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188	
and non- disease related factors, including socio-cultural,
environmental, and psychological attributes. It derives
both from costs related to assistance and borne on the
patients and its caregivers, and reduction of income capacity also in this case borne on the patients and on the caregivers. Stress levels may escalate to significant
proportions in some patient, to present with symptoms of
anxiety especially during therapy administration periods.
Materials and Methods: In order to highlight financial toxicity related to the diagnosis of metastatic pancreatic and
lung cancer and to measure its evolution over time and any
correlation with the prognosis, we developed a questionnaire
called FT16 and we conducted a validation study on a sample of 31 patients. The design of the study involved the
development and the psychometric assessment of a scale to
measure the perceived sources of FT among CP. Following
extensive literature review, a table of specification with the
initial items was created to guide item construction for developing the scale. The items related to these FT were converted
into a 16-item, multipoint questionnaire. We also monitored
quality of life of the patients, using the QlQ C-30 questionnaire to capture correlation between FT onset and quality of
life deterioration; clinical characteristics of the patients,
response to therapy and outcome parameters also have been
recorded to evaluate eventual correlation with FT.
Results: The questionnaire was administered to 31 CP,
both men and women, who were newly diagnosed and
will undergo cancer treatment. Each of them has been
informed about the research and written informed consent has been obtained. FT16 internal consistency reliability (Cronbach's alpha) was 0.77. To assess the tool's
ability to detect FT, a multiple linear regression model
was applied, demonstrating how much the dependent
variable of the individual's perception of economic difficulty (item n.16) could be predicted by the remaining
independent variables (items n.1-15). The result showed
a r-square index of 0.78 (p=0.018).
Conclusions: FT16 questionnaire seems to be a useful tool to
capture FT onset in this poor-prognosis subset of patients; the
analysis of the data recorded will continue to assess the capability of the FT16 to capture correlations with clinical characteristics at diagnosis and correlations with the prognosis.

T24
C-Kit Receptor and Tryptase
Positive Mast Cells Correlate
with Normal To Cancerous Tissue
Shifting and Angiogenesis in
Pancreatic Cancer
Ranieri G.1, Laface C.1, Zuccalà V.2, Luposella F.3, Zizzo N.4, Patruno
R.4, Porcelli M.5, Gadaleta C.D.5, Ammendola M.6
1
Interventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo
II", Bari; 2Pathology Unit, "Pugliese-Ciaccio" Hospital, Catanzaro, Italy;

Tumori Journal 106(2S)
3
Direction Départementale de la Cohésion Sociale et de la Protection des
Populations des VOSGES (DDCSPP88), Vittel, France; 4Chair of Pathology,
Veterinary Medical School, University "Aldo Moro" of Bari, Bari, Italy;
5
Interventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo
II", Bari, Italy; 6Department of Health Science, Digestive Surgery Unit,
University "Magna Graecia" Medical School, Catanzaro, Italy

Background: Mast cells (MCs) contain pro-angiogenic
factors, in particular tryptase, associated with tumoral
angiogenesis. Up to now few data have been published on
the role of MCs in angiogenesis in both pancreatic ductal
adenocarcinoma tissue (PDAT) and adjacent normal tissue
(ANT).
Methods: In this study MCs density positive to C-Kit
receptor (MCDP-C-KitR), MCs density positive to tryptase
(MCDPT), MCs area positive to tryptase (MCAPT), angiogenesis in terms of microvascular density (MVD) and
endothelial area (EA) were evaluated by immunohistochemistry and image analysis in both PDAT and ANT.
Tissue samples were obtained from 45 patients with stage
T2-3N0-1M0 (by AJCC for Pancreas Cancer Staging 7th
Edition) who had undergone surgery. For each analyzed
tissue parameter mean ± standard deviation was evaluated
in both PDAT and ANT and differences were calculated by
Student t-test (p ranged from 0.001 to 0.004). Each analysed tissue parameter was correlated each other by
Pearson t-test analysis (p ranged from 0.01 to 0.03). Any
other correlation among MCDP-C-KitR, MCDPT,
MCAPT, MVD, EA and the main clinical pathological
characteristic was found.
Results: The mean value ± standard deviation (SD)
regarding MCDP-C-KitR, MCDPT, MCAPT, MVD and
EA in TT was 14.69±4.57, 13.31± 4,23, 171.41±62,39
µ2, 29.11±7.93, 201.82±70.05 µ2 respectively and the
mean value ? SD in ANT was 5.61 ± 2.39, 5.13 ± 2.03,
54.43 ± 16.73 µ2, 11.45 ± 4.96, 67.60 ± 21.96 µ2, respectively. Differences in terms of mean value ? SD between
PDAT and ANT were significant for each analyzed tissue
biomarker. Data demonstrated that MCDP-C-KitR
MCDPT, MCAPT, MVD and EA significantly increased
from ANT to PDAT. In PDAT, it was showed a correlation
between MCDP-C-KitR and MCDPT (r= 0.87, p= 0.01),
MCDP-C-KitR and MVD (r= 0.74, p= 0.02), MCDP-CKitR and MCAPT (r=0.81, p= 0.01), MCDPT and MVD
(r= 0.72, p= 0.02), MCD-C-KitR and EA (r= 0.73, p=
0.02), MCDPT and MCAPT (r=0.85, p= 0.01), MCAPT
and MVD (r=0.76, p= 0.02), MCAPT and EA (r=0.66, p=
0.03), MCDPT and EA (r= 0.69, p= 0.03), MVD and EA
(r= 0.82, p= 0.01).
Conclusions: Our data suggest that assessed tissue parameters increased from ANT to PDAT and that MCs are
strongly associated with angiogenesis in PDAT. On this
basis, inhibition of MCs by tyrosine kinase inhibitors, such
as masitinib, or inhibition of tryptase by gabexate mesylate
may be a novel antiangiogenetic approach in pancreatic
cancer therapy.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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