Tumori Journal Abstract Book - October 2020 - 147

H - Genitourinary Tumours	

147

group. mOS was not reached in the general population and
in the IR group, whilst it was 7.93 mos (95%CI 2.23-7.93)
in the PR group. At the regression analysis we observed a
statistically significant correlation between baseline CRP
levels (r2 = 0.4028, p = 0.0148), neutrophil-to-lymphocyte ratio (NLR) (r2 = 0.2979, p = 0.0435), platelet-tolymphocyte ratio (PLR) (r2 = 0.3143, p = 0.037) and OS.
We also found a correlation between baseline ESR and OS,
though not statistically significant (r2 = 0.2334, p =
0.0801). No further correlation between other laboratory
parameters and OS was found.
Conclusions: NIVO plus IPI is highly effective in IR and
PR mRCC pts, but there are still some pts who do not benefit from this treatment. The research of new baseline predictive biomarkers is then a main goal for medical
oncologists. In our little experience, lower values of baseline CRP, NLR, and PLR seem to be correlated with a better clinical outcome. However, further investigations in a
wider number of patients are needed in order to prospectively validate our findings.

H19
Invasive urothelial carcinoma
and neural phenotype:
alternative score detection
(Piescore) and prognostic
implications
1

2

2

3

for IHC analysis, using relevant gene-expression-based
markers for Luminal type (CK20 and pPARg) and Basal
type (CD44, CK5/6). The Piescore divided Basal and
Luminal types when at least 3 of the 4 markers were consistent with a specific phenotype; Mixed if two luminal and two
basal markers were present simultaneously; NE-like when
all four markers were negative.
Results: Overall, the Piescore identified Basal phenotypes in
77 pts (45%), Luminal in 52 (30%), Mixed in 13 (8%), and
NE-like in 31 (18%). Among NE-like phenotypes, 6 cases
presented morphological NE differentiation and 25 urothelial differentiation. With a median FU of 97.1 months, pathological stage of disease (pT2 versus ⩾pT3 and/or N+) and
vascular invasion (absent vs present) resulted prognostic
(Stage: 5-years DFS rate 50.7% vs 26.8%, p=0.008; 5-years
OS rate 64.8% vs 38.2%, p=0.04) (vascular invasion: 5-years
DFS rate 42.5% vs 16.6%, p<0.0001; 5-years OS rate 56.3%
vs 25.2%, p<0.001) in all population. No statistically significant differences in terms of pathological stage of disease,
vascular invasion, DFS, and OS were observed in NE-like
cases compared with non-NE-like cases.
Conclusions: The NE-like urothelial carcinoma identified
by Piescore immunophenotyping NE-like did not show
any statistically significant association with prognosis.

H20
2

Zucali P.A. , Colombo P. , De Carlo C. , Giordano L. , Ciceri M. ,
Hurle R.4, Lazzeri M.4, Elefante G.M.4, D'antonio F.5, Perrino M.5,
De Vincenzo F.5, Guazzoni G.4, Roncalli M.2, Santoro A.3
1

Department of Oncology, Humanitas Clinical and Research Center, IRCCS,
Rozzano (Milano); 2Unit of Pathology, Humanitas Clinical and Research
Center, IRCCS, Rozzano, Milano; 3Departement of Oncology, Humanitas
Clinical and Research Center, IRCCS, Rozzano, Milano; 4Deprtement of
Urology, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milano;
5
Deprtement of Oncology, Humanitas Clinical and Research Center, IRCCS,
Rozzano, Milano

Background: Several molecular subtyping studies (NGS)
identified a subset (5-15%) of muscle invasive urothelial
carcinoma (MIBC) with transcriptomic patterns consistent
with neuroendocrine (NE) differentiation in the absence of
NE histology (NE-like). It represents a potentially high
risk subgroup of carcinoma which may require a different
treatment strategy. In order to discriminate Luminal from
Basal from Neural carcinoma, we set an alternative
immuno-phenotypical score (Piescore). Aim of this study
is to test the ability of Piescore in identifying NE-like cases
in a mono-institutional cohort of patients (pts) treated with
trans-urethral resection and radical cystectomy (RC) and
to correlate them with clinical outcomes.
Methods: Transurethral resection specimens harbored foci
of high grade pT2 (MIBC) urothelial carcinoma from 173
pts who subsequently underwent RC have been submitted

Clinical and Pathological
features of elderly patients with
metastatic Renal Cell Carcinoma
(mRCC): a monocentric experience
Bardasi C.1, Caputo F.1, Baldessari C.1, Vitale M.P.1, Fanelli M.1,
Cerma K.1, Riggi M.L.1, Pipitone S.1, Dominici M.1, Sabbatini R.1
1

Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena

Background: Although more than 60% of metastatic renal
cell carcinoma (mRCC) occurs in patients (pts) older than
60 years (y) and 20% in those older than 75y, elderly pts
are often excluded or under-represented in clinical trials.
The management of this mRCC subpopulation is not
standardized, although age should not be considered a barrier to effective treatment, especially after the introduction
of novel therapies. In this retrospective and monocentric
study, we evaluated the disease characteristics of elderly
pts (⩾ 75y) comparing with youngers (< 75y).
Material and Methods: 133 pts with mRCC treated at
University Hospital of Modena between 2006 and 2019 were
analyzed. Statistical analysis was performed using χ2 test,
Kaplan-Meier method and log-rank test. Overall survival
(OS) was calculated from the date of metastatic disease.
Results: Median age at diagnosis was 65 y. 28 pts (21%)
were ⩾ 75y while 105 pts (79%) were < 75y. No difference was revealed in terms of gender (male vs female,
p=0,760), T stage (T1-2 vs T3-4, p=0,381), metastasis at



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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