Tumori Journal Abstract Book - October 2020 - 34

34	
Conclusions: Despite a higher frequency of chemotherapy
interruption or dose reduction and radiotherapy interruption, in this series of pts with LARC treated with neoadjuvant CRT, the concomitant use of statins proved to be
associated with better tumor regression, according to the
Dworak system. This hypothesis deserves further confirmation in larger prospective trials.

B10
The addition of Oxaliplatin
to neoadjuvant chemoradiotherapy in patients with
locally advanced rectal cancer:
individual patient data metaanalysis of three randomised
controlled trials with subgroup
analyses of age and stage
cohorts
Zichi C.1, Fontana E.2, Smyth E.3, Mauer M.4, Roedel C.5, Fokas
E.6, Hofheinz R.7, Arnold D.8, Schmoll H.J.9, Van Cutsem E.10,
Haustermans K.10, Stein A.11, Gerard J.12, Conroy T.13, Jouffroy-Zeller
C.14, Moehler M.15, Lordick F.16, Ben-Aharon I.17, Di Maio M.1
1
Division of Medical Oncology, University of Turin, Ordine Mauriziano
Hospital, Turin, Italy; 2Sarah Cannon Research Institute, London, United
Kingdom; 3Addenbrookes Cambridge University Hospitals NHS Foundation
Trust, Cambridge, United Kingdom; 4EORTC, Brussels, Belgium; 5Department
of Radiation Oncology, University Hospital Frankfurt, Goethe-Universität
Frankfurt, Frankfurt, Germany; 6German Cancer Consortium (DKTK)
Core Center Heidelberg and DKTK Partner Site Frankfurt, Oxford, United
Kingdom; 7University Medical Center Mannheim, Tagestherapiezentrum
am ITM, Mannheim, Germany; 8Asklepios Tumorzentrum Hamburg AK
Altona, Hamburg, Germany; 9Martin Luther University, Halle, Germany;
10
University Hospitals Gasthuisberg Leuven, KU Leuven, Leuven, Belgium;
11
University Medical Center Hamburg-Eppendorf, Department of Oncology,
Haematology, Stem Cell Transplantation and Pneumology, Hamburg,
Germany; 12Centre Antoine Lacassagne, Nice, France; 13Institut de
Cancérologie de Lorraine, Vandoeuvre-Les-Nancy, France; 14Unicancer, Paris,
France; 15University Medical Center Mainz, I. Dept. of Internal Medicine,
Mainz, Germany; 16University Cancer Center Leipzig, Leipzig, Germany;
17
Division of Oncology, Rambam Health Care Center, Haifa, Israel

Background: Neoadjuvant chemo-radiotherapy (CRT) with
fluoropyrimidine (FP) is the current standard of treatment for
locally advanced rectal cancer (LARC). Most randomised
controlled trials (RCTs) examining the addition of Oxaliplatin
(OX) were negative, but a post hoc analysis of the CAO/
ARO/AIO-04 trial showed significant benefit adding OX in
patients (pts) <60y. We hypothesized that OX-CRT might
improve outcomes in younger pts with LARC.
Methods: We performed a systematic review and individual
patient data (IPD) meta-analysis. RCTs testing the addition
of OX to standard FP-based CRT in LARC were eligible.
Primary endpoint: disease-free survival (DFS), secondary
endpoints: pathologic complete response (ypCR) and overall
survival (OS). Analyses were by intention to treat (ITT),
stratified by trial. Age cut-offs were 60y and 50y.

