Tumori Journal Abstract Book - October 2020 - 165

P - Brain Tumours	
Kaplan-Meier was applied to estimate overall survival
(OS) and the difference between the groups were compared
with log-rank test.
Results: A total of 40 pts have been analysed, median age
was 66 years (range 25-84), 50% of pts had MGMT methylation and 7.5% had IDH1/2 mutations. Approximately
half of pts (56%) had EGFR mutation and the majority
(90%) had TERT mutation. MET expression (score =1)
was expressed in 57.5% of pts. In particular, scores 0, 1, 2
and 3 were found in 42.5%, 30%, 17.5% and 10% of the
cases, respectively. Median OS for the entire population
was 12.1 months (mo) (95%CI 7.8-15), with a median OS
of 14 mo (95%CI 5.6-21.6) for MET-negative pts (score 0)
and only 7 mo (95%CI 1.9-NR) for pts with high-METexpression (score 3), HR 3.9; 95%CI 1.2-13; p 0.024. In a
multivariable cox-regression analysis high-MET-expression remains as an independent negative prognostic factor
also considering MGMT and IDH1/2 status (HR 3.2;
95%CI 0.95-11; p = 0.060). Interestingly, EGFR WT
seems to be associated to a MET positive staining (score
=1) in 75% of cases (p 0.049).
Conclusions: Our findings confirmed the negative prognostic role of an high-expression of MET in GBM (10% of
the cases in our study). Further studies are awaited to
assess the role of eventual MET inhibitors in GBM cases
expressing this target.

P06
Financial status impacts overall
survival in glioblastoma: a
prospective clinical trial
Gatto L.1, Tosoni A.1, Franceschi E.1, Di Nunno V.1, Minichillo S.1,
Mura A.1, Di Battista M.1, Lamperini C.1, Mosca M.1, Nuvola G.1, Sisi
M.1, Bartolini S.1, Brandes A.A.1
1
Department of Medical Oncology, Azienda USL/IRCCS Institute of
Neurological Sciences, Bologna

Background: There is some evidence that the socioeconomic status (SES) is associated with survival in glioblastoma (GBM), but the findings are limited.
We conducted a single centre prospective observational
study investigating the association between SES and GBM
survival in Italy, where exists a national health service that
provides universal coverage.
Materials and methods: This study was a prospective
analysis of newly diagnosed GBM patients who underwent chemoradiation between 2018 and 2020 in a hub
center for brain cancer research. The SES was measured
using the income-brackets, extracted from regional health
administrative system.
The income-brackets refer to annual gross family income:
up to 36,152 euros in income is classified as R1 bracket;
between 36,153 and 70,000 euros as R2; between 70,0001
and 100,000 euros as R3; over 100,000 euros as R4.

165
Results: One hundred six patients were included in the
study. In multivariable cox proportional hazard model of
survival, a high available income was associated with
improved survival HR= 0.623 (95%CI 0.467-0.832; p =
0.001). When adjusted for age, survival remained improved
for high-income patients.
Conclusions: We confirm that SES is an important determinant of prognosis in GBM even in the Italian National
Health Service which provide universal, largely free and
relatively comprehensive healthcare. Despite aspirations
to achieve equality in healthcare, socioeconomic differences exist and may impact on clinical outcome.

P07
Should be used BEVACIZUMAB in
RECURRENT GBM? A metanalysis
Tiberi E.1, Urbini B.1, Mauro E.1, Fasano A.1, Cecchetto C.1, Toma I.1,
Lancia F.1, Martella L.R.1, Frassoldati A.1
1

Azienda Ospedaliero-Universitaria Sant'Anna Ferrara, Ferrara

Background: GBM is the most common and most aggressive primary brain tumor in adults. The 1 year-OS is almost
35%. The recurrences often are in the nearby of the primary tumor (2/3 of all cases): if the surgery is not indicated, which one is the best second-line treatment?
Nitrosourea chemotherapy is the common choice without
a significant increasing in OS and PFS versus placebo.
FDA approved the use of Bevacizumab in this setting but
the clinical trials show different results in terms of OS and
PFS. The aim of this metanalysis is to evaluate the efficacy
of bevacizumab alone or in combination with standard
chemotherapy in the treatment of recurrence GBM.
Material (patients) and methods: It was take into consideration only randomized trails comparing the use of bevacizumab alone or in combination with CHT versus standard
chemotherapy in recurrent GBM. A systematic rewiew of
this trials using Pubmed was performed. Cochrane Risk of
Bias Tool was used to quantify the between-study eterogeneity risk of bias and a random effect model was used to
evaluate OS and PFS.
Results: Four randomized phase II-III trials have been
selected among 106 Pubmed citations: -two trials : bevacizumab alone in the experimental arm - two trials : combo
bevacizumab-chemotherapy in the experimental arm
Nitrosourea chemotherapy (lomustine or fotemustine) was
used in the control arm and in association with bevacizumab. A total of 668 patients were analized. The metaanalyses showed a statistically significant benefit of
bevacizumab in terms of PFS (cumulative HR=0,52,IC
95% 0,39-0,60,p<0.0001, Q= 2,21, df= 3,I2= 0%, for the
combination chemotherapy-bevacizumab HR =0.48, IC
95% 0.39-0.60, p <0.0001, Q=0,3 DF=1, I2=0%) but not
in term of OS (HR=0,95, 95% IC 0,77-1,17, P=0,63,
Q=1,53,df=3, I2=0%).



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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