Tumori Journal Abstract Book - October 2020 - 48

48	
between PECS and PECS2 increased from 0.69 to 0.78
(95% CI:0.68-0.87) (p=0.001). In the first validation
cohort, mOS was 11.5 months,7.3 months and 3.3 months
for PECS2-0,PECS2-1 and PECS2-2, respectively (PECS20:ref HR=1; PECS2-1:HR 1.74,95% CI 1.36-2.22; PECS22:HR 3.41,95% CI 2.20-5.29; p<0.0001). In the second
validation cohort, mOS was 25.2 months,12.5 months and
3.0 months for PECS2-0,PECS2-1 and PECS2-2, respectively (PECS2-0:ref HR=1; PECS2-1:HR 2.33, 95% CI
1.32-4.13; PECS2-2:HR 8.46, 95% CI 1.50-47.7;
p<0.0001). In the third validation cohort, mOS was 11.8
months, 8.1 months and 4.6 months for PECS2-0,PECS2-1
and PECS2-2, respectively (PECS2-0:ref HR=1; PECS21:HR 1.47,95% CI 1.06-2.03; PECS2-2:HR 3.17, 95% CI
1.45-6.88; p<0.0001). Multivariate analysis in all cohorts
confirmed the PECS2 index as an independent prognostic
factor for OS.
Conclusions: The low cost, easy assessment, reproducibility and good risk-stratification performance make
PECS2 index a promising tool to assess BTC patients'
prognosis in future clinical practice.

C06
The role of response as predictor
of improved outcome in advanced
pancreatic cancer (APC) patients
(pts) treated with first-line
Gemcitabine plus Nab-paclitaxel
(GemNab)
Ribelli M.1, Bensi M.2, Di Stefano B.2, Bagalà C.2, Spring A.2, Chiaravalli
M.2, Camarda F.2, Maratta M.G.2, Tortora G.2, Salvatore L.2
1

Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico
Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore,
Roma; 2Oncologia Medica, Comprehensive Cancer Center, Fondazione
Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del
Sacro Cuore, Rome

Background: GemNab is one of the first-line standard
treatment (tx) of APC. No predictive factors, both clinical
and molecular, of benefit from this regimen exist. Two retrospective studies showed that early tumor shrinkage (ETS)
can predict an improved outcome in APC pts receiving a
first-line tx with FOLFIRINOX or GemNab. However,
data regarding GemNab, limited to a small population of
only 57 pts, seem to not confirm the association of ETS
with a better outcome. We retrospectively analysed an
homogeneous population of APC treated with first-line
GemNab at our Institution, investigating the impact of several clinical factors, including response and ETS.
Methods: APC pts receiving a first-line tx with GemNab
were included in the analysis. The association of RECIST
response and ETS with PFS and OS was evaluated. The following variables were collected: gender; age (> vs = 55
years and = vs < 70 years); baseline ECOG PS; Ca 19.9

Tumori Journal 106(2S)
baseline level (= vs < 200); anamnesis of diabetes; site of
primary tumor (head/uncinate process vs body/tail); locally
A vs metastatic (m) PC; synchronous vs metachronous;
number of m sites (1 vs >1); m sites (liver, peritoneum,
lung, nodes); number of tx lines (1 vs >1). Univariate and
multivariate analyses for PFS and OS were performed.
Results: A total of 184 APC pts receiving first-line
GemNab at our Institution from February 2014 to May
2019 were included in the analysis. RR and ETS were
assessed in 174 and 168 pts, respectively. RR was 30%,
disease control rate (DCR) 63% and ETS was 24%.
Responders had a significant better PFS (12.5 vs 5.7
months, p < 0.0001) and OS (25.1 vs 12.1 months, p <
0.0001). ETS was associated with improved PFS (12.3 vs
6.2 months, p < 0.0001) and OS (24.0 vs 12.8 months, p
< 0.0001). At the multivariate analysis a significant association with survival parameters was confirmed for
RECIST response, but not for ETS. At the multivariate
analysis, also metachronous disease and number of tx lines
>1 were independently associated with better OS.
Conclusions: Despite its retrospective nature, this is one
of the largest series of APC pts treated with first-line
GemNab investigating the role of RECIST response and
ETS in predicting outcome. On the basis of our results,
RECIST response may be considered a positive prognostic
factor, whereas ETS does not. In conclusion, achieving
tumor shrinkage, not necessarily early, significantly delays
PC progression and prolongs survival in pts treated with
first-line GemNab.

C07
MMR, PD-L1 and EBV status in
advanced gastric cancer (AGC):
Prevalence, clinicopathologic
features and treatment response
Riggi M.L.1, Salati M.2, Bocconi A.2, Rimini M.2, Riccò B.2, Santini
C.2, Canino F.2, Rovesti G.2, Caputo F.2, Reggiani Bonetti L.2, Benatti
S.2, Casade Gardini A.2, Gelsomino F.2, Luppi G.2, Dominici M.2,
Spallanzani A.2
1
Azienda Ospedaliero-Universitaria di Modena, Modena; 2Azienda
Ospedaliero - Universitaria Modena, Modena

Background: Recent reports provided initial evidence on
the clinical exploitation of the TGCA classification, suggesting MSI-h and EBV-positive as predictors of response
to immune checkpoint blockade (ICI). Moreover, incremental PD-L1 expression has been correlated to higher
chance of benefit from ICI. However, the exact prevalence
of these biomarkers as well as their association with clinicopathologic features and treatment response is largely
unknown in the real-world setting.
Methods: Pretreatment tumour tissue of AGC followed at
our Institution between January 2016 and April 2020 were



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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