Tumori Journal Abstract Book - October 2020 - 36

36	

B13
Baseline radiomics features
(RF) in metastatic colorectal
cancer (mCRC): correlation with
m site and clinical-pathological
characteristics
Camarda F.1, Boldrini L.2, Lenkowicz J.3, Caliolo G.4, Vivolo R.1,
Anghelone A.1, Di Stefano B.1, Calegari M.A.1, Pozzo C.1, Basso M.1,
Liguori C.1, De Gaetano A.M.2, Dinapoli N.2, Manfredi R.2, Valentini
V.2, Tortora G.1, Salvatore L.1
1

Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico
Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore,
Roma; 2Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica
ed Ematologia, Fondazione Policlinico Universitario, Roma; 3Istituto di
Radiologia, Università Cattolica del Sacro Cuore, Roma; 4Istituto di Radiologia,
Università Cattolica del Sacro Cuore, Roma

Background: R is an emerging field of research based on
extraction of a large amount of F from biomedical images
and on computed analysis algorithms of tumor architecture.
Few data regarding mCRC are available and no correlation
of baseline RF both with m sites and clinical-pathological
characteristics was so far investigated.
Methods: Baseline chest-abdomen CT scans of mCRC
patients (pts) were retrospectively analysed. RF were
extracted from Regions of Interest (ROI) delineated on CT
scan from each m sites, including primary tumor, when on
site. The association of specific F and disease site (liver,
lung, nodes, peritoneum and on-site primary tumor) was
investigated. Sites similarity was assessed with Principal
Component Analysis, an unsupervised learning technique to
identify patterns and clusters. Then RFs were tested individually for correlation with clinical-pathological covariates
of interest (gender, CEA level, synchronous disease, RAS/
BRAF status, mucinous histology, grading, number of m
site, primary tumor site). Wilcoxon-Mann-Whitney test was
used for this purpose (significance level set at 0.05).
Results: After RF extraction from different ROIs, dataset
was composed of 433 observations of 236 variables.
Observations referred to the number (N) of pts = 89 and the
N of ROIs = 18. RF classes were divided in statistical F
(grey-level histogram) (N of F=10); morphological F
(N=14); texture F GLCM (grey level co-occurrence matrix)
(N=100); texture F GLRLM (grey level run length matrix)
(N=66); texture F GLSZM (grey level size zone matrix)
(N=32). Regarding the association of RF with m sites, a
homogenous distribution with liver, nodes, peritoneum and
primary tumor was detected, while lung metastases showed
a different pattern for all the RF classes. A significant correlation of specific RF with clinical-pathologic characteristics
was shown, particularly with gender, CEA level, synchronous disease, mucinous histology, RAS/BRAF status.
Conclusions: Despite its retrospective nature and the limited number of pts, this is the first experience demonstrating
a different pattern of RF for lung m versus a homogeneous

Tumori Journal 106(2S)
RF distribution for the other m sites; and a significant association of specific RF with few clinical-pathologic characteristics. Our results, if confirmed in a prospective validation
set, may represent an hypothesis generator regarding the different behavior of lung m and a possible R signature able to
identify different prognostic subgroups of pts.

B14
Long term survival with
regorafenib: REALITY (Real life in
Italy) trial - a GISCAD Study
Lai E.1, Cremolini C.2, Puzzoni M.1, Bergamo F.3, Zucchelli G.2, Libertini
M.4, Dettori M.5, Banzi M.6, Boccaccino A.2, Pusceddu V.1, Cinieri S.7,
Cavo A.8, Piacentini G.9, Andreozzi F.10, Banna G.L.11, Pellino A.12,
Iachetta F.6, Rota S.13, Conca V.2, Zaniboni A.4, Scartozzi M.1
1

Medical Oncology Unit, University Hospital and University of Cagliari,
Cagliari, Italy, Cagliari; 2U.O. Oncologia Medica 2 Universitaria Ospedale
S. Chiara - Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, Pisa;
3
Unit of Medical Oncology 1, Department of Clinical and Experimental
Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy, Padova;
4
U.O. Oncologia, Fondazione Poliambulanza Istituto Ospedaliero, Brescia,
Italy, Brescia; 5Medical Oncology Unit, Azienda Ospedaliera Brotzu,
Ospedale Businco, Cagliari, Italy, Cagliari; 6SS "Sperimentazioni cliniche"
U.O. Oncologia Medica - Clinical Cancer Centre USL-IRCCS Reggio Emilia,
Reggio Emilia, Italy, Reggio Emilia; 7Medical Oncology Division & Breast
Unit, Senatore Antonio Perrino Hospital, ASL Brindisi, Brindisi, Italy, Brindisi;
8
Oncology Unit, Villa Scassi Hospital, Sampierdarena, Genova, Italy, Genova;
9
Oncologia Medica, ASST Papa Giovanni XXIII, Bergamo, Italy, Bergamo;
10
U.O.C. Oncologia, A.O.R.N. dei Colli Ospedali Monaldi-Cotugno-CTO,
Napoli, Italy, Napoli; 11Haematology/Oncology, Queen Alexandra & St Mary's
Hospitals, Portsmouth & IOW, UK, Portsmouth & IOW; 12Department
of Oncology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy;
Department of Surgery, Oncology and Gastroenterology, University of Padua,
Padua, Italy, Padova; 13Fondazione GISCAD - Gruppo Italiano per lo Studio
dei Carcinomi dell'Apparato Digerente, Vanzago, Milano

Background: Regorafenib is a key agent for metastatic
colorectal cancer (mCRC) treatment but no validated factors predicting longer survival are available.
Material (patients) and methods: REALITY was a retrospective multicentric trial in Italian refractory mCRC
patients (pts) reaching OS= 6 months (m) with regorafenib.
We aimed to assess the association between clinical parameters and outcome in the study population to define a panel
identifying long term survivors among regorafenib candidates. Primary and secondary endpoints were OS and PFS,
respectively. Statistical analysis was performed with
MedCalc (survival distribution: Kaplan-Meier method;
survival curves comparison: log-rank test).
Results: 100 regorafenib-treated mCRC pts from January
2014 to December 2015 with OS⩾6 m were enrolled.
Median OS was 11.5 m (95%CI 9,60-12,96). OS was
longer in moderately differentiated (G2) mCRC (12,4 versus [vs] 7,4 vs 9,1 m G1 vs G3; p=0,0026) and for LDH
levels ⩽217 U/l (12,1 vs 8,7 m, p=0,0470). OS was
improved with 160 mg starting dose at cycle 2 (12,4 vs



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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