Tumori Journal Abstract Book - October 2020 - 26

26	
-0.2370-0.6472; p = 0.0304). At multivariate analysis
CRP was an independent predictive factor of clinical
response (p = 0.0213), PFS (p = 0.0006) and OS (p =
0.0027). The miniCASCO correlated positively with PS (r
= 0.567; p = 0.036) and negatively with CR (r = -0.438;
p = 0.010). Moreover, patients with partial response and
stable disease had a significant decrease of CRP and a significant increase of MMI and hemoglobin compared to pts
with progressive disease.
Conclusions: Our results showed, even in a limited sample size, the negative correlation of inflammation and poor
nutritional status with clinical response and survival in
NSCLC pts treated with immunotherapy. Blocking inflammation and the related nutritional impairment may be crucial in improving efficacy of immunotherapy in advanced
lung cancer pts.

A40

Tumori Journal 106(2S)
were over 70. Immunotherapy related pneumonia occurred
in 7 patients with nonsquamous histology and in 6patients
with squamous histology. Among nonsquamous patients,
four developed pneumonia G1(4/96) (4,3%), two had
pneumonia G2 (2/96) (2,2%) and one pneumonia G3
(1/96) (1,1%). All six squamous patients developed pneumonia G1 (19,4%). In this sample, risk of pneumonia was
increased and statistically significant (p<0,048) for
squamous histology compared with patients with nonsquamous histology.
Conclusions: The risk of pneumonia associated with
Immunotherapy was increased in squamous patients.
However the success of immunotherapy is related to ongoing evaluation/identification and treatment of these immunerelated side effects.

A41

Pneumonia associated with
Immune Checkpoint Inhibitors in
non-small-cell lung cancer

Efficacy and tolerability of
immune checkpoint inhibitors in
NSCLC: our experience of a single
institution

Sorace C.1, Di Lisa F.S.1, Borrelli A.1, Speranza I.2, Bianco V.2,
Cristofani L.1, Arcuri T.1, Fuccillo F.1, Singarj M.1, Gozzi E.1,
Santamaria F.1, Resuli B.1, Vivona L.1, Fusco F.1, Astorino V.1, Rossi
L.3, Verrico M.1, Tomao S.1

Cristofani L.1, Di Lisa F.S.1, Borrelli A.1, Astorino V.1, Sorace C.1,
Fuccillo F.1, Speranza I.2, Bianco V.2, Santamaria F.1, Fusco F.1, Sinjari
M.1, Gozzi E.1, Resuli B.1, Arcuri T.1, Vivona L.1, Rossi L.3, Verrico
M.1, Tomao S.4

1
Università Sapienza, Roma; 2Policlinico Umberto 1, Roma; 3ASL Latina,
Presidio Aprilia, Roma

1
Università Sapienza, Roma; 2Policlinico Umberto I, Roma; 3ASL Latina,
Aprilia; 4Università Sapienza Policlinico Umberto I, Roma

Backgrund: Immunotherapy has transformed cancer
treatment. However, increasing use of immune-based
therapies, including the class of agents known as immune
checkpoint inhibitors, has exposed a discrete group of
immune-related adverse events (irAEs), different from
that related totraditional chemotherapeutic agents and
molecularly target therapies. Skin, gut, endocrine, lung
and musculoskeletal are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic occur much less frequently. In particular lung
toxicity is infrequent but potentially fatal. According to
Common Terminology Criteria for Adverse Events
(CTCAE) lung toxicity is divided in G1 in asymptomatic
patient, G2 in symptomatic patients with drug intervention, G3 in severely symptomatic patients who need oxygen, G4 as risk to life.
Methods: We retrospectively reviewed the records of 126
patients with non-small-cell lung cancer (NSCLC) treated
with Nivolumab and Pembrolizumab at Policlinico
Umberto 1 between 2015-2019. We evaluated the association of immunotherapy toxicity with age, gender and histological types of lung cancer.
Results: We identified 42 women and 84 men; 94 with
non-small-cell lung cancer and 32 with squamous cell cancer. 56% of the patients were under 70 years old and 44%

Background: Immunotherapy is one of the most interesting and innovative treatment strategy in oncology and it
has proven to be potentially effective in several cancers by
showing prolonged disease control in a significant percentage of patients. The main pathway studied is the PD1 /
PDL1 checkpoint which leads to inhibition of the immune
response. Several antibodies are used to contrast this
mechanism, including Nivolumab and Pembrolizumab.
These drugs cause immune-mediated side effects, such as
pneumonia, hepatitis, colitis, thyroiditis.
Methods: The aim of our study was to assess toxicity and
the response to therapy in NSCLC patients treated by
nivolumab and pembrolizumab by dividing them into
groups by age, gender and tumor histotype. We retrospectively analyzed 126 patients treated for NSCLC with
immunotherapy at Sapienza University of Rome during
the period 2015-2019: 103 treated with nivolumab and 23
with pembrolizumab. 84 were men and 42 women with an
average age of 68 years (range 46-86).
Results: At a median follow-up of 12 months 25.4% of the
patients presented a partial or complete response; this
value reaches 41.9% in squamous histology which represented 24.6% of the total patients. About 80% of the total
patients reported adverse events of all grades, most frequent were fatigue, pain and diarrhea; 22% had grade G3-4



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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