Tumori Journal Abstract Book - October 2020 - 179

T - Miscellanea	
(27.4%) HPV-negative, were analyzed. In the anal SCC setting, patients with low eosinophil count (<100 10^9/L) had
a better DFS; at the multivariate analysis eosinophils showed
to be independent prognostic factors for DFS (HR=0.59;
95%CI: 0.36-0.97; p= 0.0392). In HPV-positive HNC
patients low eosinophil count showed to be related to a better
DFS at univariate analysis, with no confirmation at multivariate. HPV-negative HNC patients with low eosinophil
count had a worse DFS respect patients with high eosinophil
count (> 100 10^9), ad after adjustment for age and sex,
eosinophils have been confirmed as independent prognostic
factors for DFS (HR=4.55; 95%CI: 1.36-15.22; p= 0.0139).
Conclusions: Peripheral eosinophil count could be used as
predictor of response to CT-RT in HPV-positive anal
SCCs. The worse prognosis showed in HPV-positive
patients with high eosinophil count is likely to derive from
the immunomodulation induced by both HPV and eosinophils, which frustrate the RT benefic effects.

T07
Relevance of pharmacogenetic
variant in DPYD and MTHFR genes
for fluoropyrimidine basedchemotherapy
Cafiero C.1, Cito P.2, Friscini A.3, Luccarelli G.3, Brunetti C.4, Modoni
G.3, Russo F.3, Fanelli F.3, Nenna C.3, D'Alessandro A.R.3, Pastore
C.3, Galeano T.3, Broussard C.3, Nisi C.3, Bruno M.3, Brunetti A.E.5,
Lazzari G.6, Silvano G.6, Vinci M.V.7, Pisconti S.3
1
Struttura Complessa di Oncoematologia ASL TA, Ospedale S.G. Moscati,
Taranto; 2Struttura Semplice Terapie Oncologiche ASL TA, Ospedale San Pio,
Castellaneta (TA); 3Struttura Complessa di Oncologia ASL TA, Ospedale S.G.
Moscati, Taranto; 4Struttura Complessa di Oncologia ASL TA, Ospedale Polo
Orientale, Manduria; 5Struttura Semplice di Terapie Oncologiche ASL TA,
Ospedale San Pio, Castellaneta (TA); 6Struttura Complessa di Radioterapia
Oncologica ASL TA, Ospedale S.G. Moscati, Taranto; 7Direzione Medica ASL
TA, Ospedale S.G. Moscati, Taranto

Background: Fluoropyrimidine (5-FU) drugs are extensively used for the treatment of solid cancers. The major
targets of 5-FU are folate-metabolizing enzymes and
methylenetetrahydrofolate reductase genes, one of more
commonly known MTHFR (methylenetetrahydrofolate
reductase). Deleterious polymorphisms in some genes may
result in that causes life-threatening toxicities when the
standard dose of fluorouracil is used. Adverse drug reactions are a major clinical problem, often necessitating dose
reduction and treatment discontinuation. Diarrhoea, mucositis, myelosuppression and hand-foot syndrome are the most
frequent and troublesome side effects. Currently available
pharmacogenetic guidelines suggests in the pre-treatment of
Fluoropyrimidine drugs the diagnostic test of five DPYD
genetic polymorphisms c.1905+1 G>A rs3918290, c.1679
T>G (rs55886062), c.2846 A>T (rs67376798), c.1236
G>A (rs56038477), c.2194 G>A (rs1801160). Current evidences of pharmacogenomics report the association of

179
Fluoropyrimidine drugs with toxicity (P<0.0001) of
MTHFR c.1298GG homozygous genotype.
Methods: A cohort of 50 patients (30M/20F; age range
50-70) admitted to the " S.G. Moscati Hospital" (January
- April 2020) candidates for Fluoropyrimidine treatment
are tested by molecular analysis for five DPYD genetic
polymorphisms and for MTHFR C677T (rs1801133) and
MTHFR A1298C (rs1801131) polymorphisms.
Results: Genotyping analysis of DPYD and MTHFR genes
polymorphism revealed the presence of one heterozygous
mutation in DPYD gene in 35% of our patient and MTHFR
c.1298CC homozygous genotype in 60% of our patients.
The presence of a variant in both genes occurred in 20% of
patients.
Conclusions: To date the oncologists have new means based
on the individual genetic composition, to make treatment
decisions maximizing benefits and minimizing toxicity.
Based on these purpose, clinician and lab manager may join
to evaluate advantages and limitations (costs and applicability) of the most appropriate methods to set up the best molecular diagnostic pharmacogenetic tests for 5-FU drugs. The
finding of our study confirms that MTHFR c.C1298T polymorphisms should be incorporated Into clinical practice to
enable a better individualization of optimized therapy.

T08
THERAPEUTIC STRATEGIES IN
PATIENTS WITH BREAST OR OVARIAN
BRCA1/2 MUTATED CANCERS: ROLE
OF PARP-INHIBITORS AND INDIRECT
COMPARISON WITH PLATINUM. A
SYSTEMATIC REVIEW AND METAANALYSIS
Staropoli N.1, Ciliberto D.1, Labanca C.1, Siciliano M.A.1, Cucè M.1,
Arbitrio M.2, Luciano F.1, Federico S.1, Salvino A.1, Barbieri V.1,
Tassone P.3, Tagliaferri P.4
1
Medical Oncology Unit Department of Experimental and Clinical Medicine,
Magna Græcia University and Cancer Center, Campus Salvatore Venuta,
Catanzaro, Italy, Catanzaro; 2CNR-Institute for Biomedical Research and
Innovation, 88100 Catanzaro, Italy, Catanzaro; 3Translational Medical
Oncology Unit Department of Experimental and Clinical Medicine, Magna
Græcia University and Cancer Center, Campus Salvatore Venuta, Catanzaro;
4
Medical Oncology Unit Department of Experimental and Clinical Medicine,
Magna Græcia University and Cancer Center, Campus Salvatore Venuta,
Catanzaro

Background: Poly (ADP-ribose) polymerase inhibitors
(PARPis) take advantage from defects in Homologous
Recombination (HR) pathways induced by germline BRCA
mutations through synthetic lethality. Several trials showed
anticancer activity in this selected population. About 25% of
hereditary breast cancers and 10% of ovarian cancers are
related to BRCA-1/2 mutations. Olaparib and Talazoparib
have been recently approved as monotherapy in HER-2
negative metastatic breast cancer (MBC). About 40% of



Tumori Journal Abstract Book - October 2020

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Tumori Journal Abstract Book - October 2020 - Cover1
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Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
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