Tumori Journal Abstract Book - October 2020 - 33

B - Gastrointestinal (Colorectal) Cancers	
1

Azienda Ospedali Riuniti Marche Nord - Unità di oncologia Medica, Pesaro;
Università di Pisa, Pisa; 3Istituto Oncologico Veneto IOV - IRCCS, Pisa;
4
San Bortolo General Hospital, Vicenza; 5Università Campus Bio-Medico,
Roma; 6Card. G. Panico Hospital, Tricase; 7IRCCS Casa Sollievo della
Sofferenza, San Giovanni Rotondo; 8Università degli Studi di Milano, Milano;
9
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola;
10
Università di Pisa, Pisa; 11Fondazione Poliambulanza, Brescia; 12Universita
degli Studi di Urbino Carlo Bo, Fano
2

Background: Loss of p53 tumor suppressor function has
been associated with chemoresistance and poor prognosis
in cancer pts. New experimental and clinical data have
identified p53 as a master regulator in tumor angiogenesis.
A highly conserved functional p53-binding site has been
identified within the VEGF promoter and p53 down-regulates vascular endothelial growth factor (VEGF) expression. Disruptive TP53 mutations impair p53 tumor
suppressor functions and increase VEGF expression levels
in human cancer tissues. This background prompted us to
analyze the clinical impact of TP53 in mCRC patients (pts)
enrolled in the TRIBE-2 trial.
Methods: TRIBE-2 is a prospective phase III trial in
which untreated mCRC pts were randomized to receive
first-line FOLFOX or FOLFOXIRI plus Bev followed by
FOLFIRI or FOLFOXIRI re-introduction plus Bev after
first disease progression. TP53 mutations were identified
by next-generation sequencing in primary tumors. Each
TP53 missense mutation was assigned a residual transcriptional activity score (TP53RTAS) according to the
results of a site-directed mutagenesis technique and
yeast-based functional assay. Overall survival (OS) and
first progression-free survival (PFS1) times were correlated with TP53 status: A) wild-type; B) TP53RTAS=10%
missense mutation; C) TP53RTAS<10% missense mutations or truncating non-missense mutations (nonsense
and frameshift).
Results: Tumor samples for TP53 analysis were collected from 278 pts (arm A/B 152/126) out of 679 pts
enrolled in the TRIBE-2 study. RAS/RAF mutations
were found in 177/38 pts. According to TP53 analysis,
groups A, B and C pts were 51 (18%), 31 (11%) and 196
(71%), respectively. Median OS times in groups A, B and
C were 30.4 months (95%CI 25.7-38.6 months), 29.8
months (95%CI 28.3-35 months) and 21.2 months
(p5%CI 18.7-24.4 months), respectively (p=0.003).
Median PFS1 times in groups A, B and C were 15.8
months (95%CI 11.9-19.6 months), 12.1 months (95%CI
9.5-16.3 months) and 10 months (95%CI 8.4-11.1
months), respectively (p=0.006). The detrimental effect
of the TP53 group C status was retained in OS/PFS1 multivariate models. Tumor response analysis did not show
significant association with TP53 mutations.
Conclusions: In mCRC pts treated with CT plus Bev, the
TP53 mutational status including deleterious missense and
truncating non-missense mutations negatively impacts on
survival outcomes. Alternative therapeutics should be
explored in this clinically unfavorable group of mCRC pts.

