Tumori Journal Abstract Book - October 2020 - 5

A - Thoracic Cancers	
12.7-14.4) vs Arm A with 7.5 mths (70% CI 6.9-8.9), HR
0.71 (70% CI 0.59-0.85, p=0.057). OS at 6 and 12 mths
was in Arm A 63.9% and 33.9%, and in Arm B 74.7% and
56.5%, respectively. In Arm B OS was not correlated to
TTP at first-line therapy (13.6 mths in TTP =6 mths and
13.9 mths in TTP >6 mths) and histotypes (13.8 months
in the epithelioid and 13.0 months in non-epithelioid). No
significant differences in thromboembolism G3-4 events
were observed between Arm A and Arm B (p=0.64). None
hypertension G3-4 was reported in Arm A vs 5 pts (6.3%)
in Arm B (p=0.022).
Conclusions: In the RAMES Study the addition of
Ramucirumab to Gemcitabine significantly improved OS
and can be considered a manageable regimen in 2°line
treatment of MPM pts.

A03*
Safety and activity of Combined
AVElumab with Axitinib in
unresectable or metastatic
Thymomas B3 and Thymic
carcinomas: The CAVEATT study
Conforti F.1, Pala L.1, Zucali P.2, Catania C.1, Della Vigna P.1, Pirola
S.1, Di Venosa B.1, Zagami P.1, Stucchi S.1, Pennacchioli E.1, Queirolo
P.1, De Pas T.1

5
Tumor and blood samples are collected at baseline and
whenever feasible at disease progression, to identify predictive biomarkers of response and mechanisms of resistance to treatment.
Results: 16 pts (15 TC/1 B3T) were enrolled from April
2019 to May 2020. Median age was 62 years (range 33-80).
10 pts received =2 previous line of therapies, and 6 pts
were pretreated with an anti-angiogenic drug. The median
follow-up was 7.2 months.
Out of 13 pts evaluable for response (3 pts: too early), 38%
(95% CI 17%-64%) achieved a partial response and 62%
(95% CI 35%-83%) a stable disease. The median PFS was
7.3 months (95% CI 4.2-NA).
Treatment-related adverse events (AE) of grade 1 or 2
occurred in 10 out of 16 (62%) evaluable pts, and the most
common was diarrhea. Grade ⩾3 AEs occurred in 2 (17%)
pts: G3 hyperthension leading to axitinib drug reduction
and G2 immune-related psoriasis form dermatitis, resolved
with corticosteroids treatment.
No patient stopped treatment for toxicity, 6 pts stopped for
progressive disease, 10 pts are still on treatment.
Conclusions: Preliminary results suggest promising
antitumor activity and a good toxicity profile of the
combination of axitinib and avelumab in pts with
advanced B3T and TC. Accrual is ongoing to reach the
target of 33 pts.

1

Istituto Europeo di Oncologia, Milano; 2Humanitas, Milano

Background: Patients (pts) with advanced B3 thymoma
(B3T) and thymic carcinoma (TC) resistant to chemotherapy have limited treatment options.
Treatment with Anti-PD1 showed not negligible toxicity
and limited activity, and anti-angiogenic drugs obtained
short lasting antitumor responses.
No data on combined anti-PD1/PD-L1 with antiangiogenic drugs are available in B3T/TC.
We report preliminary results on safety and activity of
avelumab-axitinib combination in this pts population.
Methods: The CAVEATT is a multicentric, phase II trial
in immunotherapy-naive pts with advanced B3T-TC, progressing after at least one line of platinum-based
chemotherapy.
Prior therapy with antiangiogenic drugs is allowed. Pts
received Avelumab 10 mg/kg iv every 2 weeks and
Axitinib 5 mg twice a day until progression or toxicity.
The primary endpoint of the study is overall response rate
(ORR) by RECIST 1.1; secondary endpoints include
ORR by irRC and ITMIG, and QoL by EORTC
QLQ-C30.
An interim futility analysis is planned after the enrollment
of the first 18 patients. If at least 5 out of 18 patients obtain
a PR, the accrual continues to reach the total number of
33 pts, according with a Simon's minimax design.

A04*
BE-PACIFIC (Italian oBsErvational
study on Patient mAnagement
strategies in real-world Clinical
practIce For patIents with
loCally advanced (stage III) NSCLC:
first Interim Analysis on the
diagnostic work-up
Silipigni S.1, Olmetto E.2, Leonetti A.3, Adamo V.4, Romano G.5,
Montrone M.6, Gridelli C.7, Morabito A.8, Tagliaferri P.9, Tonda L.10,
Ciuffreda L.11, Borghetti P.12, Allegrini G.13, Cortinovis D.14, Rossi S.15,
Scognamiglio F.16, Roncari B.17, Novello S.2, Ramella S.1
1
Università Campus Bio-Medico, Roma; 2S.S.D Oncologia Toracica, AOU
S.Luigi Gonzaga, Orbassano; 3A.O.U di Parma, Parma; 4A.O.Papardo,
Messina; 5Ospedale Vito Fazzi, Lecce; 6Ospedale Oncologico Giovanni Paolo
II, Bari; 7A.O.S.G. Moscati, Avellino; 8IRCCS G. Pascale, Napoli; 9A.O.U
Mater Domini, Catanzaro; 10Ospedale S. Giovanni Bosco, Torino; 11AOU
Città della Salute e della Scienza PO Molinette, Torino; 12ASST Spedali
Civili, Brescia; 13Ospedali Riuniti, Livorno; 14ASST San Gerardo, Monza;
15
Humanitas Research Hospital, Rozzano; 16AstraZeneca S.p.A, Basiglio
(MI); 17MediNEOS S.U.R.L., Modena

Background: Locally advanced (Stage III) disease is an
important yet controversial diagnostic subgroup, representing 25-30% of all NSCLC diagnoses, and encompasses patients with significantly different prognosis.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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