Tumori Journal Abstract Book - October 2020 - 30

30	
(N=237), 14 (6%) pts had r-s tumor and 223 (94%) l-s
tumor. No significant association of tumor sidedness with
survival was shown (DFS r=10.0 vs l=16.0 month, p=0.62;
OS r=40.3 vs l=66.2 months, p=0.12).
Conclusions: Our results showed that a significant smaller
proportion of r-s CRC underwent to radical LM rection,
indirectly confirming its worse prognosis. Among radically
resected pts, r-s CRC was associated to a shorter OS (significant) and DFS (not significant) compared to l-s CRC,
but it was not confirmed at the multivariate analysis. We
can conclude that right PT site should not be considered as
a contraindication for radical LM surgery, when feasible.

B04
Monocyte-to-lymphocyte ratio to
better define survival outcomes
and metastatic spread in stage III
colon cancer
Buriolla S.1, Basile D.1, Polano M.2, Gallois C.3, Corvaja C.4, Andreotti
V.J.4, Parnofiello A.1, De Scordilli M.1, Michelotti A.1, Ongaro E.5,
Cinausero M.6, Foltran L.5, Toffoli G.2, Pella N.7, Buonadonna A.5,
Zaanan A.3, Fasola G.7, Aprile G.8, Taieb J.3, Puglisi F.1
1
Department of medical oncology and cancer prevention, IRCCS National
Cancer Institute, Aviano (IT); Department of Medicine (DAME), University of
Udine, Udine (IT) - Aviano, Aviano; 2Experimental and Clinical Pharmacology
Unit, IRCCS National Cancer Institute, Aviano (IT); Aviano; 3Hôpital Européen
Georges-Pompidou, Paris; 4Department of Oncology, ASUIUD Santa Maria
della Misericordia, Udine, (IT); Department of Medicine (DAME), University
of Udine, Udine - Udine, Udine; 5Department of medical oncology and
cancer prevention, IRCCS National Cancer Institute, Aviano (IT);, Aviano;
6
Department of Oncology, ASUIUD Santa Maria della Misericordia,
Udine, (IT);, Udine; 7Department of Oncology, ASUIUD Santa Maria della
Misericordia, Udine, (IT) - Udine, Udine; 8Department of Oncology, San
Bortolo General Hospital, Vicenza, Vicenza

Background: Circulating monocytes are recruited in the
tumor site to differentiate into tumor-associated macrophages, acquiring pro-tumor functions and suppressing
adaptive immune response. This study aims at investigating a prognostic tool based on lymphocytes ratio (LR) to
better classify stage III colon cancer (CC) patients (pts).
Material and Methods: This is a multicentric study conducted on 653 consecutive CC pts treated between 20082019 at the Centres of Aviano, Pordenone, Udine and Paris
(HEGP). A Cox regression model was used to determine
the prognostic impact in terms of overall survival (OS) and
disease-free survival (DFS). The performance of the prognostic model was evaluated using the Harrell's C statistic
(HCS). Random Forrest (RF) to predict pattern of metastasis was implemented on python using h2oai.
Results: Overall, 70% had stage IIIB, 75% G1-2 tumors
and 57% CEA>5. Notably, 50%, 41% and 14% had a lymphatic (LI), vascular (VI) and perinervouse infiltration
(PI), respectively. Regarding the molecular profile, 45/263
pts had MSI status, 94/212 and 28/199 were KRAS and

Tumori Journal 106(2S)
BRAF mutated. At median follow-up of 59 mo, median
DFS and OS were not reached, 32% of pts relapsed and
24% died. At 3y-DFS 24% relapsed. By multivariate analysis, including potential confounders, significantly shorter
DFS (HR 1.84, 95%CI 1.13-3.00, p=0.014) and OS (HR
2.32, 95%CI 1.27-4.25) were observed among high monocyte-to-LR (MLR >0.45) patients compared to low. MLR
was associated also with 3y-DFS (p=0.02). The addition of
MLR improved the performance of the prognostic model
(from 0.69 to 0.87 HCS). RF showed that BRAF, LR, sidedness, KRAS, CEA, and LDH were the main features
linked with liver (ACC 0.67) and node (0.68)
organotropism. LDH, PI, LR, KRAS, pT, pN with lung
(0.77), while LR, sidedness, KRAS, BRAF, MMR and VI
with bone (ACC 0.55). Factors linked with peritoneum
were LR, CEA, BRAF, pT, pN (ACC 0.57).
Conclusions: A prognostic model including MLR results
more accurate in predicting survival and metastatic process in stage III CC, allowing a more tailored monitoring.
These findings pave the way at developing a potential
nomogram based on MLR and macrophages immunescore to more accurately define stage III CC.

B05
Efficacy of third-line anti-EGFRbased treatment (tx) versus
(vs) Regorafenib/TAS-102 (R/T)
according to primary tumor
site in RAS/BRAF wild-type (wt)
metastatic colorectal cancer
(mCRC) patients (pts)
Vivolo R.1, Bria E.1, Zurlo I.V.2, Bensi M.1, Dell'Aquila E.3, Anghelone
A.1, Corsi D.C.4, Caira G.5, Santini D.3, Ingrosso D.6, Emiliani A.4,
Calegari M.A.1, Citarella F.3, Pozzo C.1, Grande R.7, Basso M.1,
Tortora G.1, Salvatore L.1
1
Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico
Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore,
Roma; 2Università cattolica del Sacro Cuore-Oncologia Medica San Giovanni
Calibita, Fatebenefratelli, Roma; 3Oncologia Medica, Policlinico Universitario
Campus Bio-Medico, Roma; 4Oncologia Medica San Giovanni Calibita,
Fatebenefratelli, Roma; 5Università Cattolica del Sacro Cuore, Roma; 6
Università Cattolica del Sacro Cuore, Roma; 7Oncologia Medica, Ospedale
Fabrizio Spaziani, Frosinone

Background: Right (R) and left-sided (L) mCRCs exhibit
different clinical and molecular features. Several retrospective analyses showed that the survival benefit of antiEGFR-based tx is limited to RAS/BRAF wt L-sided mCRC
pts, which a larger effect in the first-line setting. Few data
are available concerning the anti-EGFR efficacy according
to primary tumor site in third line.
Methods: Pts affected by RAS/BRAF wt mCRC treated
with third-line anti-EGFR-based tx or R/T were retrospectively collected. The objective of the analysis was to



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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