Tumori Journal Abstract Book - October 2020 - 178

178	

Tumori Journal 106(2S)

Results: We identify functional inactivation E-cadherin, as
directed by Trop-2, as a pivotal driver of metastatic diffusion in human cancer. Binding to Trop-2 causes release of
E-cadherin from the cytoskeleton, loss of cell-cell adhesion
and activation of β-catenin. This leads to increased cell
migration and enhanced cancer cell survival. This global,
Trop-2/E-cadherin/β-catenin-driven pro-metastatic program was recapitulated in human cancer, and was shown to
profoundly impact on breast, colon, uterus, ovary, stomach,
lung, pancreas cancer metastatic diffusion.
Conclusions: We identify Trop-2-driven functional inactivation of E-cadherin as a shared driver of metastatic diffusion in
human cancer. A Trop-2/E-cadherin/b-catenin-led pro-metastatic program was shown to profoundly impact on the survival of patients bearing breast, colon, uterus, ovary, stomach,
lung, pancreas tumours, opening novel avenues for personalized diagnostic procedures and anti-cancer therapies.

T05
Thromboembolic events in cancer
patients treated with immune
checkpoint inhibitors: data from
retrospective and prospective
studies
Solinas C.1, Saba L.2, Sganzerla P.3, Petrelli F.4
1

2

Oncology Department, ATS Sardegna, Ozieri; Department of Radiology,
University of Cagliari, Monserrato; 3Cardiology Unit, ASST Bergamo Ovest,
Treviglio (BG); 4Oncology Unit, ASST Bergamo Ovest, Treviglio (BG)

Background: The overall risk of thromboembolism
(either venous and arterial) has not yet been estimated in
cancer patients treated with immune checkpoint inhibitors
(ICIs). We conduced a systematic review to evaluate the
incidence of venous and arterial thromboembolic events
(VTEs and ATEs) in patients treated with ICIs, as single
agents or in combination with other treatments.
Patients and Methods: Retrospective and prospective studies (identified from Pubmed, EMBASE, SCOPUS and The
Cochrane Library) reporting on the frequence of VTEs or
ATEs were eligible for this study, if they provided the number (or rate) of events and the size of the population included.
Efficacy results had to be published in English in peerreviewed journals or presented in proffered paper sessions of
major annual meetings. PRISMA guidelines were followed.
Data extraction was performed by two independent investigators (CS and FP), and discordant evaluations were discussed with a third independent observer (LS). The outcome
data extracted for each arm were analyzed using randomeffects models and were reported as weighted measures.
Results: 20,273 patients from 68 studies were included in
the present analysis. VTEs equaled to N=390, whereas
ATEs to N=59, with incidence rates (representing the preplanned primary study outcome) of 2.7% (95%CI 1.8-4%)

and 1.1% (95%CI 0.5-2.1%), respectively. Most ot these
events were associated with treatment with anti-PD-1 or
anti-PD-L1 agents. When ICIs were used as single agents
the incidence of VTEs was 2.3% (95%CI 1.3-4%). The rate
of pulmonary embolism was 1.6% (95%CI 0.7-3.2%)
whereas that of deep venous thrombosis was 2.7% (95%CI
1.4-5.4%). Rates of stroke and myocardial infarction were
1.1% and 0.7%, respectively, whereas fatalities due to VTEs
and ATEs equaled to 0.02% and 0.1%, respectively.
Conclusions: ICIs-associated VTEs and ATEs were
detected and not-negligible, particularly in patients with
advanced solid tumors. Future research should address
their prospective assessment, the evaluation of risk factors
and their prevention.

T06
HPV infection as the
interpretation key to understand
the prognostic role of
eosinophils in Anal Squamous Cell
cancer and Head and Neck cancer
Rimini M.1, Franco P.2, De Bari B.3, Andrikou K.4, Napolitano M.1,
Zampino M.G.5, Vagge S.6, Laffi A.5, Bacigalupo A.6, Gervaso L.5,
Tramontano D.7, Bertolini F.1, Cascinu S.8, Casadei A.1
1

Dipartimento di Oncologia - Ospedale Policlinico di Modena, Modena;
Dipartimenti di Radioterapia - Università di Torino, Torino; 3Dipartimenti di
Radioterapia - CHRU Besancon, Besancon; 4Istituto Scientifico Romagnolo
per lo Studio e la Cura dei Tumori (IRST) IRCSS, Meldola; 5Oncologia Medica
Gastrointestinale e Tumori Neuroendocrini - Istituto Europeo di Oncologia,
Milano; 6Radioterapia Oncologica - Ospedale San Martino, Genova; 7Health
Science Department (DISSAL), Genova; 8IRCSS Ospedale San Raffaele, Milano

2

Background: Anal SCC is a rare tumor associated with
the HPV infection. The gold standard is represented by the
CT-RT according to the Nigro scheme, but adequate bioumoral predictors of response are lacking. In order to find
new biomarkers, and to deepen the significance of the
HPV infection, we investigated the role of peripheral
eosinophil count in both anal SCCs and HNCs.
Methods: We retrieved clinical and laboratory data regarding patients affected by anal SCCs treated with concomitant CT-RT according the Nigro scheme from 5 oncologic
institutions. In parallel, we retrieved clinical and laboratory data regarding patients affected by HNCs with a confirmed diagnosis of SCC and treated with concomitant
CT-RT from 2 oncologic institutions. We examined the
association between baseline eosinophil count and DFS in
both the group of patients. We performed ROC-curve analysis to define the best eosinophil cut-off for our analysis
(100 10^9/L). Unadjusted and adjusted hazard ratios by
baseline characteristics were calculated using the Cox proportional hazards model.
Results: 304 consecutive patients with anal SCCs and 168
patients with HNCs, 122 (72.6%) HPV-positive and 46



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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