Tumori Journal Abstract Book - October 2020 - 201

T - Miscellanea	

201

of May 2020, median progression-free survival (mPFS)
was 18,1 months (m) (range 4 - 43) and the median overall survival (mOS) was 41,2m (range 4 - 184). 23 pts are
still receiving IT whereas 7 died. IrAEs were correlated
both with longer OS (mOS not reached -NR versus -vs 49
m in pts without IrAEs - 95%CI:27-60; p=0,0014) and
longer PFS (mPFS NR vs 26 m -95%CI: 9-35 m;
p=0,0462). Pts with melanoma and kidney cancer had
longer PFS (mPFS: NR) than lung and urothelial cancer
(mPFS: 25 m and 3 m, respectively).
Conclusions: Even if retrospective and with small sample
size, our study suggests that IT is effective, safe, and welltolerated by elderly pts in the same way as in adult pts, as
confirmed by available literature data. The immunosenescence didn't affect the efficacy and the onset of IrAEs.

Conclusions: From the comparison with the general population (T-Test for homogeneity), a greater tendency emerges to
develop a condition of distress that could interfere with the
entire path of the CGO, especially in the process of understanding information; in sharing the outcome to the family
context; in choosing between a clinical surveillance pathway
vs surgical prophylaxis. Personalized and integrated psychological pathways could therefore represent a protective factor for the well-being of patients who access CGO.

T48

Ghidini A.1, Ferrari D.1, Cerioli C.1, Savorana R.1, Vas L.1, Viadana S.1,
Bukovec R.1, Crepaldi C.1, Roncari L.1, Pancera G.1

Personality factors, family
dynamics and risk of psychological
distress in oncological genetic
counseling BRCA 1-2
Moschetto M.1
1

A.O.U. Policlinico Vittorio Emanuele - U.O Oncologia Medica, Catania

Backgroud: Oncological genetic counseling (CGC, NSGC,
Resta et al., 2006), in Italy since 2013 called CGO
(Oncological Genetic Counseling, AIOM, SIGU, 2013),
identifies genetic mutations for hereditary neoplastic disease. To date, literature is scarce in relation to the psychosocial factors that characterize patients who follow this path. A
deeper understanding would take on clinical relevance in
order to identify patients at risk of negative effects subsequent (or previous) to the test and implement consultancy
protocols that minimize these effects by also providing tailored psychological support interventions (Lerman, 2008).
The present observational study is part of this context with
the aim of describing a psychological profile that distinguishes the patient with breast and / or ovarian cancer with
previous individual and / or family history of disease accessing the CGO. SAMPLE: In the CGO outpatient clinic of the
A.O.P.V.E. of Catania 87 SS were recruited (average age =
48.2; interval 22-64;) with a diagnosis of breast K (N = 35)
and / or ovary (N = 10). The present study was conducted
during the first preliminary interview of the CGO course.
Material and Method: Each patient underwent a preliminary interview followed by a semi-structured interview
during the pre-test consultation and subsequently, in the
form of a self-report, he completed the SCL-90-R
(Derogatis, 1994); the BFQ (Caprara et al. 1993), the
FACES IV (Olson, 2007).
Results: Research is still ongoing. Preliminary data show
a tendency towards psychosocial vulnerability correlated
with age, family cohesion, cognitive flexibility, experiences of anxiety and depression.

T49
Scalp-cooling device to prevent
alopecia in women receiving
chemotherapy for breast or
gynecologic cancers

1

Casa di Cura Igea, Milano

Background: Alopecia is a very important side effect for
women treated with chemotherapy. Scalp-cooling may
reduce hair loss during treatment for cancer.
Patient and methods: Paxman scalp-cooler is a device
available in our Institution from 2017. We prospectively
collected data of patients receiving chemotherapy for
breast and gynecologic cancers. Scalp-cooling was performed with temperature of -4°C from 30 minutes before
chemotherapy until 100 minutes afterwards. Efficacy and
safety of the device were reported in medical records; alopecia was graded according to CTCAE v.5.0.
Results: From September 2017 to April 2020 we collected
data of 50 patients; median age was 55. 94% were breast
cancer: 8 women were treated in neoadjuvant and 38 in
adjuvant setting with 4 cycles of doxorubicin and cyclophosphamide (1 patient also paclitaxel, another patient
carboplatin and paclitaxel, another one paclitaxel plus trastuzumab). Median scalp-cooling cycle were 3,5 (range
1-4). 7 patients stopped use of the cap because of intolerance like headache, cold sensation and neck pain. 9 patients
had to use a hair wig. Rate of success was 62% (4 patients
without alopecia and 27 patients with alopecia G1).
Conclusions: Our data suggest that use of device scalpcooler like Paxman reduce alopecia in more than half of
women treated for breast or gynecologic cancers, with
good tolerability.

T50
CHECK POINT INHIBITORS' TREATMENT
IN REAL WORLD SETTING
Filipazzi V.1, Gambaro A.1, Ferrario S.1, Cona S.1, Rota S.1, Tosca N.1,
Dalu D.1, Fasola C.1, Somma L.1, La Verde N.1
1

ASST-FBF-SACCO, Milano



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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