Tumori Journal Abstract Book - October 2020 - 15

A - Thoracic Cancers	
stage III unresectable NSCLC patients in the Italian realword scenario.
Methods: A 15-questions survey focusing on the clinical
management of patients with stage III NSCLC was sent to
75 oncology/pathology centers specialized in the field of
thoracic malignancies across the different Italian regions.
Results: From January 15th to January 30th 2020, 45
responses (60%) were collected, with a total of 251 patients
receiving durvalumab therapy for stage III unresectable
NSCLC. The 63% of patients undergone previous concurrent chemoradiation, with carboplatin-paclitaxel and platinum-etoposide, emerging as the most common regimen
associated to radiotherapy in 61% and 39% of cases,
respectively. In almost all cases the expression level of
PD-L1 was assessed at the time of histological diagnosis
(pre-chemoradiation), upon request of medical oncologists. Consolidation therapy with Durvalumab was initiated between the 14th day and the 6th week, and between
the 6th and the 8th week from the last day of radiotherapy in
68% and 25% of cases, respectively. Among the 250
included patients, a significant subgroup discontinued durvalumab because of early disease progression (12%) or
high grade toxicities (8%) occurrence, while 27% of them
completed 1-year consolidation treatment, as established
by current guidelines. The remaining population was still
on treatment at the time of data collection. Finally, among
those patients who completed 1-year durvalumab consolidation, 7% experienced disease progression and all of
them were candidate to platinum-doublets chemotherapy.
Conclusions: This survey provides a reliable picture of the
current clinical management for unresectable stage III
NSCLC patients in the Italian real-word scenario, and
highlight the urgent need for post-durvalumab progression
treatment strategies in this setting.

A20
Correlation between toxicity and
response rates in NSCLC treated
with Nivolumab according to
neutrophil to lymphocytes
ratio (NLR) and platelets to
lymphocytes ratio (PLR)
Rossi L.1, Gozzi E.2, Raimondi L.2, D'Assisi Cardillo F.3, Verrico M.3,
Cimino G.4, Angelini F.5, Conte D.5, Lo Russo V.5, Tomao S.6

15
Patients and methods: We enrolled 75 patients (pts) ( 37
men and 38 women) with metastatic NSCLC treated with
Nivolumab after failure of first line chemotherapy.
Pre-treatment NLR and PLR were calculated by division
of neutrophils and platelets by lymphocytes measured in
peripheral blood.
Pts were divided into groups based on the NLR (NLR<3
and NLR ⩾3) and PLR value (PLR< 170 and PLR ⩾170).
We examined several immunorelated toxicities such as:
endocrine, hepatic, hematological, cardiovascular, hypertension, fever, fatigue, diarrhea/colitis, pneumonitis, dyspnea, myalgia, hypomagnesemia, oedema.
We correlated the number of toxicities found with treatment effectiveness according to NLR and PLR.
Response rate: complete response (RC), partial response
(RP), stable disease (SD), clinical benefit (CB) (RC+RP
+SD), progression disease (PD).
Results: All pts had toxicity grade (G)1,G2 and G3. We
did not observe toxicity G4.
Regarding NLR, 36 pts (48%) had high NLR and 39 (52%)
pts had low NLR.
At the first instrumental evaluation, 12 pts (33.3%) with
high NLR had CB and 24 pts (66.6%) had PD.
In pts with low NLR, 25 (64.1%) had CB and 14 ( 35.8%)
PD.
In subgroup with high NLR, pts with CB had an average
number of toxicity of 3.9 VS 5.5 in pts with PD.
In subgroup with low, pts with CB had an average number
of toxicity of 2.6, VS 4.9 in pts with PD.
Regarding PLR, 35 pts (46.6%) had high PLR and 40 pts
(53.3%) had low PLR.
10 pts (28.5%) with high PLR had CB while 25 pts (71.4%)
had PD.
27 pts (67.5%) with low PLR had CB and 13 pts (32.5%)
had PD.
In subgroup with high PLR, pts with CB had an average
number of toxicity of 3.4 VS 5.2 in pts with PD.
In subgroup with low PLR, pts with and CB had an average number of toxicity of 2.9, VS 5.5 in pts with PD.
Conclusions: Our study showed that in high NRL and
PRL there is a higher incidence of immuno-related toxicity
in patients with worse prognosis: they could be considered
prognostic and safety markers.

A21

1

Università Sapienza di Roma, Aprilia; 2Università la Sapienza di Roma,
Aprilia; 3ASL Latina, Formia; 4Università la Sapienza di Roma, Latina;
5
Ospedale Regina Apostolorum Albano laziale, Albano; 6Università la
Sapienza di Roma, Roma

Prognostic value and safety of
eosinophilia (EO) in non-small-cell
lung cancer (NSCLC) treated with
Nivolumab: our experience

Background: Elevated pre-treatment NLR and PLR are
associated with worse overall survival (OS) in several
tumors treated with immunotherapy.
The aim of our study was to correlate NLR and PLR to
response rates and safety of Nivolumab in NSCLC.

Colonna M.1, Gozzi E.2, Rossi L.2, Mannino A.2, Verrico M.3, Cimino
G.4, Tomao S.5
1

Ospedale Fiorini, Terracina; 2Università la Sapienza di Roma, Aprilia; 3ASL
Latina, Formia; 4Università la Sapienza di Roma, Latina; 5Università la
Sapienza di Roma, Roma



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
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Tumori Journal Abstract Book - October 2020 - Cover3
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