Tumori Journal Abstract Book - October 2020 - 24

24	
institution between October 2015 and April 2020. All
patients were candidate for immunotherapy, according to
the tumor molecular profile. Descriptive statistics were
used to analyze patients' baseline features. Tumor response
was evaluated using RECIST version 1.1 guidelines. Uni
and multivariate analysis were conducted to investigate the
relationship between statin use and response to immunotherapy, using the χ2-test. Kaplan-Meier curves were used
to estimate both OS and PFS in statin and non-statin users.
Results: Among all 162 screened patients, 122 met the
requested criteria (52 in the non-statin group, 70 in the statin group) and were included in the final analysis. Median
PFS was 17,57 months in the statin group and 9,57 months
in the non-statin group, with a p=<0.001. Also median OS
was superior in the statin-users group, with a statistically
significant difference (19,94 vs 10,94 months, p=<0.001).
Conclusions: In our study, we demonstrated a significant
relationship between improved PFS and OS and statin use
when compared to those achieved in non-statin users.
Although interesting, this result needs to be validated with
randomized clinical trials and larger cohorts.

A36
Is a systemic treatment for
metastatic lung cancer in
patients with diagnosis of
Idiopathic Pulmonary Fibrosis
detrimental?
Della Torre S.1, Zannier F.2, Di Bella S.2, Cozzi C.2, Bollina R.2
1

ASST-Rhodense- U.O. di Oncologia Medica, Rho, Milano; 2ASST-RhodenseUO di Oncologia Medica, Rho, Milano

Background: Despite Lung Cancer (LC) is often associated with Idiopathic Pulmonary Fibrosis (IPF), it is still
debated if it is useful to treat patients with metastatic disease with systemic chemotherapy. We present 3 similar
cases of Lung Adenocarcinoma and their outcome during
systemic treatment for metastatic disease.
Patients and methods: Among 75 pts with metastatic
Lung Cancer treated in our hospital in 2018 and 2019, 3
pts had diagnosis of IPF other than metastatic Lung
Adenocarcinoma. They developed metastatic disease during follow-up after surgery approach for primary tumors.
Results: All patients were male, median age 69yrs, with
smoke history (median 20.2 pack-years). Low disease burden and asymptomatic metastatic lesions characterized all
cases. The disease's sites were not bulky mediastinic
nodes, oligo-metastases in bone and lung. Because of
EGFR, ALK and PDL-1 negativity, they were candidated
to systemic first line chemotherapy with CDDP and
Pemetrexed. During systemic therapy all patients experienced a respiratory failure for IPF's worsening in two
cases and for lung complications and cancer progression in

Tumori Journal 106(2S)
the other one, with hospital admissions. The treatment was
stopped respectively after 5, 4 and 6 cycles and median
survival was 6 months.
Conclusions: Our cases confirm the systemic chemotherapy might induce the IPF's worsening and increase the risk
of pulmonary adverse events. The poor survival is similar
to that reported in previously studies. Above all in oligometastatic and asymptomatic disease the choice to not treat
with chemotherapy pts with metastatic lung cancer and
IPF should be considered.

A37
Body composition and
inflammatory status impact
in non-small cell lung cancer
patients treated by first line
immunotherapy. A monocentric
experience
Baldessari C.1, Guaitoli G.1, Valoriani F.1, Bonacini R.1, Marcheselli
R.1, Linda R.1, Pecchi A.1, Menozzi R.1, Torricelli P.1, Bertolini F.1,
Dominici M.1, Barbieri F.1
1

University Hospital of Modena, Modena

Background: Immunotherapy (IT) changed the landscape
of NSCLC. Several efforts were made to understand and
implement its action. Body composition and balance of
nutrition and inflammatory status are important factors for
immune system function and IT effectiveness. This study
aims to evaluate the correlation of muscle mass (MM) and
adipose tissue (AT) parameters, BMI, weight loss (WL),
blood exams (BE) and nutritional and inflammatory scores
with outcome, response and toxicities in NSCLC patients
(pts) treated by first line IT.
Patients and methods: We analysed 44 consecutively pts
who received at least two doses of pembrolizumab between
07.2017 and 12.2018. MM and AT were studied from L3
sections in CT scans routinely performed. Kaplan-Meier
method was used to calculate survival curves, log-rank test
to compare groups based on literature cut-off or normal
values, Cox proportional hazard model for uni and multivariate analysis and Fisher exact test to examine differences between categorical variables.
Results: mOS was 9.2 months (mo) (95% CI 6.1-24.2),
mPFS 6 mo (95% CI 4-11.5) and overall response rate
56%. 50% of pts experienced G1-2 toxicities, 10% G3-4.
Sex, age, smoking status, baseline CNS metastases, BMI,
WL, MM and AT parameters, C-reactive protein, NLR
and PLR were not significantly related with OS, although
sometimes a trend was seen. Pts with higher MM or muscle density have a trend for better OS. Better OS was confirmed by ECOG 0-1 (p=0.032), normal WBC (p= 0.023),
normal albumin (p=0.03) and low Prognostic Index
(p=0.008), a trend was showed for Advance lung cancer



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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