33

B09
Statins increase pathological
response in locally advanced
rectal cancer (LARC) treated
with chemo-radiation (CRT): a
multicentric experience
Caputo F.1, Santini C.1, Casadei-Gardini A.1, Cerma K.1, Bardasi C.1,
Garajovà I.2, Lattanzi E.3, Passardi A.4, Rapposelli I.G.4, Spallanzani
A.1, Reggiani Bonetti L.5, Gelmini R.6, Meduri B.7, Piccoli M.8, Pecchi
A.9, Benatti S.1, Dominici M.1, Luppi G.1, Gelsomino F.1
1

University Hospital of Modena, Division of Oncology, Modena., Modena;
University Hospital of Parma, Medical Oncology Unit, Parma., Parma;
3
University Hospital of Parma, Radiotherapy Unit, Parma., Parma;
4
Department of Medical Oncology, Istituto Scientifico Romagnolo per lo
Studio e la Cura dei Tumori (IRST) IRRCS, Meldola, Meldola; 5University
Hospital of Modena, Section of Pathology, Modena., Modena; 6University
Hospital of Modena, Department of Surgery, Modena., Modena; 7University
Hospital of Modena, Radiotherapy Unit, Modena., Modena; 8Azienda
Ospedaliero-Universitaria of Modena, Department of Surgery, OCB
(Ospedale Civile Baggiovara), Modena., Modena; 9University Hospital of
Modena, Department of Radiology, Modena., Modena
2

Background: Complete tumor response to neoadjuvant
chemo-radiation (CRT) for locally advanced rectal cancer
(LARC) is associated with better outcomes. Unfortunately,
it is achieved in only 20-30% of patients (pts). Many studies evaluated the potential role of concomitant medications
in addition to CRT to enhance response rate, but data are
not definitive. In this multicentric, retrospective study, we
investigated the influence of various concomitant medications on outcomes of pts undergoing CRT for LARC.
Material and methods: 246 pts treated at Azienda
Ospedaliero-Universitaria of Modena, University of Parma,
and Istituto Scientifico Romagnolo per lo Studio e la Cura
dei Tumori between 2003 and 2018 were retrospectively
identified. Demographical and clinicopathological data of
potential interest were collected. The association between
the use of concomitant drugs and outcomes (Dworak tumor
regression grade [TRG] and disease-free survival [DFS])
was assessed by Odds Ratio (OR).
Results: Globally, 246 pts received neoadjuvant CRT. Of
them, 15.8% were taking antihypertensive drugs, 3.7%
statins, 1.2% antiplatelet drugs, and 1.6% antidiabetic drugs.
Furthermore, 30.5% of pts were taking ⩾ 2 of these drugs
simultaneously. 40% of pts have experienced CRT-related
toxicity, leading to a dose reduction or treatment discontinuation in 27% of cases. Of the 221 surgical specimens available, a Dworak TRG score of 3-4 was found in 68 (30.7%)
pts. At both univariate and multivariate analysis, an association between statins and a Dworak grade 3-4 was found (OR
8.78, 95% CI 1.57-49.15, p=0.01). Moreover, statins were
significantly associated with more frequently CRT-related
toxicity (OR 2.39, 95% CI 1.23-4.64, p=0.0098) and a more
frequent chemotherapy dose reduction or discontinuation
(OR 2.26, 95% CI 1.06-4.80, p=0.03). No correlations were
found between the use of the evaluated drugs and the DFS.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
Tumori Journal Abstract Book - October 2020 - 2
Tumori Journal Abstract Book - October 2020 - 3
Tumori Journal Abstract Book - October 2020 - 4
Tumori Journal Abstract Book - October 2020 - 5
Tumori Journal Abstract Book - October 2020 - 6
Tumori Journal Abstract Book - October 2020 - 7
Tumori Journal Abstract Book - October 2020 - 8
Tumori Journal Abstract Book - October 2020 - 9
Tumori Journal Abstract Book - October 2020 - 10
Tumori Journal Abstract Book - October 2020 - 11
Tumori Journal Abstract Book - October 2020 - 12
Tumori Journal Abstract Book - October 2020 - 13
