Tumori Journal Abstract Book - October 2020 - 3

A - Thoracic Cancers	

3

17% of PTS, in 28% was delayed and in 5% was permanently discontinued. Grade 3 ocular toxicity occurred in
11% of patients, no grade 4 ocular toxicity was reported;
no death was considered drug-related.
Conclusions: We report the first "real world" experience
of Depatux-M plus TMZ in recurrent GBM. We showed
encouraging clinical benefit, despite most patients were
treated beyond the second-line of therapy. Overall, the
results are closed to those reported in previous phase II
trial. Toxicity was moderate and manageable. This combination would be re-considered as a potential treatment for
this setting of patients.

03*
Maintenance versus
discontinuation of androgen
deprivation therapy during
docetaxel administration with
a continuous or an intermittent
schedule in metastatic,
castration resistant, prostate
cancer patients. A multicenter
randomized phase III study of the
Piemonte Oncology Network
1

2

2

3

with suspension of LHRH-A (DL-). Pts with progressionfree disease after 4 D cycles underwent second randomization to receive continuous (35 pts) vs intermittent (42 pts)
D therapy.ADT in the DL- arm was restored upon D discontinuation due to disease progression.
Results: PSA response was observed in 43.8% and 38.2%
of DL+ and DL- pts. Median progression free survival
(PFS) was 10.3 months in DL+ and 10.8 months in DLpts (Hazard Ratio [HR] 1.02, 95% confidence interval
(CI): 0.76-1.36, p=0.9), the corresponding median overall
survival (OS) was 23.3 and 24.8 months, respectively
(HR 1.02, 95% CI: 0.75-1.38, p=0.91). Toxicity did not
differ in the 2 treatment arms. After six months of therapy,
serum testosterone levels raised above the castration
range in 23 (22.8%) DL- pts, while in 6 (5.9%) DL- pts
testosterone attained normal levels. No difference in terms
of PSA response, PFS and OS was observed comparing
pts randomized to continuous versus intermittent D
administration.
Conclusions: The efficacy of docetaxel in mCRPC pts is
not influenced by the maintenance or suspension of ADT
nor by the continuous or intermittent schedule of administration. Quality of life data will be available at the meeting.

A - Thoracic Cancers
4

Bianchi S. , Alessandra M. , Prati V. , Ortega C. , Buttigliero C. , Fea
E.5, Vanella P.5, Valcamonico F.6, Ciccone G.7, Sirotova Z.8, Chiappino
I.9, Dal Canton O.10, Masini C.11, Sacco† C.12, Amoroso D.13, Leone
F.14, Comandone A.15, Gennari A.16, Berruti A.6, Tucci M.17
1

ASST Spedali Civili di Brescia - Università degli studi di Brescia, Brescia;
Candiolo Cancer Institute, FPO-IRCCS, Candiolo; 3ASL CN2, Alba; 4A.O.U.
San Luigi Gonzaga, Orbassano; 5A.O.S.Croce e Carle, Cuneo; 6ASST Spedali
Civili di Brescia - Università di Brescia, Brescia; 7CPO Piemonte, Torino;
8
Azienda USL della Valle d'Aosta, Aosta; 9AOU Città della Salute e della
Scienza di Torino, Torino; 10ASL TO4, Ciriè, Chivasso, Ivrea; 11AUSL-IRCCS
di Reggio Emilia, Reggio Emilia; 12Azienda Sanitaria Universitaria Integrata,
Udine; 13Azienda USL 12, Viareggio; 14ASL Biella, Biella; 15San Giovanni
Bosco, Torino; 16Ospedale Maggiore della Carità, Novara; 17ASL AT, Asti
2

Background: The maintenance of androgen deprivation
therapy (ADT) is the current standard of care in metastatic castration resistant prostate cancer (mCRPC)
patients (pts) eligible to docetaxel (D). However, no randomized clinical trials have been conducted to support its
efficacy. Furthermore, limited data are available on headto-head comparison of intermittent versus continuous D
schedule.
Methods: In this multicenter, open-label, phase 3 randomized trial, 198 pts were enrolled between 2010 and
2014. The study was early interrupted due to insufficient
accrual. In the first randomization, 96 pts received D 75
mg/m2 every 3 weeks with maintenance of LHRH-A
(DL+), while 102 pts received D 75 mg/m2 every 3 weeks

A01*
Selpercatinib (LOXO-292) in patients
with RET-fusion+ non-small-cell
lung cancer
Goto K.1, Oxnard G.R.2, Tan D.S.3, Loong H.H.4, Bauer T.M.5, Gainor
J.F.6, McCoach C.E.7, Gautschi O.8, Besse B.9, Cho B.C.10, Peled N.11,
Weiss J.12, Kim Y.13, Ohe Y.14, Horiike A.15, Park K.16, Huang X.17,
Olek E.17, Subbiah V.18, Drilon A.E.19, Cappuzzo F.O.20
1
National Cancer Center Hospital East, Kashiwa; 2Dana-Farber Cancer
Institute, Boston; 3National Cancer Centre Singapore, Singapore; 4The
Chinese University of Hong Kong, Shatin; 5Sarah Cannon Research
Institute, Nashville; 6Massachusetts General Hospital Cancer Center,
Boston; 7University of California, San Francisco; 8University of Berne
and Cantonal Hospital of Lucerne, Lucerne; 9Gustave Roussy Université
Paris Sud, Villejuif; 10Yonsei Cancer Center, Yonsei University College of
Medicine, Seoul; 11Soroka Medical Center, Beer Sheva; 12University of
North Carolina, Chapel Hill; 13Seoul National University Bundang Hospital,
Gyeonggido; 14National Cancer Center Hospital, Tokyo; 15The Cancer
Institute Hospital of Japanese Foundation for Cancer Research, Tokyo;
16
Samsung Medical Center, Sungkyunkwan University School of Medicine,
Seoul; 17Loxo Oncology Inc., a wholly owned subsidiary of Eli Lilly and
Company, Stamford; 18MD Anderson Cancer Center, Houston; 19Memorial
Sloan Kettering Cancer Center, New York; 20Hematology and Oncology
Department, AUSL della Romagna, Ravenna

Background: Selpercatinib (LOXO-292) is a highly selective and potent small molecule RET kinase inhibitor. Here
we report an update on the efficacy and safety of



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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