Tumori Journal Abstract Book - October 2020 - 28

28	
Conclusions: In this case series, GI toxicity presented as
reported in literature. We found of interest, even if in a
very small group, the apparent correlation between GI
toxicity and prolonged clinical benefit of IT. GI toxicity
seems to be a "marker" of immune system activation.
Pathophysiology of toxicity and its possible relationship
with outcome should be studied in larger population.

B - Gastrointestinal (Colorectal)
Cancers
B01*
ADJUVANT THERAPY IN STAGE III AND
ELDERLY PATIENTS WITH COLON
CANCER: SUBGROUP ANALYSIS OF THE
TOSCA TRIAL
Rosati G.1, Galli F.2, Carlomagno C.3, Bidoli P.4, Amoroso D.5,
Bochicchio A.M.6, Ciarlo A.7, Maiello E.8, Frassineti L.9, Corsi
D.10, Buonadonna A.11, Turci D.12, Cortesi E.13, Zaniboni A.14,
Marchetti P.15, Rebuzzi S.E.16, Galli F.2, Silvestri N.17, Bernardini
I.18, Labianca R.19
1

Ospedale San Carlo, Potenza; 2Istituto di Ricerche Farmacologiche
Mario Negri IRCCS, Milano; 3Università degli studi Federico II, Napoli;
4
Azienda Ospedaliera S. Gerardo, Monza; 5Ospedale Versilia, Lido di
Camaiore; 6Ospedale Oncologico Regionale CROB, Rionero in Vulture;
7
Azienda USL4, Prato; 8Casa Sollievo della Sofferenza, San Giovanni
Rotondo; 9Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori,
Meldola; 10Ospedale S. Giovanni Calibita Fatebenefratelli, Roma; 11Centro
Riferimento Oncologico, Aviano; 12Ospedale Santa Maria delle Croci,
Ravenna; 13Policlinico Umberto I, Roma; 14Fondazione Poliambulanza Istituto
Ospedaliero, Brescia; 15Ospedale IDI IRCCS, Roma; 16IRCCS Ospedale
Policlinico San Martino, Genova; 17IRCCS Istituto Tumori "Giovanni Paolo II",
Bari; 18Ospedale Ramazzini, Carpi; 19Cancer Center ASST Papa Giovanni
XXIII, Bergamo

Background: Previous studies stating the oxaliplatinbased chemotherapy as the standard of care for the adjuvant therapy of stage III colon cancer (CC) patients (pts)
obtained controversial results and a reduced benefit for
those over the age of 70 years.
Methods: Our group assessed the impact of age (categorized as < or > 70 years) on relapse free interval (RFI),
defined as time from random to relapse or last disease
assessment, in stage III CC pts randomized to receive 3 or
6 months of FOLFOX (fluorouracil, leucovorin plus oxaliplatin) or CAPOX (capecitabine plus oxaliplatin) in the
Italian, multicenter, phase III, TOSCA study (clinicaltrials.
gov NCT0064660).
Results: 3,759 pts were enrolled from 130 sites. Overall,
2,360 of them had stage III disease, including 1,667 aged
under 70 and 693 aged 70 or over. The elderly had an
ECOG performance status (PS) more often equal to 1
(10.5% vs 3.3%, p <0.001), fewer women (40.8% vs
45.1, p=0.057), more T3/T4 tumors (90.9% vs 84.3%,
p<0.001), a greater number of poorly differentiated (G3)

Tumori Journal 106(2S)
tumors (28.3% vs 24.2%, p=0.039) and located on the
right (40.9% vs 26.6%, p <0.001). No variation for type
and treatment arm (p=0.965) was observed. The median
follow-up was 62.5 and 60.6 months for the under 70 and
the over 70, respectively. In pts over 70, we found a
greater proportion of dose reductions (46.7% vs 41.4%,
p=0.018), treatment interruptions (26.1% vs 19.3%,
p<0.001) and a higher proportion of recurrences (24.2%
vs 20.3%, p=0.033). The multivariable analysis of the
RFI, corrected for sex, ECOG PS, tumor site, stage, grade,
treatment, treatment duration and dose reduction, does not
indicate a statistically significant effect of age (HR 1.19,
95% CI 0.98-1.44, p=0.082), although the point estimate
is not negligible. Only a stage III high risk CC had a significant impact on RFI (HR [vs low risk] 2.05, 95% CI
1.71-2.46, p<0.001).
Conclusions: Comparing to younger pts, in elderly stage
III CC pts treated with an oxaliplatin-based adjuvant therapy, a different treatment tolerability and a potential reduction of benefit was highlighted. Considerations should be
made about the patient's general health status, his comorbidities and the management of the expected side effects.
Disease free survival and overall survival data will be provided at the meeting.

B02*
Consensus Molecular Subtypes
and CRCAssigner classifications
in metastatic colorectal cancer
(mCRC): prognostic and predictive
impact in the TRIBE2 study
Borelli B.1, Fontana E.2, Giordano M.3, Antoniotti C.1, Bergamo F.4,
Murgioni S.4, Pietrantonio F.5, Morano F.5, Tamburini E.6, Boccaccino
A.1, Santini D.7, Conca V.1, Pella N.8, Maiello E.9, Ugolini C.10,
Fontanini G.3, Falcone A.1, Nyamundanda G.2, Sadanandam A.2,
Cremolini C.1
1

Department of Translational Research and New Technologies in Medicine
and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria
Pisana, Pisa; 2Division of Molecular Pathology, The Institute of Cancer
Research, London; 3Department of Surgical, Medical, Molecular Pathology
and Critical Area, University of Pisa, Pisa; 4Unit of Medical Oncology
1, Department of Oncology, Istituto Oncologico Veneto, IRCCS, Padua;
5
Medical Oncology Department, Fondazione IRCCS Istituto Nazionale
dei Tumori di Milano, Milan; 6Oncology Unit, Ospedale degli Infermi,
Rimini; 7Department of Medical Oncology, University Campus Biomedico,
Rome; 8Department of Oncology, University and General Hospital, Udine;
9
Oncology Unit, Foundation IRCCS Casa Sollievo della Sofferenza, San
Giovanni Rotondo; 10Unit of Pathological Anatomy, Azienda OspedalieroUniversitaria Pisana, Pisa

Background: The TRIBE2 study (NCT02339116) recently
demonstrated the superiority of upfront FOLFOXIRI plus
bevacizumab (bev) when compared to a pre-planned strategy
of doublets plus bev in molecularly unselected but mostly
(74%) RAS/BRAF mutant mCRC patients. The Consensus



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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