Tumori Journal Abstract Book - October 2020 - 183

T - Miscellanea	

183

Pugliese G.1, Baldessari C.1, Guaitoli G.1, Greco S.1, Vitale M.G.1,
Depenni R.1, Barbieri F.1, Sabbatini R.1, Dominici M.1

Angelini F.1, Rossi L.2, Tomao S.3, Cimino G.4, Mannino A.2, Conte
D.1, Lo Russo V.1, Gozzi E.2

1

1
Ospedale Regina Apostolorum Albano laziale, Albano; 2Università la
Sapienza di Roma, Aprilia; 3Università la Sapienza di Roma, Roma;
4
Università la Sapienza di Roma, Latina

University Hospital of Modena, Modena

Background: The landscape of non-small cell lung cancer
(NSCLC), melanoma (M), renal cell carcinoma (RCC) and
urothelial cancer (UC) has changed with the advent of
immunotherapy (IT). IT is generally well tolerated, but
adverse events may occur requiring use of steroids.
Patients and Methods: We conducted a retrospective analysis of 391 patients (pts) who received at least 1 dose of IT
at AOU Policlinico di Modena. Overall survival (OS) curves
were built using the Kaplan-Meier method. Log-rank test
was made to compare OS within groups according to steroid
use (no or yes for toxicities (tox)/yes for other reasons), high
doses of steroid use (<15 mg prednisone or equivalent/>=
for tox/>= for other reasons) and duration of steroids use
(no or <1 month/>=1 month/continuous).
Results: Our series included 56,8% NSCLC, 29,7% M,
8,7% RCC and 4,8% UC. 29,9% of pts received IT in 1st
line. At cut off time (reappraisal time), 325 pts (83,1%)
showed disease progression and 247 (63,2%) were dead.
Most pts had a good performance status (ECOG 0-1 88,7%)
and were male (67,5%). 51,9% of pts had tox of any grade
and types. 10% had Grade 3-4 tox. 77 pts used steroids for
IT tox, 146 for other reasons, 151 made no use and for 17
data were unavailable. OS according to steroid use in the
whole population was significantly longer for pts who never
had steroids or used for tox vs others (p<0,0001) and this
was noted also among cancer types: NSCLC (mOS 15 vs
6,1 months (mo), p<0,0001), melanoma (mOS 19,4 vs 3,5
mo, p<0,0001) and RCC (mOS 31,1 vs 7,4, p=0,0393). In
UC mOS was 13,4 vs 3,3 mo, p=ns, due to small number of
pts. OS according to high doses of steroids were 9,6 without
high doses vs 23,9 mo for high doses for tox vs 5,7 mo for
high doses for other reasons (p<0,0018) for NSCLC and
14,7 vs 22,2 vs 3,5 mo, respectively (p<0,0001) in melanoma. Regarding OS according to steroid therapy duration:
in NSCLC mOS without or with short use was 15,8 vs 10,7
for prolonged use vs 5,6 mo for continuous use, p<0,0001
and in melanoma mOS was 14,7 vs 19,3 vs 3 mo, respectively, p=0,001.
Conclusions: Our data confirmed that steroid use, especially
for toxicities management and for short cycles, doesn't
impact on outcome of pts treated with IT in any lines of therapy. The treatment of toxicities is important for quality of life
and must be done without fearing detrimental effect on IT.

T15
Prognostic value and safety of
lymphocyte-to-monocyte ratio
(LMR) in immunotherapy in solid
tumours

Background: Lymphocyte-monocyte ratio (LMR) represents a new marker of chronic systemic inflammatory
response. Several studies examin the prognostic role of
LMR in patients undergoing chemotherapy, while in
immunotherapy there is minor evidence. In our study, we
aimed to investigate the prognostic value of LMR and its
correlation with immunotherapy toxicity in solid tumours.
Patients and methods: We enrolled 93 patients (pts) with
advanced solid tumours treated with immunotherapy.
80 pts (86%) had non-small-cell lung carcinoma (NSCLC),
4 (4.3%) had renal cell carcinoma (RCC) and 9 (9.6%) bladder cancer. Mean age was 70 years (range 48-82). Pretreatment LMR was calculated by division of lymphocyte to
monocyte measured in peripheral blood. Pts were divided
into two groups based on the average LMR value found
(LMR< 3.6 and LMR > 3.6). We evaluated response and
safety of the treatment in relation to LMR value.
Results: 61/93 pts (65.5%) had low LMR, 32/93 (34.4%)
had high LMR. At the fist instrumental evaluation, 37 pts
with low LMR had disease progression (PD) (60.8%), while
16 pts stable disease (SD) (26.2%), 7 showed partial response
(RP) (11.4%), 1 had complete response (RC) (1.6%), with a
clinical benefit (CB) (RC+RP+SD) of 39.3%. Pts with high
LMR, 12 had PD (37.5%), 9 SD (28.2%), 11 RP (34.3%),
with CB of 62.5%. We examined several immune-related
toxicities and for some of these we found differences between
the groups examined: low LMR versus (VS) high LMR:
Diarrhea/Colitis ( 21.3% VS 9.3%), Hematological toxicity
(24.5% VS 3.1%), Endocrine toxicity (42.6% VS 15.6%),
hepatic toxicity (37.7% VS 0), Itching (27.8% VS 9.3%),
Nausea and vomiting (21.3% VS 6.2%).
Conclusions: Our results suggest that low pre-treatment
LMR is associated with lower response rate and greater
incidence of toxicity in patients with advanced solid
tumours treated with immunotherapy LMR could be considered prognostic and safety markers.

T16
Oncology Clinical Trials
management during the pandemic the Italian experience
Cresta S.1, Franchina V.2, Maggiora P.1, Stabile S.3, Taverniti C.4,
Federici I.5, Monti M.6, Guarrera A.7, Testoni S.6, Cagnazzo C.4
1

Ospedale Maggiore della Carità, Novara; 2AOU Papardo, Messina;
Ospedale Niguarda, Milano; 4AOU Città della Salute e della Scienza, Torino;
5
Spedale Riuniti, Ancona; 6Istituto Scientifico Romagnolo per lo Studio e la
Cura dei Tumori, Meldola; 7AOU Careggi, Firenze
3



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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Tumori Journal Abstract Book - October 2020 - Cover3
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