Tumori Journal Abstract Book - October 2020 - 172

172	

Tumori Journal 106(2S)

S09

S10

Local treatment with
deep percutaneous
electrochemotherapy of various
tumor lesions: cancer pain relief
and objective response results
from an observational study

PENALTY FOR SIMULTANEOUS CARE
DURING THE EMERGENCY COVID-19

Laface C.1, Gadaleta C.D.1, Fazio V.1, De Ceglia D.1, Macina F.1,
Gisone V.1, Porcelli M.1, Vinciarelli G.1, Carella C.1, Molinari P.1,
Laricchia G.1, Laforgia M.2, Ranieri G.1
1

Interventional and Medical Oncology Unit, IRCCS Istituto Tumori "G. Paolo
II", Bari, Italy; 2Pharmacology Unit, IRCCS Istituto Tumori "G. Paolo II",
Bari, Italy

Background: Electrochemotherapy (ECT) is a non-thermal technique that has proved to be safe and effective
against many types of solid tumors. ECT effectiveness and
safety in the treatment of various cutaneous tumors have
been extended in the treatment of deep-seated tumors. The
aim of this investigation focuses on the evaluation of the
efficacy of deep percutaneous ECT in terms of cancer pain
relief and local objective response, in pre-treated patients
with neither further available pharmacological treatments
nor eligible for surgery.
Materials and Methods: Deep Percutaneous ECT has
been performed in 20 patients subjected to systemic anaesthesia. Bleomycin was administrated intravenously before
the application of the electrical pulses on the target area,
employing multiple single needles depending on the size
and location of the target tumor.
Results: Pain assessment based on Visual Analogue Scale
showed significant pain relief one month after treatment in
all patients, reducing from 7,5 to 3 as a median value
(p-value at Wilcoxon test <0.001). Local symptom-free
survival median value was 5.5 months. At the first followup (1-2 months), a local disease control rate (LDCR) was
observed in 19/20 (95%) patients: complete responses in 2
(10%), partial responses in 8 (40%) and stable disease in 9
(45%). Local progression-free survival median value was
5.7 months. Overall, no major adverse effects were observed.
Conclusions: Our study confirms that deep percutaneous
ECT can produce a significant cancer pain reduction and
a high LDCR in different tumor lesions, for anatomical
site or histotype. In particular, ECT has demonstrated to
be effective in various histotypes and deep-seated tumor
lesions never treated before by this approach and giving
a new chance to physicians to manage cancer pain in
patients not eligible to other therapeutic routes. In addition, our study was the first successful application of
deep percutaneous ECT on adrenal metastasis, malignant
pleural mesothelioma, uterine leiomyosarcoma and the
exceptional case of a male müllerian tumor.

Antoniazzi F.1, Pastorini A.2, Fusco O.2, Cubeddu A.2, Maiolani M.2,
Caponigro G.2, Deligiannis P.2, Cantini S.2, Menatti E.2, Fregoni V.3,
Geronimi C.4, De Carlo A.4, Pedrotti C.1, Bagassi A.4, Bertolini A.5
1

ASST della Valtellina e Alto Lario-Cure Palliative, Sondalo; 2ASST della
Valtellina e Alto Lario-Oncologia Medica, Sondrio; 3ASST della Valtellina e Alto
Lario-Medicina Generale, Sondalo; 4ASST della Valtellina e Alto Lario-Cure
Palliative, Morbegno; 5ASST della Valtellina e Alto Lario-Cure Palliative, Sondrio

Background: Simultaneous care represents an organizational model based on the global care of the cancer patient
through continuous assistance and a progressive integration between cancer therapies and palliative care. The
model responds to global needs (physical, psychological,
social) of the patient and his family managed by a multidisciplinary team made up of oncologists, palliativists,
radiotherapists, psychologists. As compared with cancer
patients receiving standard care, patients receiving early
palliative care had less aggressive care at the end of life
and longer survival. In the province of Sondrio ASST
Valtellina and Alto Lario has activated simultaneous care
for cancer patients for about a year.
Material (patients) and methods: The simultaneous
care clinics are structured on defined days and times,
managed by a multidisciplinary team which always
involve family members. During the emergency period
the surgeries underwent changes in terms of organization
and frequency. The reduction in the number of doctors
available and the limitations of patient access to hospital
clinics for their protection have led to a significant reduction in the numbers of cancer patients treated early in
simultaneous treatment. The analysis of the data defines
a number of 12 cancer patients followed simultaneously
in a pre-covid period from 1 November 2019 to 31
January 2020. During the covid-19 emergency, in the
period from 1 March 2020 to 31 May 2020, they were
followed 5 patients. On average 3 patients versus 1 in the
emergency period.
Results: During the covid-19 emergency, the results show
a significant reduction in simultaneous care paths. In this
phase, the simultaneous care clinic was managed as needed
by a single professional with telephone consultations and
few home visits without the direct involvement of family
members.
Conclusions: The reduction in simulataneous care during
the emergency period penalized cancer patients who, in a
moment of clinical fragility, experienced a lived experience of abandonment that affected their quality of life.
In memory of dr. Fabio Rubino, Responsible for the
Palliative Care Service.



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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Tumori Journal Abstract Book - October 2020 - Cover3
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