Tumori Journal 106(2S)
Results: Data from 3 of 9 identified RCTs were available
(CAO/ARO/AIO-04, ACCORD-12, PETACC-6), corresponding to 2914 pts (48.5% of available literature).
Median age was 63y, 40% were <60y, 12% were <50y,
72% were stage ⩾III. No significant improvement in DFS
was observed with OX in ITT (Hazard Ratio [HR] 0.88,
95%CI 0.77-1.01, p=0.06). OX significantly improved
DFS in <60y (n=1166 - HR 0.77, 95%CI 0.62-0.96,
p=0.02), whereas the improvement was not statistically significant in <50y (n=350 - HR 0.73, 95%CI 0.49-1.08,
p=0.12). There was no significant interaction with age (60y
p=0.11; 50y p=0.44). Stratifying the DFS analysis by stage
(I-II vs. ⩾III) no difference was found in all age subgroups
(Table 1). OX increased ypCR in ITT from 13% to 16%
(Odds Ratio [OR] 1.28, 95%CI 1.04-1.57, p=0.024). There
was no OS benefit (HR 0.97, 95%CI 0.82-1.15, p=0.75).
Conclusions: This IPD meta-analysis evaluating the addition of OX to CRT did not show significant interaction of
OX with age. However, data showed a signal for DFS benefit in pts <60y, with a non-significant increment in DFS
in <50y, although this analysis may be underpowered.
Stage

Age

PFS - HR

95%CI

p-value

I/II
I/II
I/II
I/II
⩾III
⩾III
⩾III
⩾III

<60
<50
>60
>50
<60
<50
>60
>50

0.64
0.67
0.89
0.81
0.81
0.72
0.97
0.93

0.39-1.03
0.30-1.51
0.66-1.25
0.62-1.06
0.63-1.04
0.46-1.14
0.80-1.19
0.79-1.10

0.06
0.34
0.46
0.12
0.10
0.16
0.78
0.38

B11
Cardiovascular events in
colorectal cancer patients
treated with fluoropyrimidines:
interim analysis of the
prospective Checkpoint trial
(NCT02665312)
Aimar G.1, Lombardi P.1, Filippi R.2, Quarà V.1, Milanesio M.C.1,
Crespi V.1, Farinea G.1, Bonzano A.3, Cavalloni G.4, Peraldo Neia
C.4, Basiricò M.4, Depetris I.5, Ferraris R.6, Leone F.7, Aglietta M.1,
Fenocchio E.6
1

Department of Oncology, University of Turin; Department of Medical
Oncology, Candiolo Cancer Institute, FPO - IRCCS, Torino; 2Centro Oncologico
Ematologico Subalpino, Azienda Universitaria Ospedaliera Città della Salute
e della Scienza di Torino Department of Oncology 10126, Torino Italy,
Torino; 3Department of Cardiology, Candiolo Cancer Institute, FPO, IRCCS,
Candiolo, Italy., Torino; 4Clinical Research Office, Candiolo Cancer Institute,
FPO - IRCCS - Candiolo, Torino; 5Ospedale di Ivrea Department of Medical
Oncology 10015, Ivrea, Italy, Torino; 6Multidisciplinary Outpatient Oncology
Clinic, Candiolo Cancer Institute FPO-IRCCS, Candiolo Torino, Italy, Torino;
7
Dipartimento di Oncologia, Ospedale degli Infermi, Biella, Italy, Biella



