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206	
Background: Immunotherapies and molecular targeted
treatments have improved the prognosis of melanoma
patients (pts) both in adjuvant and metastatic setting. Due
to their peculiar mechanism of action, these drugs may
cause typical adverse events (AEs) and many of these may
be severe and life-threatening. In particular, the therapy
with check points inhibitors like anti-PD-1 and anti-CTLA4 agents require a careful monitoring of patients during
the treatment and also after the end due to possible delayed
or permanent adverse events. The aim of our study is to
evaluate whether nursing monitoring of pts through periodical phone calls may be useful to reduce the incidence of
serious adverse events (SAEs) and hospitalizations in melanoma pts treated with immunotherapy.
Methods: We started to collect data from 50 melanoma pts
treated with immunotherapy from March 2020 to May 2020
during COVID- 19 pandemia. Thirty-five (70%) pts were
treated for metastatic disease and fifteen (30%) for adjuvant
aim. Forty-five patients (90%) received an anti-PD-1 treatment (pembrolizumab or nivolumab) and five (10%) an antiCTL-A4, ipilimumab. Phone calls to patients or to their
care-givers were performed by the nurse once weekly and
toxicity was evaluated through CTCAE v5.0 (Common
Terminology Criteria for Adverse Events). Medical interventation was required according the grade or the type of AE.
Results: The incidence of AEs detected on phone calls
were the following in metastatic pts : Grade 1-2 diarrhea
(15/35, 43%), grade 1pruritus (10/35, 28%), grade 2 rash
(5/35,14%), grade 1fatigue (12/35, 34%). Among adjuvant
pts : grade 3 diarrhea (3/15, 20%), grade 2 rash (2/15,13%),
grade 2 arthralgia (1/15, 6%), grade 2 peripheral neuropathy (1/15,6%). No SAEs were detected. All AEs resolved
with an early treatment with corticosteroids taken at home
after medical contact. No hospitalization were necessary.
Conclusions: Our preliminary results show that using a
periodical nursing phone calls during the treatment with
immunotherapy may help to detect earlier AEs and to avoid
SAEs and complications that bring to hospitalization.

U04*
RETROSPECTIVE OBSERVATIONAL
STUDY OF SIDE EFFECTS IN PATIENTS
RECEIVING HIGH-DOSE CHEMOTHERAPY
DURING AUTOLOGOUS AND
ALLOGENEIC TRANSPLANTATION AT
THE PIACENZA HAEMATOLOGY UNIT
Cappucciati L.1, Rosselli M.1, Contini A.1, Muroni L.1, Imbriani P.1,
Pattini G.1, Scopelliti R.1
1

Ospedale Guglielmo da Saliceto, Piacenza

Background: In haematopoietic stem cell transplantation,
patients are subjected to regimens with high-dose chemotherapy. High-dose chemotherapy often causes side effects

Tumori Journal 106(2S)
and complications in these patients that negatively interfere with the function of the patient's organs,ausing multiple disorders.he primary endpoint of this study is to detect
the most frequent side effects in such patients depending
on the regimen of conditioning or mobilization to which
they are subjected. Other objectives are to assess whether
there is an incidence of side effects associated with procedures and/or therapies (transfusions, infections) Another
significant goal is to detect whether patients who first had
CSE mobilisation followed by an autologous transplant
show the same symptoms.
Method: The retrospective observational type of study
analyzed a sample of records about 73 patients,30 of whom
having undergone allogeneic transplant while the other 43
the autologous one,who were admitted to the CTMO haematology in the lass of time between January 2017 December 2018.
Results: Results showed that the most frequent symptoms
were fever (96%), mucositis (95%), nausea (84%), diarrhoea (73%), vomiting (71%), asthenia (68%) and pain
(55%). Each sympotom has occurred in a more or less significant way depending on the type of conditioning or
mobilization regimen. Moreover, as may be seen by the
resulting data of this study, it is possible to confirm an
important incidence between the appaerance of side effects
and the concomitant performance of some therapies and
procedures. In particular, transfusions have been shown to
have a high statistical significance in relation to fever,
mucositis,nausea, while infections have a significant effect
on fever and mucositis, not on nausea. I can be concluded
that the same patients who had undergone CSE mobilisation and autologous transplantation never had the same
symptoms altogether: 15% of the patients did not show
matching symptoms, while the remainder of them did. In
particular 23% of all patients presented one equal symptom, 32% developed two symptoms in common,18% three
symptoms, 9% had 4 symptoms and only 3% 5 symptoms.
Conclusions: The analysis of the data obtained allows to
take into consideration the possibility of preventing the
occurrence of the most frequent side effects through a preventive chemotherapeutic- based treatment administered
during the conditioning or mobilisation regimen, in order
to improve the quality of life, the patient'care.

U05*
PAIN EVALUATION AND TREATMENT
IN HOSPITALIZED PATIENTS WITH
METASTATIC CANCER. A PROSPECTIVE
STUDY ON IMPACT OF NURSING
EVALUATION FOR PAIN MANAGEMENT
IMPROVEMENT
Giordani P.1, Profili S.1, Rinaldi D.1, Bianchi R.1, Dionigi F.1, Della
Chiara J.1, Aporta G.1, Montanari G.1, Nardi C.1, Matsko I.1,



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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