Tumori Journal Abstract Book - October 2020 - 199

T - Miscellanea	
Conclusions: The study has allowed to identify the needs of
pts and to activate the psychological and nutritional service
in the target hospitals. All the pts involved appreciated the
service. Currently follow-ups are done using smart-working
or by phone and mail for the COVID-19 emergency.

199
Conclusions: The small number of patients limits the interpretation of our results. However, our data suggest that IL-2
and CCL-2 might predict good and poor PFS respectively.

T45
T44
TRANSLATE: Activation of immune
response in refractory patients
to standard treatment
Abbona A.1, Garrone O.2, Falletta A.1, Fea E.2, Paccagnella M.2, Lo
Nigro C.3, Gammaitoni L.4, Vanella P.2, Monteverde M.2, Granetto
C.2, Occelli M.2, Denaro N.2, Merlotti A.2, Reali A.2, Sangiolo D.4,
Merlano M.2
1
Department of Traslational Oncology, Ospedale S.Croce e Carle Cuneo,
Cuneo; 2Ospedale S.Croce e Carle Cuneo, Cuneo; 3E.O. Ospedali Galliera,
Genova, Genova; 4IRCCS Candiolo Institute, Turin, Torino

Background: The TRANSLATE exploratory study tests
changes of cytokines over treatment with metronomic
cyclophosphamide, daily low dose of IL-2 every other
week, and 8 Gy single fraction RT (self vaccination) in
end-stage solid tumors.
Patients and methods: Patients with end stage tumors
with no further standard treatment available were eligible.
A panel of 17 cytokines was analysed. Plasma concentrations were assessed at baseline (T0), day 8 (after RT) (T1),
day 28 (T2), and at disease progression (PD) (T3), using
Simple Plexsystem (ProteinSimple, USA). Patients were
divided in two groups depending on the time of PFS (group
A<3 months, group B>3 months). Values at each time
points were compared and correlated to outcome. P<0.05
was considered for statistical significance.
Results: 23 patients with breast, colon, kidney and prostate
cancer were enrolled. IL-2 progressively increased from T0
to T2 (T0-2 P<0.001; T1-2 P=0.002) and decreased at T3.
IL-5 progressively increased from T0 to T2 (T0-2 P=0.005;
T1-2 P=0.049) and decreased at T3 (T2-3 P=0.048). IL-8
remained stable along the treatment but increased at T3 (T0-3
P=0.057; T1-3 P=0.022; T2-3 P=0.018). CCL-4 decreased
from T1 to T2 (P=0.040) but increased at T3 (P=0.008). IFN╬│ progressively decreased from T1 to T3 (T1-3 P=0.026; T2-3
P=0.034). VEGF performance differed between group A and
B: while it remained stable in group B, increased from T0 to
T1 in group A. However, considering all together, VEGF
increased at T3 compared to T0 (T0-3 P=0.022). Using ROC
analysis at T0 we identified cut-off values for IL-2, IL-12, and
CCL-2. Using them, we observed a significant improvement
in PFS in patients with values of IL-2 and IL-12 higher than
their respective cut-offs and with CCL-2 lower than its cut-off
(HR 0.33, P=0.03; HR 0.32, P=0.029; HR 0.37, P=0.049;
respectively). We performed a multivariate analysis coupling
these three cytokines two by two. Only IL-2 and CCL-2
remained associated with PFS.

When a doctor becomes a patient:
an overview of an atypical point
of view
Donisi C.1, Massa E.1, Liscia N.2, Lai E.1, Tolu S.2, Pireddu A.2,
Balconi F.1, Persano M.1, Mariani S.1, Pinna G.1, Impera V.2, Musio
F.1, Dubois M.1, Migliari M.1, Spanu D.1, Saba G.1, Pretta A.2,
Sancassiani F.1, Carta M.G.1, Madeddu C.1, Scartozzi M.1
1
Medical Oncology Unit, University Hospital and University of Cagliari,
Cagliari, Italy, Cagliari; 2Medical Oncology Unit, Sapienza University of RomeUniversity Hospital and University of Cagliari, Cagliari, Italy, Cagliari

Background: In 2018, were reported 18,078,957 new cancer cases worldwide. Cancer does not spare doctors but
there is a lack of data in the literature on this topic. Thus,
an open prospective study was conducted. Its primary endpoint was to evaluate in a sample of doctors becoming cancer patients how their medical background influences
some aspects of their life. The secondary endpoint was to
validate a questionnaire based on the collected answers.
Material and Methods: An open interview was administered to them by an interviewer (table 1). Table 1. Topics
explored in the open interview: How being a doctor influenced the cancer diagnosis? What was your reaction to the
diagnosis? Had you looked into the staging, the prognosis,
and the therapies of your cancer? How did you choose the
oncologic team? Did you receive support from your family,
friends, and colleagues? Were you concerned about the loss
of your privacy? Had you lost interest in your job? Did you
realize that you're not able to do the same job as before?
How did you react? Had you been demoted? Were you
forced to do it? Did you become more sympathetic with
your patients? Did you become more sensitive to unfair
behavior towards the patients? Were you a victim of discrimination as a patient? Did your work planning change?
Did your consideration of your private life change?
Results: From April to May 2020, ten doctors becoming
cancer patients were enrolled, mean age 57,2 years (range
39-79), M/F 4/6 with the following tumors: lung cancer 1,
prostate cancer 2, breast cancer 4, melanoma 1, thyroid cancer 1, ovarian cancer 1, colon-rectal cancer 1. One patient
had two primary cancers. Their medical specialty was: orthopedic surgeon, general practitioner, endocrinologist, physiatrist, oncologist, anesthetist, geriatrist, gastroenterologist,
and doctor of public and environmental health. All patients at
the time of diagnosis were actively employed and working.
From the collected answers, it turned out that all patients
were sure about the choice of the oncologic team and none of
them asked for a second opinion; 70% of patients were aware
of their inability to work as before cancer. Consequently, the



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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