Tumori Journal Abstract Book - October 2020 - 41

B - Gastrointestinal (Colorectal) Cancers	
Material and Methods: From January 2018 we enrolled
Patients with i) stage III-IV CRC, ii) ECOG PS ⩽ 2, iii)taking at least 5 concomitant drugs, and iv)adequate renal,
hepatic, and bone marrow function. Informed consent for
DNA extraction and pharmacogenomic analysis was provided before chemotherapy. Toxicity was graded according
to Common Terminology Criteria for Adverse Event v4.03.
Drug-PIN® is the first intelligent system that recognizes the
critical role of multiple interactions between active and/or
pro-drug forms by integrating biochemical, demographic,
and genomic data of 110 SNPs from each patient. The result
of the DDGI analysis is represented by a numerical score:
the greater the associated number, the more dangerous drugs
cocktail will be. We selected the following scores: i) DDI,
resulted from concomitant medications interactions, ii)
DrugPin1, resulted from concomitant medications and
SNPs profile; iii) DrugPin2, called as global score, resulted
from DrugPin1 added to chemotherapy drugs.
Results: Eighteen patients, with a median age of 74 years
(range 60-79), 61% male, 56% with a Charlson comorbidity index >8, and taking a median number of 7 concomitant medications (range 5-9) were included in this study.
Overall, the median value of DrugPin1 and DrugPin2 was
43 (range 11-180) and 78 (range 17-200), respectively. In
6 (33%) patients the DrugPin2 score was 2-fold higher
than DrugPin1 score. Four out of these 6 patients reported
severe toxicity that required hospitalization: two for cardiotoxicity, one for profuse diarrhea, and the other one for
an allergic reaction to oxaliplatin. At chi-2 test for any toxicity, thyroid hormone replacement therapy (P = 0.034)
and a doubled Drugpin2 score (P = 0.001) were significantly related to G3-4 toxicity.
Conclusions: Drug-PIN® could be very useful in the new
era of personalized medicine in order to prevent severe
adverse events, decrease hospitalizations, and improve
survival in cancer Patients. Further confirmatory analyses
will be done.

41
Materials and methods : We evaluated 70 patients with liver
metastases over an 8-year period with a minimum follow-up
of 24 months. We have included patients with synchronous,
methachronic R0 liver resection after induction chemotherapy, and patients with primitive colorectal cancer resection
without or partial treatment on liver metastases, R2, and
patients with palliative surgery, pulmonary metastases, peritoneal carcinosis (except minimum peritumoral spread). We
performed an overall survival analysis on all patients.
Results: We had 34 patients who underwent synchronous
and metachronous liver resection. 36 patients underwent
resection of primitive with R2 on metastases. We had 12 rectal cancers 14 right colon cancers and 8 left colon cancers in
the group of resected R0. We had 8 rectal cancers 10 right
colon cancers, 18 left colon colon cancer in the R2 patient
group. The mean survival for tumors with R0 liver resection
was 32 months for the rectum, 25 months for the right colon,
47 months for the left colon. The mean survival for R2 resections was 18 months for the rectum, 12 months for the right
colon, 20 months for the left colon. Analyzing Kaplan Meier
curves we see a worse survival of metastatic resected tumors
of the rectum compared to the left colon even if not statistically significant p = 0.2. There is instead a survival curve
superimposable with tumors of the right colon p = 0.93. The
left colon with liver resection R0 has a better survival than
the right colon even if not statistically significant p = 0.38.
Analyzing the survival between the rectum with hepatic
resection R0 vs the rectum with resection R2, the survival
in pz with R0 is statistically significant superior p = 0.02.,
Similarly it occurs in the left colon with high significance
p = 0.007. On the right instead, in the comparison between
radical surgery and R2 the advantage is obviously for radical surgery p = 0.2 but it does not reach the statistical significance of the rectal / colon left group.
Conclusions: Rectal tumors with liver metastases with R0
resection after induction chemotherapy have a lower survival than left colon cancers resected R0. They have a survival comparable to the cancers of the right colon with
resected liver metastasis.

B22
The site of primary colorectal
cancer: impact on survival of
liver metastasis resection after
induction chemotherapy
Mancarella S.1, Poti' O.2, De Giorgi D.3, Rizzo A.4, De Maria G.5
1

PO Santa Caterina Novella ASL Lecce UO Oncologia Medica, Galatina; 2PO
San Giuseppe da Copertino UO Chirurgia, Copertino; 3PO San Giuseppe
da Copertino UO Ghirurgia, Copertino; 4PO Santa Caterina Novella UO
Radiologia, Galatina; 5PO Santa Caterina Novella UO Oncologia, Galatina

B23
A retrospective study of shorter
adjuvant oxaliplatin-based
chemotherapy for high risk stage
II and stage III colon cancer
Cogoni A.A.1, Pazzola A.1, Scotto T.1, Cuccu A.S.1, Fadda G.M.1,
Contu M.2, Erbetta E.3
1

Background: The primary tumor site is currently being
evaluated as a prognostic factor in liver metastases of colorectal cancer. In this work we wanted to see the survival
between right and left tumors (including the rectum) with
liver metastases.

UO Oncologia AOU Sassari, Sassari; 2CPDI ASSL Sassari ATS Sardegna,
Sassari; 3Medicina e Chirurgia Università di Sassari, Sassari

Background: 6 months adjuvant chemotherapy (CT) with
oxaliplatin (OXA) plus fluoropyrimidines (FP) is regarded
as the standard treatment for high risk stage II or stage III



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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