Tumori Journal Abstract Book - October 2020 - 14
Tumori Journal Abstract Book - October 2020 - 15
Tumori Journal Abstract Book - October 2020 - 16
Tumori Journal Abstract Book - October 2020 - 17
Tumori Journal Abstract Book - October 2020 - 18
Tumori Journal Abstract Book - October 2020 - 19
Tumori Journal Abstract Book - October 2020 - 20
Tumori Journal Abstract Book - October 2020 - 21
Tumori Journal Abstract Book - October 2020 - 22
Tumori Journal Abstract Book - October 2020 - 23
Tumori Journal Abstract Book - October 2020 - 24
Tumori Journal Abstract Book - October 2020 - 25
Tumori Journal Abstract Book - October 2020 - 26
Tumori Journal Abstract Book - October 2020 - 27
Tumori Journal Abstract Book - October 2020 - 28
Tumori Journal Abstract Book - October 2020 - 29
Tumori Journal Abstract Book - October 2020 - 30
Tumori Journal Abstract Book - October 2020 - 31
Tumori Journal Abstract Book - October 2020 - 32
Tumori Journal Abstract Book - October 2020 - 33
Tumori Journal Abstract Book - October 2020 - 34
Tumori Journal Abstract Book - October 2020 - 35
Tumori Journal Abstract Book - October 2020 - 36
Tumori Journal Abstract Book - October 2020 - 37
Tumori Journal Abstract Book - October 2020 - 38
Tumori Journal Abstract Book - October 2020 - 39
Tumori Journal Abstract Book - October 2020 - 40
Tumori Journal Abstract Book - October 2020 - 41
Tumori Journal Abstract Book - October 2020 - 42
Tumori Journal Abstract Book - October 2020 - 43
Tumori Journal Abstract Book - October 2020 - 44
Tumori Journal Abstract Book - October 2020 - 45
Tumori Journal Abstract Book - October 2020 - 46
Tumori Journal Abstract Book - October 2020 - 47
Tumori Journal Abstract Book - October 2020 - 48
Tumori Journal Abstract Book - October 2020 - 49
Tumori Journal Abstract Book - October 2020 - 50
Tumori Journal Abstract Book - October 2020 - 51
Tumori Journal Abstract Book - October 2020 - 52
Tumori Journal Abstract Book - October 2020 - 53
Tumori Journal Abstract Book - October 2020 - 54
Tumori Journal Abstract Book - October 2020 - 55
Tumori Journal Abstract Book - October 2020 - 56
Tumori Journal Abstract Book - October 2020 - 57
Tumori Journal Abstract Book - October 2020 - 58
Tumori Journal Abstract Book - October 2020 - 59
Tumori Journal Abstract Book - October 2020 - 60
Tumori Journal Abstract Book - October 2020 - 61
Tumori Journal Abstract Book - October 2020 - 62
Tumori Journal Abstract Book - October 2020 - 63
Tumori Journal Abstract Book - October 2020 - 64
Tumori Journal Abstract Book - October 2020 - 65
Tumori Journal Abstract Book - October 2020 - 66
Tumori Journal Abstract Book - October 2020 - 67
Tumori Journal Abstract Book - October 2020 - 68
Tumori Journal Abstract Book - October 2020 - 69
Tumori Journal Abstract Book - October 2020 - 70
Tumori Journal Abstract Book - October 2020 - 71
Tumori Journal Abstract Book - October 2020 - 72
Tumori Journal Abstract Book - October 2020 - 73
Tumori Journal Abstract Book - October 2020 - 74
Tumori Journal Abstract Book - October 2020 - 75
Tumori Journal Abstract Book - October 2020 - 76
Tumori Journal Abstract Book - October 2020 - 77
Tumori Journal Abstract Book - October 2020 - 78
Tumori Journal Abstract Book - October 2020 - 79
Tumori Journal Abstract Book - October 2020 - 80
Tumori Journal Abstract Book - October 2020 - 81
Tumori Journal Abstract Book - October 2020 - 82
Tumori Journal Abstract Book - October 2020 - 83
Tumori Journal Abstract Book - October 2020 - 84
Tumori Journal Abstract Book - October 2020 - 85
Tumori Journal Abstract Book - October 2020 - 86
Tumori Journal Abstract Book - October 2020 - 87
Tumori Journal Abstract Book - October 2020 - 88
Tumori Journal Abstract Book - October 2020 - 89
