Tumori Journal Abstract Book - October 2020 - 158

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Tumori Journal 106(2S)

the VS, 3y-DFS was 66% [52-85%] vs 91% [82-100%] and
OS was 88% [75-100%] vs 96% [88-100%], respectively.
Conclusions: In HNSCC, radiomics of b-MRI can help to
predict recurrence and survival outcomes.

Median (m) age (IQR)
Sex (%)
M
F
m-Smoking history,
packs/y (IQR)
Subsite (%)
Oral cavity
Oropharynx
HPV+
Larynx
Hypopharynx
m-FUP, months (IQR)
Status (%)
Alive
Dead
Recurrence (%)
Locoregional
Distant

TS (N=57)

VS (N=72)

67 (38-86)

63 (32-87)

47 (82%)
10 (18%)
30 (1-100)

55 (76%)
17 (24%)
33 (3-125)

26 (46%)
23 (39%)
15 (65%)
6 (11%)
2 (4%)
40,5(7-76)

36 (50%)
25 (35%)
15 (60%)
5 (7%)
6 (8%)
40(8-62)

51 (90%)
6 (10%)
11 (19%)
9 (82%)
2 (18%)

58 (81%)
14 (19%)
17 (24%)
10 (59%)
7 (41%)

HNSCC patients in order to better select prone to respond
to immunotherapy.
Methods: Patients (pts) treated with Nivolumab were
enrollerd. The patients blood samples were collected at the
baseline (T0). The immune profile was studied by multiplex assay, evaluating sIC: CD137, CTLA4, PD1, PDL1,
PDL2, CD27, Tim3, Lag3, GITR, HVEM and BTLA. The
association between baseline circulating levels of sIC and
early progression (within 3 months from the start of
nivolumab) was investigated.
Results: Thirteen pts with platinum refractory R/M
HNSCC were enrolled. Median age was 65 (46-81), 8 pts
were men. Early progression occurred in 7 pts (53.8%); 5
pts (38.4%) were alive at 6 months. Median progression
free survival and median overall survival were 3 months
(1-11) and 5 months (2-11), respectively. CD137, CTLA4,
PD1, PDL1, PDL2, Tim3, Lag3, GITR, HVEM, and
BTLA were evaluated at T0 and the median value for each
sIC was defined. In 7 pts (53.8%), 5 or more sIC were
higher than the median value, while in 6 pts (46.2%) less
than 5 sIC were higher; the detection of lower baseline
levels of sIC were significantly associated with early progression (p=0.04).
Conclusions: High baseline circulating levels of soluble
checkpoints may indicate an effective immune system activation. Conversely, lower levels of sIC could suggest an
"immune dormancy profile" in HNSCC patients. A larger
sample size is needed to confirm these preliminary results.

N03
Soluble immune checkpoints in
head and neck cancer patients
treated with nivolumab: a pilot
study
Botticelli A.1, Mezi S.2, Pomati G.2, Zizzari I.G.3, Cerbelli B.2, Cirillo
A.2, Mammone G.2, Di Filippo A.3, Scirocchi F.3, Pellegrino D.2, Della
Rocca C.4, Polimeni A.5, Nuti M.3, Marchetti P.6
1

Sapienza Università di Roma, Dipatimento di Medicina Clinica e
Molecolare, Roma; 2Sapienza Università di Roma, Dipartimento di
Scienze Radiologiche, Oncologiche ed Anatomo Patologiche, Roma;
3
Sapienza Università di Roma, Dipartimento di Medicina Sperimentale,
Roma; 4Sapienza Università di Roma, Dipartimento di Scienze e
Biotecnologie Medico-Chirurgiche, Roma; 5Sapienza Università di Roma,
Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali, Roma;
6
Sapienza Università di Roma, Dipartimento di Medicina Clinica e
Molecolare, Roma

Background: The anti-programmed death-1 (PD-1) agent
nivolumab is the standard of care in platinum refractory
recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, only a small subset of
patients really benefit from immunoherapy, suggesting the
need of novel predictive biomarkers of response or resistance. Soluble immune checkpoints (sIC) represent a novel
and intriguing field of research. The aim of this study was
to investigate a novel circulating immune profile of

N04
Cytokines and interleukins
performance during nivolumab
treatment. A subgroup analysis of
NIVACTOR study
Falletta A.1, Paccagnella M.1, Denaro N.2, Abbona A.1, Galizia D.3,
Fiorino E.3, Gammaitoni L.3, Sangiolo D.3, De Zarlo L.3, Merlano M.2
1

Department of Traslational Oncology, Ospedale S.Croce e Carle Cuneo,
Cuneo; 2Ospedale S.Croce e Carle Cuneo, Cuneo; 3IRCCS Candiolo Institute,
Turin, Torino

Background: Recurrent or Metastatic Platinum-refractory
Squamous Cell Carcinoma of the Head and Neck (R-M
SCCHN) is a major clinical issue with 1 year survival rate
of 20-30% and a median OS of 10 months. Nivolumab,
anti-PD1 mAb, is approved for 2nd line R-M HNC, but
only 15-20% of patients will benefit.
Patients and methods: Aim of the study was to analyze
the changes of a panel of 17 circulating cytokines and
interleukins during nivolumab treatment at baseline (T0),
at day 1 cycle 3 (T1), at day 1 cycle 7 (T2) and at disease
progression (PD), (T3). Cytokines' concentrations were
assessed in plasma samples using the Simple Plexsystem
(ProteinSimple, San Jose, CA, USA). Basal values and



Tumori Journal Abstract Book - October 2020

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Contents
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Tumori Journal Abstract Book - October 2020 - Contents
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Tumori Journal Abstract Book - October 2020 - Cover3
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