Tumori Journal Abstract Book - October 2020 - 185

T - Miscellanea	

185

Area Medica, Università degli studi di Udine; Dipartimento di Oncologia,
Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine; 4Dipartimento
Oncologia, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine

Background: In the last years, the development of immune
checkpoint inhibitors (ICI) is leading to major changes in
oncology workload. As very few data are available on this
topic, we conducted a study to estimate the shift in workload generated, within 1 year of first consultation, by any
new metastatic cancer patient receiving ICI at the Oncology
Department of the Academic Hospital of Udine, Italy.
Patients and methods: We collected from our electronic
accountability system all new first consultations for metastatic cancer between 01.01.2017 and 31.12.2018, leading to at least a second clinical episode (treatment
sessions, unplanned presentations, hospitalizations, reevaluations, follow-up, and inpatient oncology advices)
during the following year. Patients (pts) were divided

into those receiving ICI (anti-CTLA4/PD1/PDL1) versus
pts receiving other treatments. Mean number per patient
and standard deviation were calculated for clinical episodes, and the mean numbers in each group were compared using Student's t-test (significance p<0.05).
Follow-up continued until 31.12.2019.
Results: 969 pts were included (115 ICI; 854 other treatments). Pts treated with ICI generated a statistically significant greater workload in terms of treatment sessions,
re-evaluations, and unplanned presentations. On the other
hand, follow-up visits workload was greater for other
treatments group. In detail, data are reported in Table 1.
Conclusions: ICI have transformed the oncology landscape, leading to increasing survivals and longer lasting
treatment periods. The estimate of workload generated by
new diagnosis of metastatic cancer requiring ICI is crucial
for implementing more sustainable systems and for planning clinical activities.

Table1.  Mean number of clinical episodes in the first year of treatment with ICI for metastatic disease.
Metastatic disease

Treatment Follow-up
sessions
visits

Hospitalizations Inpatient
oncology
advices

Re-evaluations Unplanned
Total n° of
presentations patients

Other cancer
treatments

6.83
0.83
(SD 6.48) (SD 1.24)

0.73
(SD 1.58)

0.58
(SD 1.09)

1.88
(SD 1.77)

1.51
(SD 2.63)

total episodes (N=10548)

N=5829

N=623

N=493

N=1605

N=1287

Immunotherapy

9.59
0.63
(SD 5.99) (SD 0.99)

0.61
(SD 1.04)

0.60
(SD 1.36)

2.55
(SD 1.87)

2.19
(SD 2.42)

N=1103
<0.0001

N=70
0.2784

N=69
0.8641

N=293
0.0002

N=252
0.008

total episodes (N=1859)
P value

N=711

N=72
0.0432

854

115

 

Mean number per patient is represented by mean value and standard deviation (SD). Total number of clinical episodes is shown
(N=). Data are reported for ICI versus other treatments group.

T19
Preliminary impact analysis
of recycling discarded oral
anticancer drugs: a single centre
evaluation
Chini C.1, Ciotti O.1, Conti S.1, Simonetti L.1, Boni E.1, Gabri P.1, Galli
D.1, Vallini I.1, Pinotti G.1
1

ASST Settelaghi Varese, Varese

Background: targeted oral agents represent one third of
treatment for many cancers. The high cost of the new oral
anticancer drugs is well known. In particular, the financial
toxicity of new molecules to health institutions and indeed
to society is increasingly recognized. Often oral treatments
are discontinued because of toxicities, disease progression

or death in almost all patients (pts). On the other side pts
adherence represents an essential component in evaluating
effectiveness of oral medications. As a result, many of
them have unused amount of tablets when their treatments
are discontinued. We believe that it's time to directly
empower physicians who are motivated to be able to recycle drugs, thus increasing access and minimizing waste.
The aim of our survey was to explore patients' compliance
with oral drugs and to identify the amount of waste drugs.
Material and methods: From August 2019 to January 2020
we dispensed 590 cycles of different oral anticancer drugs to
pts referred to our Institution. During the delivery we asked
pts to fill in a questionnaire in order to evaluate drug's compliance, adherence and persistence. Wasted tablets were calculated after any cycle. The amount associated with the
wastage was determined using the average wholesale price.



Tumori Journal Abstract Book - October 2020

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Contents
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Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
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Tumori Journal Abstract Book - October 2020 - Cover3
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