Tumori Journal Abstract Book - October 2020 - 149

H - Genitourinary Tumours	
Material and methods: Data from 133 pts with mRCC
treated at Modena Oncologic Center between 2006 and
2019 were collected. We defined as long-term survivors
(LTS) the pts with mOS ⩾36 mos, and as short-term survivors (STS) those with mOS ⩽12 mos from the date of
mRCC diagnosis. All pts received a 1st line therapy. A
Chi-square test was used to compare variables between
both groups. OS and progression-free survival (PFS) were
evaluated by the Kaplan-Meier method and log-rank test.
Results: The mOS of the whole population was 27 mos (CI
95% 19.57-34.42). 42 pts (31.5%) were LTS, and 44 (33%)
were STS. No significant differences in terms of median
age at mRCC diagnosis (around 64 years) and gender
(mainly males) were found between the two groups. Among
the LTS, 43% and 16.6% were classified according to Heng
score as good/poor risk pts, as compared to 13.6% and 34%
among the STS. 27 LTS pts (64.3%) had metachronous
metastases, while 31 STS (70.5%) had synchronous metastases. The most common metastatic sites at diagnosis were
lung, lymph nodes, and bone in both groups, whereas liver
metastases were observed in 7% of LTS and 34% of STS
pts. mOS was 61 (CI 95% 31.14-90.86) and 7 mos (CI 95%
5.56-8.44), in the two groups. Median PFS (mPFS) for 1st
line therapy was 24.5 and 3 mos, respectively, with a
remarkably higher disease-control rate (DCR) for LTS
(88% vs 34%). Furthermore, 83.3% of LTS pts received
2nd line therapy with a mPFS of 8 mos, while only 41% of
STS pts underwent a 2nd line therapy with a mPFS of 1.5
mos. Comparing the two groups, metachronous disease
(p=0.001), absence of liver metastases at the diagnosis of
metastatic disease (p=0.002), and Heng good risk (p=0.003)
emerged as associated with long survival.
Conclusions: According to literature, our series shows a
favorable prognostic role for metachronous disease,
absence of liver metastases, and good risk score in pts with
mRCC. However, further investigations are needed to better understand the biological and molecular mechanisms
underlying the observed differences between the two
populations.

H23
Effect of Obesity on Overall
Survival in Patients with
metastatic Prostate Cancer: A
Retrospective Institutional Study
Vitale M.G.1, Cerma K.1, Baldessari C.1, Fanelli M.1, Caputo F.1, Riggi
L.1, Bardasi C.1, Pipitone S.1, Dominici M.1, Sabbatini R.1
1

University Hospital of Modena, Division of Oncology, Modena, Modena

Background: Prostate cancer is the second most frequent
tumour among males in Western countries. Recent evidences suggest that elevated Body Mass index (BMI) is
associated with aggressive disease and a higher risk of

149
recurrence in prostate cancer patients (pts). We aimed to
evaluate the association between BMI and overall survival
(OS) in patients with metastatic prostate cancer (mPC).
Material and Methods: This retrospective study included
189 mPC pts diagnosed between 2003 and 2019 in Modena
Cancer Centre and categorised according to BMI (normal/
low BMI <25 kg/m2 and high BMI ⩾25 kg/m2) calculated
from height and weight extracted from medical records at
the time of mPC diagnosis. Overall survival (OS) curves
were drawn using the Kaplan-Meier method and long rank
test was used to compare OS within BMI groups.
Results: The median OS of the whole group was 47,7
months (mo) (95%CI, 42,8-190,9). 121 (64%) pts had a
high BMI. The median age of pts in high and normal/low
BMI group at baseline was 72 and 74 years, respectively. At
diagnosis there were no significant differences between the
two groups regarding stage, T classification, age (<75 vs
⩾75 years), bone, lymph-node and liver metastasis. Among
pts with high BMI, a higher Gleason Score (⩾8: 64,7% vs
49,2%, p=0,043) and less lung metastasis (presence: 3,1%
vs 15,4%, p=0,006) were evidenced. No significant differences were noted between the two groups regarding
response to I line of treatment (progressive disease vs complete response, partial response or stable disease), toxicities
of I line treatment and number of lines of therapy received
(<3 vs ⩾3). Pts with higher BMI had better OS (median OS
58,4 mo, 95%CI, 43,0-78,6) than patients with normal/low
BMI (39,8 mo, 95%CI, 32,1-190,9), but difference did not
reach statistical significance (p=0,102).
Conclusions: BMI is not associated with statistically significant differences in overall survival in patients with
mPC treated with new drugs. Larger studies are needed to
confirm these findings.

H24
Efficacy and safety of nivolumab
after sunitinib or pazopanib:
retrospective analysis of a case
series from oncology centers of
North-Western Tuscany
Sbrana A.1, Paolieri F.1, Bloise F.1, Sammarco E.1, Nuzzo A.1,
Manacorda S.1, Bazzurri S.1, Manfredi F.1, Mercinelli C.1, Biasco E.2,
Farnesi A.3, Caparello C.4, Pacetti P.5, Antonuzzo A.6, Dargenio F.4,
Falcone A.1, Galli L.1
1

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina
e Chirurgia, Università di Pisa, Pisa; 2Dipartimento Oncologico, Azienda USL
Toscana Nord Ovest, Portoferraio (LI); 3Dipartimento Oncologico, Azienda USL
Toscana Nord Ovest, Livorno; 4Dipartimento Oncologico, Azienda USL Toscana
Nord Ovest, Piombino (LI); 5Dipartimento Oncologico, Azienda USL Toscana
Nord Ovest, Massa-Carrara; 6Azienda Ospedaliero-Universitaria Pisana, Pisa

Background: A subgroup analysis of the CheckMate 025
trial, a phase III trial of nivolumab (NIVO) versus everolimus in second-line metastatic renal cell carcinoma (mRCC),



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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