Tumori Journal Abstract Book - October 2020 - 146

146	
TRAE were reported in 50% (diarrhea 30%, HFS and
mucitis 10% each). Three patients (30%) received erlotinib + bevacizumab as a further line after CABO.
Conclusions: In a context of lacking definitive evidences
supporting clinical practice, CABO seems a powerful
option in metastatic HLRCC patients.

H17
Prognostic factors in metastatic
castration resistant prostate
cancer (mCRPC) patients (pts)
treated with Radium 223 (Ra-223): a
retrospective study
Di Stefano R.F.1, Angusti T.1, Parente A.1, Turco F.1, Pisano C.1, Leone
G.1, Samuelly A.1, Vignani F.2, Ortega C.3, Scagliotti G.V.1, Di Maio
M.2, Tucci M.4, Buttigliero C.1
1

A.O.U. San Luigi Gonzaga, Orbassano; 2A.O. Ordine Mauriziano, Torino;
Ospedale San Lazzaro ASL CN2 Alba-Bra, Cuneo; 4Ospedale Cardinal
Massaia, Asti

3

Background: Ra-223 (Ra-223) improved overall survival
(OS) in mCRPC pts. Our study aims to identify baseline
prognostic factors that affect OS in mCRPC pts treated
with Ra-223.
Methods: All CRPC pts treated with Ra-223 at Orbassano
Hospital were included in this retrospective study. Data
about demographics, ECOG PS, number and site of bone
metastasis (mets), lymph node (LN) involvement, local
treatment for prostate cancer (PC), previous treatments,
number of Ra-223 doses, cell blood count, PSA, ALP,
albumin, LDH, bone protecting agents use (BPA), analgesic use and survival were collected. OS was estimated by
Kaplan Meier (log-rank) analysis.
Results: Seventy-five men received Ra-223 between
September 2013 and December 2019, median age was 73
years (range 48-87). Thirty-four (45.3%) had ECOG PS 0,
41 (54.7%) PS 1-2. Median radium doses was 5 (range
1-8). 47 (62.7%) have received previous chemotherapy
and 55 (73.3%) new hormonal agents. 34 (45.43%) had
⩽20 bone mets and 41 (54.7%) >20. LN involvement (<3
cm) was detected in 23 pts (30.7%). 62 (82.7%) received
BPA. 20 pts (26.7) had not received local treatment for PC.
Median baseline laboratory results were: PSA 78.55 ng/ml
(range: 1.33-3489), hemoglobin 12.2 g/dl (9.4-15.8), albumin 3428 g/L (2516-5400), ALP 174 U/L (38-3769), LDH
262 U/L (147-1062). 24 pts (32%) stopped treatment due
to toxicity, 13 (17.3%) to progression and 33 (44%) completed treatment. In the whole series, median OS was 11.15
months (95%CI 9.54 - 12.76), with different prognosis
according to number of previous lines for CRPC: median
OS was 15.99, 14.61, 11.45 and 9.61 months in pts receiving radium as 1st, 2nd, 3nd and 4th /further line, respectively. On univariate analysis LN involvement (yes vs no,

Tumori Journal 106(2S)
HR 1.68, 95%CI 1.01-2.80, p=0.047), absence of local
treatment on primary tumor (HR 1.93, 95%CI 1.13-3.29,
p=0.016), baseline analgesic use (HR 1.82 95%CI 1.083.06, p=0.024), platelets to lymphocyte ratio (PLR) (high
vs low, HR 1.91, 95%CI 1.06-3.45, p=0.03), baseline ALP
(high vs low, HR1.81, 95%CI 1.10-2.99, p=0.019) and
baseline LDH (high vs low, HR 3.86 (95%CI 2.01-7.41),
p<0.001) were significantly associated with worst OS.
Conclusions: Baseline ALP, LDH, analgesic use, PLR,
LN involvement and treatment on primary site are associated with different OS. Pending validation also in external
series, these factors could be used to identify patients most
likely to benefit from Ra-223.

H18
Predictors of outcome in
metastatic renal cell carcinoma
patients treated with Nivolumab
plus Ipilimumab: focus on
inflammatory laboratory
markers
Paolieri F.1, Sbrana A.1, Bloise F.1, Sammarco E.1, Nuzzo A.1,
Manacorda S.1, Bazzurri S.1, Manfredi F.1, Mercinelli C.1, Antonuzzo
A.2, Cianci C.2, Falcone A.1, Galli L.1
1
Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina
e Chirurgia, Università di Pisa, Pisa; 2Azienda Ospedaliero-Universitaria
Pisana, Pisa

Background: Nivolumab plus Ipilimumab (N+I) is a new
standard of care for patients (pts) with not-pretreated intermediate- (IR) and poor-risk (PR) metastatic renal cell carcinoma (mRCC). So far there are no validated predictive
biomarkers in this population.
Material (Patients) and Methods: We have prospectively
collected blood samples of pts starting a treatment with
N+I for mRCC since May 2019. For each patient we collected efficacy and tolerability data and evaluated several
baseline laboratory Parameters, that included: complete
blood count, reticulocyte count, C-reactive protein (CRP),
erythrocyte sedimentation rate (ESR), lactate dehydrogenase, alkaline phosphatase, albumin, corrected calcemia,
transferrin, ferritin, fibrinogen, TSH, fT3, and fT4. We
analysed median progression-free survival (mPFS) and
overall survival (mOS) in the general population and in the
IR and PR subgroups with Kaplan-Meier method. We then
performed regression analysis in order to highlight correlation between baseline laboratory parameters and clinical
outcome.
Results: 14 pts were included in the analysis (7 IR, 7 PR).
At the time of the analysis 7 pts progressed and 4 died.
mPFS was 3.43 months (mos) (95%CI 2.23-7.93) in the
general population: mPFS was not reached in the IR group,
whereas it was 2.37 mos (95%CI 2.07-7.93) in the PR



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
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