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
Tumori Journal Abstract Book - October 2020 - 2
Tumori Journal Abstract Book - October 2020 - 3
Tumori Journal Abstract Book - October 2020 - 4
Tumori Journal Abstract Book - October 2020 - 5
Tumori Journal Abstract Book - October 2020 - 6
Tumori Journal Abstract Book - October 2020 - 7
Tumori Journal Abstract Book - October 2020 - 8
Tumori Journal Abstract Book - October 2020 - 9
Tumori Journal Abstract Book - October 2020 - 10
Tumori Journal Abstract Book - October 2020 - 11
Tumori Journal Abstract Book - October 2020 - 12
Tumori Journal Abstract Book - October 2020 - 13
Tumori Journal Abstract Book - October 2020 - 14
Tumori Journal Abstract Book - October 2020 - 15
Tumori Journal Abstract Book - October 2020 - 16
Tumori Journal Abstract Book - October 2020 - 17
Tumori Journal Abstract Book - October 2020 - 18
Tumori Journal Abstract Book - October 2020 - 19
Tumori Journal Abstract Book - October 2020 - 20
Tumori Journal Abstract Book - October 2020 - 21
Tumori Journal Abstract Book - October 2020 - 22
Tumori Journal Abstract Book - October 2020 - 23
Tumori Journal Abstract Book - October 2020 - 24
Tumori Journal Abstract Book - October 2020 - 25
Tumori Journal Abstract Book - October 2020 - 26
Tumori Journal Abstract Book - October 2020 - 27
Tumori Journal Abstract Book - October 2020 - 28
Tumori Journal Abstract Book - October 2020 - 29
Tumori Journal Abstract Book - October 2020 - 30
Tumori Journal Abstract Book - October 2020 - 31
Tumori Journal Abstract Book - October 2020 - 32
Tumori Journal Abstract Book - October 2020 - 33
Tumori Journal Abstract Book - October 2020 - 34
Tumori Journal Abstract Book - October 2020 - 35
Tumori Journal Abstract Book - October 2020 - 36
Tumori Journal Abstract Book - October 2020 - 37
Tumori Journal Abstract Book - October 2020 - 38
Tumori Journal Abstract Book - October 2020 - 39
Tumori Journal Abstract Book - October 2020 - 40
Tumori Journal Abstract Book - October 2020 - 41
Tumori Journal Abstract Book - October 2020 - 42
Tumori Journal Abstract Book - October 2020 - 43
Tumori Journal Abstract Book - October 2020 - 44
Tumori Journal Abstract Book - October 2020 - 45
Tumori Journal Abstract Book - October 2020 - 46
Tumori Journal Abstract Book - October 2020 - 47
Tumori Journal Abstract Book - October 2020 - 48
Tumori Journal Abstract Book - October 2020 - 49
Tumori Journal Abstract Book - October 2020 - 50
Tumori Journal Abstract Book - October 2020 - 51
Tumori Journal Abstract Book - October 2020 - 52
Tumori Journal Abstract Book - October 2020 - 53
Tumori Journal Abstract Book - October 2020 - 54
Tumori Journal Abstract Book - October 2020 - 55
Tumori Journal Abstract Book - October 2020 - 56
Tumori Journal Abstract Book - October 2020 - 57
Tumori Journal Abstract Book - October 2020 - 58
Tumori Journal Abstract Book - October 2020 - 59
Tumori Journal Abstract Book - October 2020 - 60
Tumori Journal Abstract Book - October 2020 - 61
Tumori Journal Abstract Book - October 2020 - 62
Tumori Journal Abstract Book - October 2020 - 63
Tumori Journal Abstract Book - October 2020 - 64
Tumori Journal Abstract Book - October 2020 - 65
Tumori Journal Abstract Book - October 2020 - 66
Tumori Journal Abstract Book - October 2020 - 67
Tumori Journal Abstract Book - October 2020 - 68
Tumori Journal Abstract Book - October 2020 - 69
Tumori Journal Abstract Book - October 2020 - 70
Tumori Journal Abstract Book - October 2020 - 71
Tumori Journal Abstract Book - October 2020 - 72
Tumori Journal Abstract Book - October 2020 - 73
Tumori Journal Abstract Book - October 2020 - 74
Tumori Journal Abstract Book - October 2020 - 75
Tumori Journal Abstract Book - October 2020 - 76
Tumori Journal Abstract Book - October 2020 - 77
Tumori Journal Abstract Book - October 2020 - 78
Tumori Journal Abstract Book - October 2020 - 79
Tumori Journal Abstract Book - October 2020 - 80
