Tumori Journal Abstract Book - October 2020 - 43

B - Gastrointestinal (Colorectal) Cancers	
Background: TAS-102 (trifluridine-tipiracil) has shown a
significant overall survival benefit in patients with chemorefractory metastatic colorectal cancer. According preliminar
data of a several studies about the combination of TAS-102
plus bevacizumab in patients with chemorefractory metastatic colorectal cancer, we aimed to evaluate the efficacy of
TAS-102 plus bevacizumab in patients in III line therapy for
metastatic colorectal cancer in our institution.
Methods: This is a single-arm, open-label, prospective on
going trial conducted in UOC Oncologia Medica AOUS.
The study regimen comprised 28-day cycles with biweekly
oral administration of TAS-102 (35 mg/m2 twice daily on
days 1-5 and 15-19 of every 28-day cycle) and bevacizumab (5.0 mg/kg on days 1 and 15). The primary end
point is the PFS; secondary end points include response
rate (RR), OS,and grade ⩾3 neutropenia.
The main inclusion criteria were histopathologically confirmed metastatic colorectal cancer refractory or intolerant
to a fluoropyrimidine, irinotecan, oxaliplatin, and cetuximab or panitumumab (only for RAS wild-type), and WHO
performance status of 0 or 1. Previous therapy with bevacizumab, aflibercept, ramucirumab, or regorafenib was
allowed but not mandatory.
Findings: From July 24, 2017 15 patients were assigned to
TAS-102 plus bevacizumab (n=15). After a median followup of 100 months (IQR 6,8 -14,0) median progression-free
survival was 4.75 months (3,0-6,5), (hazard ratio 0,45 [95%
CI 0,29-0,72]; p=0,0015). The most frequent grade 3 or
worse adverse event was neutropenia 10 [67%] of 15
patients treated. No deaths were deemed treatment related.
Interpretation: In patients with chemorefractory metastatic colorectal cancer, TAS-102 plus bevacizumab, was
associated with a significant and relevant improvement in
progression-free survival with tolerable toxicity. These
results are encouraging, we aim to treat more patients to
confirm these data. The combination of TAS-102 plus bevacizumab could be a new treatment option for patients
with refractory metastatic colorectal cancer.

B26
Bevacizumab plus FOLFOX-4
combined with deep regional
hyperthermia as first-line therapy
in metastatic colon cancer: a
pilot study
Gadaleta C.D.1, Laface C.1, Laforgia M.2, De Summa S.3, Porcelli
M.1, Macina F.1, Molinari P.1, Alessandra D.P.4, Ferrari C.4, Rubini
G.4, Ammendola M.5, Ranieri G.1
1
Interventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo
II", Bari, Italy; 2Pharmacology Unit, IRCCS Istituto Tumori "G. Paolo II", Bari,
Italy; 3Molecular and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo
II", Bari, Italy; 4Nuclear Medicine Unit, D.I.M, University of Bari, Bari, Italy;
5
Department of Health Science, Digestive Surgery Unit, University "Magna
Graecia" Medical School, Catanzaro, Italy

43
Background: Bevacizumab plus FOLFOX-4 regimen
represents the first-line therapy in patients affected by metastatic colorectal cancer (mCRC). Hyperthermia has been
considered an effective ancillary treatment for cancer therapy through several anti-tumour mechanisms, sharing with
Bevacizumab the inhibition of angiogenesis. Up to now,
scientific literature offers very few clinical data on the
combination of bevacizumab plus oxaliplatin-based chemotherapy with deep regional hyperthermia (DRHT) for
metastatic colon cancer (mCC) patients. Therefore, we
aimed at evaluating the efficacy of this combination based
on the possible interaction between the DRHT and
Bevacizumab anti-tumour mechanisms.
Patients and Methods: We conducted a retrospective
analysis on 40 patients affected by mCC treated with the
combination of Bevacizumab plus FOLFOX-4 (fluorouracil/folinic acid plus oxaliplatin) and DRHT (EHY2000),
between January 2017 and May 2020. DRHT treatment
was performed weekly, with capacitive electrodes at
80-110W for 50 min, during and between subsequent bevacizumab administrations. Treatment response assessment
was performed, according to the Response Evaluation
Criteria for Solid Tumors (RECIST). The primary endpoints were disease control rate (DCR) and progressionfree survival (PFS). The secondary endpoint was overall
survival (OS). DCR, counted as the percentage of patients
who had the best response rating [complete response (CR),
partial response (PR), or stable disease (SD)], was assessed
at 90 days (timepoint-1) and at 180 days (timepoint-2).
Results: DCR was 95% and 89,5% at timepoint-1 and
timepoint-2, respectively. The median PFS was 12,1
months, whereas the median OS was 21,4 months. No
major toxicity related to DRHT was registered; overall,
this combination regimen was safe.
Conclusions: Our results suggest that the combined treatment
of DHRT with Bevacizumab plus FOLFOX-4 as first-line
therapy in mCC is feasible and effective with a favourable disease control, prolonging PFS of 2,7 months with respect to
standard treatment without DRHT for mCC patients. Further
studies will be required to prove its merit and explore its
potentiality especially if compared to conventional treatment.

B27
Irinotecan monotherapy in
patients with heavily pretreated
mCRC and polymorphism of UGT1A:
a single institution case series of
magnificent benefit
Cito P.1, Cafiero C.2, Brunetti A.E.1, Lasigna M.B.1, Rinaldi A.1, Silvano
G.2, Lazzari G.2, Pisconti S.2
1

Struttura Complessa di Oncologia ASL-Taranto (Po San Pio), Castellaneta
(TA); 2Struttura Complessa di Oncologia ASL-Taranto (Po San Giuseppe
Moscati), Taranto



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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