Tumori Journal Abstract Book - October 2020 - 90
Tumori Journal Abstract Book - October 2020 - 91
Tumori Journal Abstract Book - October 2020 - 92
Tumori Journal Abstract Book - October 2020 - 93
Tumori Journal Abstract Book - October 2020 - 94
Tumori Journal Abstract Book - October 2020 - 95
Tumori Journal Abstract Book - October 2020 - 96
Tumori Journal Abstract Book - October 2020 - 97
Tumori Journal Abstract Book - October 2020 - 98
Tumori Journal Abstract Book - October 2020 - 99
Tumori Journal Abstract Book - October 2020 - 100
Tumori Journal Abstract Book - October 2020 - 101
Tumori Journal Abstract Book - October 2020 - 102
Tumori Journal Abstract Book - October 2020 - 103
Tumori Journal Abstract Book - October 2020 - 104
Tumori Journal Abstract Book - October 2020 - 105
Tumori Journal Abstract Book - October 2020 - 106
Tumori Journal Abstract Book - October 2020 - 107
Tumori Journal Abstract Book - October 2020 - 108
Tumori Journal Abstract Book - October 2020 - 109
Tumori Journal Abstract Book - October 2020 - 110
Tumori Journal Abstract Book - October 2020 - 111
Tumori Journal Abstract Book - October 2020 - 112
Tumori Journal Abstract Book - October 2020 - 113
Tumori Journal Abstract Book - October 2020 - 114
Tumori Journal Abstract Book - October 2020 - 115
Tumori Journal Abstract Book - October 2020 - 116
Tumori Journal Abstract Book - October 2020 - 117
Tumori Journal Abstract Book - October 2020 - 118
Tumori Journal Abstract Book - October 2020 - 119
Tumori Journal Abstract Book - October 2020 - 120
Tumori Journal Abstract Book - October 2020 - 121
Tumori Journal Abstract Book - October 2020 - 122
Tumori Journal Abstract Book - October 2020 - 123
Tumori Journal Abstract Book - October 2020 - 124
Tumori Journal Abstract Book - October 2020 - 125
Tumori Journal Abstract Book - October 2020 - 126
Tumori Journal Abstract Book - October 2020 - 127
Tumori Journal Abstract Book - October 2020 - 128
Tumori Journal Abstract Book - October 2020 - 129
Tumori Journal Abstract Book - October 2020 - 130
Tumori Journal Abstract Book - October 2020 - 131
Tumori Journal Abstract Book - October 2020 - 132
Tumori Journal Abstract Book - October 2020 - 133
Tumori Journal Abstract Book - October 2020 - 134
Tumori Journal Abstract Book - October 2020 - 135
Tumori Journal Abstract Book - October 2020 - 136
Tumori Journal Abstract Book - October 2020 - 137
Tumori Journal Abstract Book - October 2020 - 138
Tumori Journal Abstract Book - October 2020 - 139
Tumori Journal Abstract Book - October 2020 - 140
Tumori Journal Abstract Book - October 2020 - 141
Tumori Journal Abstract Book - October 2020 - 142
Tumori Journal Abstract Book - October 2020 - 143
Tumori Journal Abstract Book - October 2020 - 144
Tumori Journal Abstract Book - October 2020 - 145
Tumori Journal Abstract Book - October 2020 - 146
Tumori Journal Abstract Book - October 2020 - 147
Tumori Journal Abstract Book - October 2020 - 148
Tumori Journal Abstract Book - October 2020 - 149
Tumori Journal Abstract Book - October 2020 - 150
Tumori Journal Abstract Book - October 2020 - 151
Tumori Journal Abstract Book - October 2020 - 152
Tumori Journal Abstract Book - October 2020 - 153
Tumori Journal Abstract Book - October 2020 - 154
Tumori Journal Abstract Book - October 2020 - 155
Tumori Journal Abstract Book - October 2020 - 156
Tumori Journal Abstract Book - October 2020 - 157
Tumori Journal Abstract Book - October 2020 - 158
Tumori Journal Abstract Book - October 2020 - 159
Tumori Journal Abstract Book - October 2020 - 160
Tumori Journal Abstract Book - October 2020 - 161
Tumori Journal Abstract Book - October 2020 - 162
Tumori Journal Abstract Book - October 2020 - 163
