Tumori Journal Abstract Book - October 2020 - 18

18	
Auto-antibody, Lymphocyte subsets monitoring and flow
cytometry analysis of NK cells in patients receiving
Atezolizumab deserve to be investigated as a potential biomarker of response and immunerelated adverse events in
patients with NSCLC receiving PD-1/PDL1 immunecheckpoint blockade.

A25
Prognostic implication of soluble
Programmed Death-Ligand 1 in
patients with Non-Small Cell
Lung Cancer treated with immune
checkpoint inhibitors
Dellepiane C.1, Coco S.1, Dal Bello M.G.1, Rossi G.1, Rijavec E.2, Biello
F.3, Tagliamento M.1, Longo L.1, Mora M.1, Anselmi G.1, Alama A.1,
Bennicelli E.1, Grossi F.2, Zullo L.1, Beshiri K.1, Bottini A.1, Pronzato
P.1, Genova C.1
1
IRCCS Ospedale Policlinico San Martino, Genova; 2Fondazione IRCCS Ca'
Granda Ospedale Maggiore Policlinico, Milano; 3AOU Maggiore della Carità,
Novara

Tumori Journal 106(2S)
In Pembro cohort, median overall survival in low and high
sPD-L1 level groups were 16.0 and 10.9 months, respectively (p=0.045). No difference in progression-free survival or objective response was observed. In Nivo cohort,
sPD-L1 was not associated with clinical outcomes.
Conclusions: Our study shows that baseline sPD-L1 is
associated with poor prognosis in advanced NSCLC
patients treated with Pembro in first line. sPD-L1 was not
prognostic for pre-treated patients receiving Nivo.
Additional analyses on longitudinal sPD-L1 assessments
are ongoing.

A26
Prognostic value and safety
of neutrophil to lymphocytes
ratio (NLR) and platelets to
lymphocytes ratio (PLR) in NSCLC
treated with Nivolumab
Gozzi E.1, Rossi L.1, Raimondi L.1, Cimino G.2, Angelini F.3, Conte D.3,
Lo Russo V.3, Tomao S.4
1

Background: Immune checkpoints inhibitors (ICIs) have
revolutionized the treatment of advanced non-small cell
lung cancer (NSCLC). PD-L1 expression on tumor specimens is the only approved predictive biomarker (tissue
PD-L1, tPD-L1). However, the outcome of patients treated
with ICIs is frequently independent from tPD-L1 status;
thus, more suitable biomarkers are needed. In this study, we
analyzed the role of soluble PD-L1 (sPD-L1) collected from
the peripheral blood of patients with advanced NSCLC
treated with nivolumab (Nivo) or pembrolizumab (Pembro).
Patients and methods: We evaluated sPD-L1 in baseline
plasma samples withdrawn from 196 advanced NSCLC
patients, including 118 patients treated with Nivo in second or further lines (range: 1-6 previous lines), 56 patients
with high tissue PD-L1 expression (tPD-L1⩾50%) treated
with Pembro in first line, and 22 patients with low tissue
PD-L1 expression (tPD-L1<50%) treated with chemotherapy (Chemo); additionally, we evaluated sPD-L1 from
88 healthy donors. sPD-L1 was analyzed with enzyme
linked immunosorbent assay (ELISA), by using Dako
PD-L1 28-8 pharmDx assay. We explored correlations
between sPD-L1 and clinical outcomes of Pembro cohort
and Nivo cohort. In addition, we compared sPD-L1 with
tPD-L1 in previously untreated patients (Pembro cohort
and Chemo cohort).
Results: The sPD-L1 median concentration of 23.92 pg/
ml was used as cut- off. sPD-L1 level was higher in patients
with advanced NSCLC compared to healthy controls
(p<0.0001). Moreover, we found higher concentration of
sPD-L1 in previously untreated patients with tPDL1⩾50% versus patients with tPD-L1<50% (p= 0.033).

Università La Sapienza di Roma, Aprilia; 2Università La Sapienza di Roma,
Latina; 3Ospedale Regina Apostolorum Albano Laziale, Albano; 4Università La
Sapienza di Roma, Roma

Background: NLR and PLR are inflammation-associated
indexes.
Pre- treatment high NLR and PLR suggest worse prognosis with lower response rates in patients with NSCLC
treated with immunotherapy.
In our study, we aimed to investigate the prognostic value
of NLR and PLR and their correlation with immunotherapy toxicity in NSCLC treated with Nivolumab.
Patients and methods: We enrolled 65 patients (pts) (35
men and 30 women) with advanced NSCLC treated with
Nivolumab. Mean age was 70 years (range 48-82).
Squamous and non squamous histologies were diagnosed
in 35 (53,8%) and 30 (46,1%) pts, respectively.
Pre-treatment NLR and PLR were calculated by division
of neutrophils and platelets by lymphocytes measured in
peripheral blood
Pts were divided into groups based on the NLR value
(NLR <3 and NLR ⩾3) and PLR value (PLR< 170 and
PLR ⩾170).
We evaluated response and safety of the treatment in relation to NLR and PLR value.
Results: Regarding NLR, 30/65 pts (46,1%) had high
value, 35/65 (53.9%) had low value.
At the fist instrumental evaluation, 21 pts with high NLR
had disease progression (PD) (70%) while 2 pts (6.6%)
showed partial response (RP) and 7 (23.3%) stable disease
(SD), with a clinical benefit (CB) (RC+RP+SD) of
29.9%.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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Tumori Journal Abstract Book - October 2020 - Cover3
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