Tumori Journal Abstract Book - October 2020 - 31

B - Gastrointestinal (Colorectal) Cancers	
compare tx activity and efficacy according to tumor site.
Primary endpoint was PFS; secondary endpoints were OS
and RR. PFS and OS analyses were performed using
Kaplan-Meier method, and survival curves were compared
using the log-rank test. RR was evaluated according to
RECIST criteria and it was compared in the two groups
using Fisher's exact test. Statistical significance was set at
p = 0.05 for a bilateral test. Univariate and multivariate
analyses for PFS and OS were performed.
Results: A total of 76 RAS/BRAF wt mCRC pts, treated
with third-line anti-EGFR-based tx or R/T, were enrolled.

31
Of those, 19 (25%) pts had R-sided tumor (9 pts received
anti-EGFR tx and 10 pts received R/T) and 57 (75%) pts
had L-sided tumor (30 pts received anti-EGFR tx and 27
pts received R/T). As shown in the table, a significant PFS
and OS benefit in favor of anti-EGFR tx vs R/T was
observed in L-sided pts, while no difference both in PFS
and OS was observed in R-sided pts. RR was significantly
higher in L-sided pts treated with anti-EGFR vs R/T, no
difference was shown in R-sided pts. At the multivariate
analysis, tx regimen was independently associated with
PFS in L-sided pts, but not in R-sided pts.

R-sided

L-sided

 

Anti-EGFR (N=9)

Median PFS (months)

3.5
3.8
HR=1.4 (95%CI 0.53-3.75), p=0.49
9.3
9.2
HR=0.83 (95%CI 0.30-2.26), p=0.696
11%
10%
p=0.99

Median OS (months)
RR
 

Conclusions: Our study confirmed the results deriving
from the retrospective analysis of the phase III study
20020408. Our results demonstrated a different benefit
from third-line anti-EGFR tx according to primary tumor
site, confirming the role of L-sided tumor in predicting
benefit from third-line anti-EGFR vs R/T, while no difference was observed in R-sided tumors.

B06
Tumor mutational load,
microsatellite instability,
BRCAness and actionable
alterations in metastatic
colorectal cancer: Results from
the TRIBE2 study
Rossini D.1, Antoniotti C.1, Marmorino F.1, Lonardi S.2, Corti F.3,
Moretto R.4, Ugolini C.5, Latiano T.P.6, Giordano M.7, Tamburini E.8,
Passardi A.9, Santini D.10, Zaniboni A.11, Aprile G.12, Bordonaro R.13,
Fontanini G.7, Lenz H.14, Falcone A.1, Korn M.15, Cremolini C.1
1
Department of Translational Research and New Technologies in Medicine
and Surgery, University of Pisa, Pisa; 2Medical Oncology Unit 1, Department
of Clinical and Experimental Oncology, Istituto Oncologico Veneto (IOV)
- IRCCS, Padua; 3Fondazione IRCCS Istituto Nazionale Tumori, Milano;
4
Department of Oncology, University Hospital of Pisa, Pisa; 5Unit of
Pathological Anatomy, Azienda Ospedaliero-Universitaria Pisana, Pisa;
6
Division of Medical Oncology, Fondazione IRCCS "Casa Sollievo della
Sofferenza",, San Giovanni Rotondo (FG); 7Department of Surgical, Medical,
Molecular Pathology and Critical Area, University of Pisa, Pisa; 8Oncology
Unit, Ospedale degli Infermi, Rimini; 9Department of Medical Oncology,
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
IRCCS, Meldola (Forlì-Cesena); 10Department of Medical Oncology, University

R/T (N=10)

Anti-EGFR (N=30)

R/T (N=27)

7.3
3.6
HR=0.47 (95%CI 0.26-0.85), p=0.0028
15.2
11.0
HR=0.58 (95%CI 0.31-1.08), p=0.0428
43%
0%
p<0.0001

Campus Biomedico, Roma; 11Medical Oncology Unit, Poliambulanza
Foundation, Brescia; 12Department of Oncology, University and General
Hospital, Udine; 13Medical Oncology Unit, ARNAS Garibaldi, Catania;
14
University of Southern California, Los Angeles (California); 15Caris Life
Sciences, Phoenix (Arizona)

Background: We performed a comprehensive NGS analysis of samples from randomized mCRC patients in TRIBE-2
trial in order to investigate the prognostic impact of tumor
mutational load (TML), its additional value with respect to
the assessment of microsatellite instability (MSI), and the
overall prevalence of potentially actionable alterations. We
also investigated the prevalence and the prognostic impact
of the so-called "BRCAness" alterations.
Methods: Tumor DNA was obtained from formalin-fixed,
paraffin-embedded blocks from primary tumors of 296
(44%) of 679 randomized patients, and underwent NGS
analysis using the Caris MI TumorSeek panel, assessing
592 genes. TML was defined as low, intermediate, or high
based on finding <7, 7-16, or >16 mutations/Mb. MSI
status was determined both by NGS and by IHC.
BRCAness group was defined by the presence of pathogenic alterations in at least one of the following genes:
BRCA1/2, PALB2, RAD50, RAD51, ATM, ATR,
FANC(A-C- D2-E-F-G-L), EMSY, BARD1, BRIP1,
CHEK1, CHEK2, MRE11, BLM, NBN, or WNR.
Results: TML and MSI were determined by NGS in 224
(76%) cases. NGS and IHC results were concordant in 221
(99%) cases. TML was low, intermediate, or high in 56
(25%), 157 (70%), and 11 (5%) cases, respectively. TMLhigh tumors were MSI-high or MSS in 8 (73%) and 3
(27%) cases, respectively. Two of 3 TML-high and MSS



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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Tumori Journal Abstract Book - October 2020 - Cover3
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