Tumori Journal Abstract Book - October 2020 - 81
Tumori Journal Abstract Book - October 2020 - 82
Tumori Journal Abstract Book - October 2020 - 83
Tumori Journal Abstract Book - October 2020 - 84
Tumori Journal Abstract Book - October 2020 - 85
Tumori Journal Abstract Book - October 2020 - 86
Tumori Journal Abstract Book - October 2020 - 87
Tumori Journal Abstract Book - October 2020 - 88
Tumori Journal Abstract Book - October 2020 - 89
Tumori Journal Abstract Book - October 2020 - 90
Tumori Journal Abstract Book - October 2020 - 91
Tumori Journal Abstract Book - October 2020 - 92
Tumori Journal Abstract Book - October 2020 - 93
Tumori Journal Abstract Book - October 2020 - 94
Tumori Journal Abstract Book - October 2020 - 95
Tumori Journal Abstract Book - October 2020 - 96
Tumori Journal Abstract Book - October 2020 - 97
Tumori Journal Abstract Book - October 2020 - 98
Tumori Journal Abstract Book - October 2020 - 99
Tumori Journal Abstract Book - October 2020 - 100
Tumori Journal Abstract Book - October 2020 - 101
Tumori Journal Abstract Book - October 2020 - 102
Tumori Journal Abstract Book - October 2020 - 103
Tumori Journal Abstract Book - October 2020 - 104
Tumori Journal Abstract Book - October 2020 - 105
Tumori Journal Abstract Book - October 2020 - 106
Tumori Journal Abstract Book - October 2020 - 107
Tumori Journal Abstract Book - October 2020 - 108
Tumori Journal Abstract Book - October 2020 - 109
Tumori Journal Abstract Book - October 2020 - 110
Tumori Journal Abstract Book - October 2020 - 111
Tumori Journal Abstract Book - October 2020 - 112
Tumori Journal Abstract Book - October 2020 - 113
Tumori Journal Abstract Book - October 2020 - 114
Tumori Journal Abstract Book - October 2020 - 115
Tumori Journal Abstract Book - October 2020 - 116
Tumori Journal Abstract Book - October 2020 - 117
Tumori Journal Abstract Book - October 2020 - 118
Tumori Journal Abstract Book - October 2020 - 119
Tumori Journal Abstract Book - October 2020 - 120
Tumori Journal Abstract Book - October 2020 - 121
Tumori Journal Abstract Book - October 2020 - 122
Tumori Journal Abstract Book - October 2020 - 123
Tumori Journal Abstract Book - October 2020 - 124
Tumori Journal Abstract Book - October 2020 - 125
Tumori Journal Abstract Book - October 2020 - 126
Tumori Journal Abstract Book - October 2020 - 127
Tumori Journal Abstract Book - October 2020 - 128
Tumori Journal Abstract Book - October 2020 - 129
Tumori Journal Abstract Book - October 2020 - 130
Tumori Journal Abstract Book - October 2020 - 131
Tumori Journal Abstract Book - October 2020 - 132
Tumori Journal Abstract Book - October 2020 - 133
Tumori Journal Abstract Book - October 2020 - 134
Tumori Journal Abstract Book - October 2020 - 135
Tumori Journal Abstract Book - October 2020 - 136
Tumori Journal Abstract Book - October 2020 - 137
Tumori Journal Abstract Book - October 2020 - 138
Tumori Journal Abstract Book - October 2020 - 139
Tumori Journal Abstract Book - October 2020 - 140
Tumori Journal Abstract Book - October 2020 - 141
Tumori Journal Abstract Book - October 2020 - 142
Tumori Journal Abstract Book - October 2020 - 143
Tumori Journal Abstract Book - October 2020 - 144
Tumori Journal Abstract Book - October 2020 - 145
Tumori Journal Abstract Book - October 2020 - 146
Tumori Journal Abstract Book - October 2020 - 147
Tumori Journal Abstract Book - October 2020 - 148
Tumori Journal Abstract Book - October 2020 - 149
Tumori Journal Abstract Book - October 2020 - 150
Tumori Journal Abstract Book - October 2020 - 151
Tumori Journal Abstract Book - October 2020 - 152
Tumori Journal Abstract Book - October 2020 - 153
Tumori Journal Abstract Book - October 2020 - 154
Tumori Journal Abstract Book - October 2020 - 155
Tumori Journal Abstract Book - October 2020 - 156
Tumori Journal Abstract Book - October 2020 - 157
Tumori Journal Abstract Book - October 2020 - 158
Tumori Journal Abstract Book - October 2020 - 159
