Tumori Journal Abstract Book - October 2020 - 213

Late Breaking Abstracts	
training (40-70% of the heart rate reserve; 20 to 60 min
3-day/week); control arm with usual care recommendations. Patients enrolled in January 2020 were monitored
for diet habits by DianaWeb platform, they carried out the
exercise training across the COVID-19 pandemic shifting
from the gym to a home-based exercise program. The
objective was to investigate the effects of lifestyle program
on quality of life by EORTC QLQ-C30 and health-related
QoL parameters such as cardiac function indexes; heart
rate variability (HRV) (by repeated Holter 24h) and cardiorespiratory fitness by estimated maximal oxygen uptake
(VO2max). 
Results: There were no adverse events and a high attendance was registered considering the challenges to be overcome in shifting to a home-based exercise program.
Statistical analysis revealed a significant improvement in
both arms in QLQ scale score: in global health status (from
64.7±17 to 15.9±13; coefficient of variation (CV) 15.9%;
p=0.0015); physical functioning (from 54.4±12.3 to 6±6.6;
CV 13.9%; p=0.0005); fatigue (from 26.3±23.4 to
11.9±14.3; CV -54.9%; p=0.0008) and showed a general
improvement over time even on the social functioning
(from 47.2 ± 22.8 to 66.7±00; CV 41.2%; p=0.0001). Both
groups had a significant improvement in HRV parameters
in both time and frequency domain: average SDNN/5min
and VLF increased (from 50.6±14.4 to 55.2±16.7msec,
p=0.033 and form 1597±967 to 1881±963 msec, p=0.04,
respectively); mean heart rate decreased (from 76.6 ±7.8 to
73.7±8.3 bpm after training, p=0.009) and both arms
improved the cardiorespiratory fitness level (VO2max from
30.7±5.7 to 33.9±6.64 mL/kg/min; CV 10.3%; p<0.001). 
Conclusions: Despite the challenges faced during the pandemic, a change in lifestyle integrating exercises, nutrition
and educational counseling provides benefit to BC patients
when delivered in a clinic-based setting group including
the exercise specialists.

ELBA04
Advanced Breast Cancer
at presentation (ABC-p)
in Octogenarians
Women(OW):specific elderlydevoted risk tests(SEDRT)
(CARG+CRASH) as new tools to
prevent serious/irreversible
adverse reactions(AR) in frail
patients

213
Due to current lengthening of average lifespan and progressive increase of malignant tumors in mankind, more
new strategies must be constantly sought especially for
third-age neoplasms. Nevertheless because severe toxicity
developed in the majority of frail patients ,administration
of therapy may cause high risk of life-threatening
AIM: We have considered in this paper ABC in frail
patients like OW. Purpose of the study is preliminary
detection of the overall toxicity (OTox) through the possible use of specifics tests adopted specially in frail patients
such as OW, to ensure greater control in drugs administration with good effectiveness.
Material (patients) and methods: 62 patients with
ABC-p were enrolled between jan2018 dec 2019.
Eligibility Criteria women aging eighty or older;
acquired written consensus; confirmed diagnosis of ABC;
one or two measurable lesions (bone or visceral or both);
no brain secondarisms; Charlson's Comorbidity Scale 1-3
score points; CGA Evaluation permissive for treatment.
CARG-TS (Cancer and Aging Research Group-Test
Score) and CRASH-TS(Chemotherapy Risk Assessment
Scale for High-Age Patients Test S) are rated for predictive assessment of the risk of severe chemotox in all
patients. Further Evaluations tools: Clinical Benefit
according to ESMO CB scale v.2a;Tox Profile CTCAE
v3.0 Criteria; QoL by EORTC QLQ-C30.
Results: CARG-TS predicts severe OTox; CRASH-TS
predicts hematologic non-hematologic toxicity. Using a
combination of CGA-ES+CARG-TS+CRASH-TS, we
were able to divide patients into three categories: LR
Low risk (score0-5); MR: Medium risk (score 5-10); HR
High risk (score over 10).On this basis HR people was
directed to receive endocrine therapy(if ER+PGR+)or
RTalone. The MR group experienced a reduced schedule
of eribulin (0.90mg/sqm d1,d28 until P-progression or
INT-intolerable toxicity. Finally LR group received a
schedule with eribulin alone(E 0.96-1.1 mg/sqm IV on
d1,d21 dosage depending on Creatinine clearance value
according to the Kintzel-Dorr's method and until P or
INT-toxicity).
Conclusions: With contemporary use of CGA-ES ,CARGTS,CRASH-TS we obtained two diagrams, the first "predicted risk" the second "observed risk" for each patient:
the first curve was almost perfectly in line (p<0.001)with
that of the "observed risk". This allowed to have extremely
personalized treatments, negligible OTox, and very good
values for both CB and QoL

Carreca I.1, Bazan V.2, Galvano A.3, Carreca A.P.3, Cusenza S.3,
Russo A.3

NLBA05

1
Cattedra di Oncologia Medica -UniPa-International School of Medical
Sciences Genève CH, Palermo; 2BIND, Palermo; 3Department of Surgical,
Oncological, and Oral Sciences- ^Section of Medical Oncology,- *Medical
Oncology Unit, Palermo

May sarcopenia be a predictive
factor of response to Nivolumab
in recurrent-metastatic head and
neck (RM-SCCHN) cancer patients?



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
Tumori Journal Abstract Book - October 2020 - 2
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Tumori Journal Abstract Book - October 2020 - Cover3
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