Tumori Journal Abstract Book - October 2020 - 173

S - Management of Cancer Pain	

173

S11

S12

NSAIDs efficacy and physical
compatibility of ketoprofen in
drug mixtures used intravenously
in an inpatient hospice ward

Simultaneous home cancer
treatment in the Provincial
Health Authority of Vibo Valentia

1

2

3

3

2

Gabrielli G.1, Spinoso A.1, Grillone F.1, DeCarlo M.1, Arena M.1
2

Ricci M. , Maltoni M. , Galetti A. , Vaca G. , Fabbri L. , Sansoni E. ,
Bedini A.3
1

IRCCS IRST Meldola, Meldola; 2Hospice Valerio Grassi, Forlimpopoli;
Dipartimento di Farmacia e Biotecnologia Università di Bologna, Bologna

3

Background: The NSAIDs use in our hospice was retrospectively evaluated in terms of prevalence, modality of
administration and clinical outcomes; furthermore, the
nonsteroidal anti-inflammatory drug most frequently used
in our hospice (ketoprofen) was tested in combination with
other drugs to assess its physical compatibility.
Material and Methods: We analyzed the medical
records of 185 patients with hematologic malignancies
or solid tumors consecutively admitted to our hospice
from January 1st to September 30th, collecting data on
patient characteristics, type of tumor, ongoing and
administered therapies, including analgesics and
NSAIDs. We also evaluated the physical compatibility
of a binary mixture of ketoprofen and morphine and of
eight ternary mixtures of ketoprofen, morphine and a
third drug (midazolam, haloperidol, metoclopramide,
chlorpromazine, furosemide, diazepam, hyoscine butylbromide or dexamethasone) at baseline (0) and 1, 5, 24,
48, 96 and 168 hours after preparation. Single-drug
preparations of morphine and ketoprofen, diluted in
0.9% NaCl aqueous solution, were set up as controls.
The physical compatibility of the mixtures was tested
by visual inspection of the mixtures against black and
white backgrounds. The pH of the solutions was determined by a calibrated digital pH meter and spectrophotometric absorbance between 400 and 700 nm was
measured by a Jasco V-530 spectrophotometer.
Results: The binary mixture containing ketoprofen and
morphine did not show important alterations in pH or
spectrophotometric absorbance between 400 and 700 nm
at any of the considered time points. The most problematic
ternary mixture was that comprising ketoprofen, morphine
and chlorpromazine, in which significant changes in color,
turbidity and spectrometric absorbance occurred immediately after preparation. From the retrospective analysis we
found that the ketoprofen- morphine binary mixture given
on demand resolved 94% of 362 episodes of breakthrough
pain, without side-effects.
Conclusions: The binary mixture of ketoprofen and morphine was compatible and no alterations assessable with
physical methods were observed. Moreover, it proved safe
and highly effective in managing episodes of breakthrough
pain in cancer patients.

1

Azienda Sanitaria Provinciale di Vibo Valentia, Tropea (VV)

Background: Oral, intramuscular, subcutaneous and topical applications, thanks to their manageability, can be
administered easily at home. The oncologist specialist
must always collaborate with various socio-health realities
which have had or are in charge of the home patient.
Material (patients) and methods: From January 2011 to
December 2019: 412 patients with advanced (locally and
metastatic) neoplastic diseases. The median age was 68
years; the males was 54%. The oncological pathologies
were: Lung cancer (NSCl and SCL) 18.4% Colon-rectum
cancer 15.9% Liver, pancreas and biliary tract cancer
12.1% Prostate, bladder and kidney cancer 11.5% Breast
cancer 9.6% Hematological malignancies (myelomas, leukemia ...) 6.2% Gastric cancer 5.0% Head-neck cancer
4.4% Gynecological cancers 3.7% Brain tumor 3.4% Skin
cancers 3.4% Malignancies undeterminable 3,4% Other
malignancies 2.2%.
The patients considered fit to receive specific home cancer
treatment were 81 (22% of the total). The drugs used are
classifiable from the point of view of the mechanism of
action as drugs: - chemotherapy; - organic; - hormonal;
- immunological.
The list of drugs used is listed in alphabetical order:
1Abiraterone 2Anastrazole 3Bicalutamide 4Capecitabine
5Cyclophosphamide
6Chlorambucil
7Denosumab
8Enzalutamide 9Erlotinib 10Estramustine 11Exemestane
12Fulvestrant 13Idealsidib 14Hydroxyurea 15Imiquimod
16Lenalidomide 17Letrozole 18Lapatinib 19Leuprorelin
20Medroxyiprogesterone acetate 21Megestrol acetate
22Prednisone 23Regorafenib 24Sorafenib 25Tamoxifen
26Temozolomide 27Trifluridine tipiracil 28Triptorelin
29Vinorelbine 30Vismodegib.
Results: The treatment carried out, in the majority of
cases, has shown its efficacy from a symptomatic or laboratory point of view.
Conclusions: Home-specific medical cancer treatment
has proven practicable in many patients with adequate PS.

S13
Denial and early simultaneous
palliative care in the era of
prevention
Rondini M.1, Olivieri E.2, Bormolini G.3, Aschele C.4, Ceglie R.2,
Bregnocchi M.5



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
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Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
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Tumori Journal Abstract Book - October 2020 - Cover3
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