Tumori Journal Abstract Book - October 2020 - 160
Tumori Journal Abstract Book - October 2020 - 161
Tumori Journal Abstract Book - October 2020 - 162
Tumori Journal Abstract Book - October 2020 - 163
Tumori Journal Abstract Book - October 2020 - 164
Tumori Journal Abstract Book - October 2020 - 165
Tumori Journal Abstract Book - October 2020 - 166
Tumori Journal Abstract Book - October 2020 - 167
Tumori Journal Abstract Book - October 2020 - 168
Tumori Journal Abstract Book - October 2020 - 169
Tumori Journal Abstract Book - October 2020 - 170
Tumori Journal Abstract Book - October 2020 - 171
Tumori Journal Abstract Book - October 2020 - 172
Tumori Journal Abstract Book - October 2020 - 173
Tumori Journal Abstract Book - October 2020 - 174
Tumori Journal Abstract Book - October 2020 - 175
Tumori Journal Abstract Book - October 2020 - 176
Tumori Journal Abstract Book - October 2020 - 177
Tumori Journal Abstract Book - October 2020 - 178
Tumori Journal Abstract Book - October 2020 - 179
Tumori Journal Abstract Book - October 2020 - 180
Tumori Journal Abstract Book - October 2020 - 181
Tumori Journal Abstract Book - October 2020 - 182
Tumori Journal Abstract Book - October 2020 - 183
Tumori Journal Abstract Book - October 2020 - 184
Tumori Journal Abstract Book - October 2020 - 185
Tumori Journal Abstract Book - October 2020 - 186
Tumori Journal Abstract Book - October 2020 - 187
Tumori Journal Abstract Book - October 2020 - 188
Tumori Journal Abstract Book - October 2020 - 189
Tumori Journal Abstract Book - October 2020 - 190
Tumori Journal Abstract Book - October 2020 - 191
Tumori Journal Abstract Book - October 2020 - 192
Tumori Journal Abstract Book - October 2020 - 193
Tumori Journal Abstract Book - October 2020 - 194
Tumori Journal Abstract Book - October 2020 - 195
Tumori Journal Abstract Book - October 2020 - 196
Tumori Journal Abstract Book - October 2020 - 197
Tumori Journal Abstract Book - October 2020 - 198
Tumori Journal Abstract Book - October 2020 - 199
Tumori Journal Abstract Book - October 2020 - 200
Tumori Journal Abstract Book - October 2020 - 201
Tumori Journal Abstract Book - October 2020 - 202
Tumori Journal Abstract Book - October 2020 - 203
Tumori Journal Abstract Book - October 2020 - 204
Tumori Journal Abstract Book - October 2020 - 205
Tumori Journal Abstract Book - October 2020 - 206
Tumori Journal Abstract Book - October 2020 - 207
Tumori Journal Abstract Book - October 2020 - 208
Tumori Journal Abstract Book - October 2020 - 209
Tumori Journal Abstract Book - October 2020 - 210
Tumori Journal Abstract Book - October 2020 - 211
Tumori Journal Abstract Book - October 2020 - 212
Tumori Journal Abstract Book - October 2020 - 213
Tumori Journal Abstract Book - October 2020 - 214
Tumori Journal Abstract Book - October 2020 - 215
Tumori Journal Abstract Book - October 2020 - 216
Tumori Journal Abstract Book - October 2020 - 217
Tumori Journal Abstract Book - October 2020 - 218
Tumori Journal Abstract Book - October 2020 - 219
Tumori Journal Abstract Book - October 2020 - 220
Tumori Journal Abstract Book - October 2020 - 221
Tumori Journal Abstract Book - October 2020 - 222
Tumori Journal Abstract Book - October 2020 - 223
Tumori Journal Abstract Book - October 2020 - 224
Tumori Journal Abstract Book - October 2020 - 225
Tumori Journal Abstract Book - October 2020 - 226
Tumori Journal Abstract Book - October 2020 - 227
Tumori Journal Abstract Book - October 2020 - 228
Tumori Journal Abstract Book - October 2020 - 229
Tumori Journal Abstract Book - October 2020 - 230
Tumori Journal Abstract Book - October 2020 - 231
Tumori Journal Abstract Book - October 2020 - 232
Tumori Journal Abstract Book - October 2020 - 233
Tumori Journal Abstract Book - October 2020 - 234
Tumori Journal Abstract Book - October 2020 - 235
Tumori Journal Abstract Book - October 2020 - Cover3
Tumori Journal Abstract Book - October 2020 - Cover4
https://www.nxtbookmedia.com