative
patients had family history and 16% had personal history
of BRCA related cancers. Our results confirm the importance of genetic testing in order to provide the most effective treatment and would support the literature data about
involvement of multiple genes, beyond BRCA1/2, in the
onset of hereditary pancreatic cancer.

C21
Early-onset gastric cancer: is
it really on the rise? A registrybased analysis of epidemiology
and survival
Laface R.1, Filippi R.2, Quarà V.3, Rosso S.4, Spadi R.1, Bustreo S.1,
Chiappino I.1, Satolli M.A.1, Ciuffreda L.1
1
S.C. Oncologia Medica 1 - AOU Città della Salute e della Scienza di Torino,
Torino; 2S.C. Oncologia Medica 1 - AOU Città della Salute e della Scienza
di Torino; Candiolo Cancer Institute, FPO- IRCCS-Candiolo, Torino; 3Candiolo
Cancer Institute, FPO- IRCCS-Candiolo; Department of Oncology, University
of Turin, Torino; 4Piedmont Cancer Registry - CPO Piemonte - AOU Città
della Salute e della Scienza di Torino, Torino

Background: Recent evidence suggests that early-onset
(<50 years of age) gastric carcinoma (EOGC) is a genetically
and clinically distinct disease from late-onset gastric carcinoma (LOGC). Available data on histopathology, incidence
and risk factors of EOGC are still few and conflicting.
Patients and Methods: The Piedmont Cancer Registry
(RTP) was retrospectively queried for cases of gastric and
cardias carcinoma occurred in the city of Turin, Northern
Italy, from 1985 to 2014. We present a characterization of
EOGC as for temporal trend, overall survival (OS), prognosticators, as opposed to LOGC.
Results: Among 6402 unique cases of gastric and cardias
carcinoma, diagnoses <50 years were 362 (5.7%); their
incidence decreased by 67.0% over 20 years' time (from
103 cases in the 1985-'89 period to 34 in 2010-'14), as compared to -43.4% in LOGC. A gastric primary site could be
definitely attributed to 2917 cases only; 5.9% were EOGC.
EOGG was associated with diffuse Lauren's histology (diffuse/intestinal ratio 3.2:1 vs 1.0:1 in LOGC, p<0.001);
however, rates of not retrievable histology were high in both



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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