Tumori Journal Abstract Book - October 2020 - 214

214	

Tumori Journal 106(2S)

Schipilliti F.M.1, Trudu L.1, Napolitano M.1, Martelli F.1,
Prampolini F.1, Pecchi A.R.1, Valoriani F.1, Reverberi L.1,
Spallanzani A.1, Depenni R.1, Massimo D.1, Bertolini F.1

sarcopenia may be a simple and suitable tool to predict
response to immunotherapy of SCCHN.

1

Azienda Ospedaliera Universitaria di Modena e Reggio Emilia, Modena

Background: Sarcopenia is an emerging problem in cancer patients (pts), significantly important in SCCHN pts.
Aim of this study is to analyze the impact of sarcopenia on
efficacy of Nivolumab in RM-SCCHN cancer pts after
platinum failure.

Methods: Clinical and radiological data of 24
RM-SCCHN pts undergoing Nivolumab at Modena
University Hospital from 2016 to 2019 were retrospectively reviewed. Sarcopenia was assessed using abdominal computed tomography scan (CT) before Nivolumab
starting and after 8-12 weeks of therapy. Skeletal
Muscle Mass (SMI cm2/m2) at L3 levels, Subcutaneous
Fat Index (SFI cm2/m2), Visceral Fat Index (VFI cm2/
m2) were considered for the analysis; variables were
correlated with survival (short vs long survivors, SS vs
LS, considering mOS <6month vs ≥ 6mo) and disease
control (responders, R, considered as OR + SD vs nonresponders, nR). In a subgroup of pts, the variation of
SMI between the first and the second CT was described
and correlated with survival and response.
Results: 20 pts were evaluable for analysis: 15 (75%) were
male; median age: 61 y-o (52-77), most of them had oropharynx (7, 35%) or oral cavity cancers (5, 25%) as primary
sites; 13 pts (65%) had a normal BMI before starting
Nivolumab. Median OS was 3 mo (0-11): 13 pts (65%) were
SS, 7 (35%) LS; R vs nR were 13 (65%) and 7 (35%),
respectively. At univariate analysis, no correlation between
baseline SMI, SFI, VFI and survival was observed. On the
contrary, we found a correlation between mean baseline values of SMI, SFI, VFI and response, in particular for SMI
55,4 in R vs 42,82 in nR, p=0,0008; SFI 61,79 in R vs 38,59
in nR, p=0,0009; for VFI 65,33 in R vs 44,77 in nR,
p=0,0431. If we consider 15 pts evaluable for both CTs, 11
pts (73%) had a reduction of SMI at the second CT: mOS
was 4 mo (2-9), 7 pts (64%) were SS and 7 pts (64%) were
nR. Oppositely, 4 pts (27%) had an increase of SMI: mOS
was 10 mo (0-11), 3 pts (75%) were LS and 2 (50%) were R.
Conclusions: Sarcopenia is a widespread, but underestimated problem of SCCHN; it may be simply assessed
using CT, employed in clinical practice for disease evaluation. Detection of body composition and identification of

ULBA06
Prospective validation study
on the degree of difficulty of
Huber needle insertion in totally
implanted CVADs.
Civetta G.1, Lombardi L.1, Lanotte A.1, Delvecchio A.M.1, Colonnata
M.1, Todisco A.1, Cristallo R.1, Marcone A.1, Somma M.1, Vitale E.2,
Gadaleta Caldarola G.1
1
Dipartimento di Oncoematologia-U.O.C. Oncologia Medica, P.O."Dimiccoli"
di Barletta -ASL BT- , Barletta (BT); 2Dipartimento di Scienze Mediche
di Base, Neuroscienze e Organi di Senso. Università degli Studi di Bari
"A.Moro", Bari

Background: The safeguarding of venous assessment in
cancer patients involves the placement of vascular devices.
In those totally implantable, such as, thoracic and brachial
port-a-cath, it requires the introduction of the Huber needle
to infuse liquids or take blood samples. The purpose of the
study is to validate a prognostic index that weighs the difficulty of inserting the needle by NIDS (Needle Inserting
Difficulty Scale) implementation, using SPIA (Subcutaneous
Port-a-cath Investigator Assessment), to improve the quality
of the nursing procedure offered to the patient. 
Materials (Patients) and Methods: SPIA defines brachial and thoracic implants into three different groups:
Type 1: port visible to the naked eye, well palpable and
immobile; Type 2: port not visible to the naked eye, palpable and not very mobile; Type 3: port not visible to the
naked eye, hardly palpable, mobile or elusive. Subsequently
a questionnaire containing 5 questions was administered to
each patient to define the NIDS, specifically: in number of
years of use of the CVAD, if over time there have been
events of unsuccessful needle insertion, if it has been contacted a specialist/expert nurse, if you have experienced an
increase or decrease in your body weight since implantation. The answers to each question were associated with
the type of CVAD implantation (SPIA), defined by investigator nurse.
Results: 175 patients were included in the study and identified a low degree of difficulty for thoracic types 1 and 2
and brachial type 1. A high degree of difficulty for thoracic

Table 1.  The SPIA different types and NIDS Algorithm
Puncture

NIDS

Port-a-cath

Single

Multiple

Generalist nurse

Specialist nurse

Brachial

Type 1
Type 1 / 2

Type 2 / 3
Type 3

Type 1
Type 1 / 2

Type 2 / 3
Type 3

Thoracic



Tumori Journal Abstract Book - October 2020

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Contents
Tumori Journal Abstract Book - October 2020 - Cover1
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Tumori Journal Abstract Book - October 2020 - I
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Tumori Journal Abstract Book - October 2020 - Contents
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Tumori Journal Abstract Book - October 2020 - Cover3
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