Tumori Journal Abstract Book - October 2020 - 164
Tumori Journal Abstract Book - October 2020 - 165
Tumori Journal Abstract Book - October 2020 - 166
Tumori Journal Abstract Book - October 2020 - 167
Tumori Journal Abstract Book - October 2020 - 168
Tumori Journal Abstract Book - October 2020 - 169
Tumori Journal Abstract Book - October 2020 - 170
Tumori Journal Abstract Book - October 2020 - 171
Tumori Journal Abstract Book - October 2020 - 172
Tumori Journal Abstract Book - October 2020 - 173
Tumori Journal Abstract Book - October 2020 - 174
Tumori Journal Abstract Book - October 2020 - 175
Tumori Journal Abstract Book - October 2020 - 176
Tumori Journal Abstract Book - October 2020 - 177
Tumori Journal Abstract Book - October 2020 - 178
Tumori Journal Abstract Book - October 2020 - 179
Tumori Journal Abstract Book - October 2020 - 180
Tumori Journal Abstract Book - October 2020 - 181
Tumori Journal Abstract Book - October 2020 - 182
Tumori Journal Abstract Book - October 2020 - 183
Tumori Journal Abstract Book - October 2020 - 184
Tumori Journal Abstract Book - October 2020 - 185
Tumori Journal Abstract Book - October 2020 - 186
Tumori Journal Abstract Book - October 2020 - 187
Tumori Journal Abstract Book - October 2020 - 188
Tumori Journal Abstract Book - October 2020 - 189
Tumori Journal Abstract Book - October 2020 - 190
Tumori Journal Abstract Book - October 2020 - 191
Tumori Journal Abstract Book - October 2020 - 192
Tumori Journal Abstract Book - October 2020 - 193
Tumori Journal Abstract Book - October 2020 - 194
Tumori Journal Abstract Book - October 2020 - 195
Tumori Journal Abstract Book - October 2020 - 196
Tumori Journal Abstract Book - October 2020 - 197
Tumori Journal Abstract Book - October 2020 - 198
Tumori Journal Abstract Book - October 2020 - 199
Tumori Journal Abstract Book - October 2020 - 200
Tumori Journal Abstract Book - October 2020 - 201
Tumori Journal Abstract Book - October 2020 - 202
Tumori Journal Abstract Book - October 2020 - 203
Tumori Journal Abstract Book - October 2020 - 204
Tumori Journal Abstract Book - October 2020 - 205
Tumori Journal Abstract Book - October 2020 - 206
Tumori Journal Abstract Book - October 2020 - 207
Tumori Journal Abstract Book - October 2020 - 208
Tumori Journal Abstract Book - October 2020 - 209
Tumori Journal Abstract Book - October 2020 - 210
Tumori Journal Abstract Book - October 2020 - 211
Tumori Journal Abstract Book - October 2020 - 212
Tumori Journal Abstract Book - October 2020 - 213
Tumori Journal Abstract Book - October 2020 - 214
Tumori Journal Abstract Book - October 2020 - 215
Tumori Journal Abstract Book - October 2020 - 216
Tumori Journal Abstract Book - October 2020 - 217
Tumori Journal Abstract Book - October 2020 - 218
Tumori Journal Abstract Book - October 2020 - 219
Tumori Journal Abstract Book - October 2020 - 220
Tumori Journal Abstract Book - October 2020 - 221
Tumori Journal Abstract Book - October 2020 - 222
Tumori Journal Abstract Book - October 2020 - 223
Tumori Journal Abstract Book - October 2020 - 224
Tumori Journal Abstract Book - October 2020 - 225
Tumori Journal Abstract Book - October 2020 - 226
Tumori Journal Abstract Book - October 2020 - 227
Tumori Journal Abstract Book - October 2020 - 228
Tumori Journal Abstract Book - October 2020 - 229
Tumori Journal Abstract Book - October 2020 - 230
Tumori Journal Abstract Book - October 2020 - 231
Tumori Journal Abstract Book - October 2020 - 232
Tumori Journal Abstract Book - October 2020 - 233
Tumori Journal Abstract Book - October 2020 - 234
Tumori Journal Abstract Book - October 2020 - 235
Tumori Journal Abstract Book - October 2020 - Cover3
Tumori Journal Abstract Book - October 2020 - Cover4
https://www.nxtbookmedia.com