Tumori Journal Abstract Book - October 2020 - 142

142	
with longer follow-up, according to CABO-related response
biomarkers and histology will be presented.

H10
Psychological and sexual impacts
of testicular cancer diagnosis:
an exploratory study
Ottaviano M.1, Condello C.2, Tortora M.3, Dolce P.4, De Giorgi U.5,
De Padova S.6, Facchini G.7, Tommaselli S.8, Riccio V.9, Parola S.9,
Picozzi F.9, De Placido P.9, Marretta A.L.9, Vaia A.9, Botti G.8, Daniele
B.1, De Placido S.10, Giuliano M.10, Palmieri G.3
1

Oncology Unit, Ospedale del Mare, Naples, Italy, Napoli; 2Department of
Clinical Medicine and Surgery, Oncology Unit, University of Naples Federico
II, Naples, Italy, Napoli; 3CRCTR Rare Tumors Reference Center of Campania
region, Naples, Italy, Napoli; 4Università degli studi di Napoli "Federico II",
Department of Public Health, Napoli; 5Istituto Scientifico Romagnolo per
lo studio e la Cura dei Tumori IRST IRCCS, Meldola, Italy, Napoli; 6PsychoOncology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei
Tumori (IRST), IRCCS, Meldola, Italy, Napoli; 7Direzione Scientifica, Istituto
Nazionale Tumori, IRCCS, "Fondazione G. Pascale", Naples, Italy., Napoli;
8
Istituto Nazionale Tumori, IRCCS "Fondazione G. Pascale", Naples, Italy,
Napoli; 9Department of Clinical Medicine and Surgery, University of Naples
Federico II, Naples, Italy, Napoli; 10Department of Clinical Medicine and
Surgeryand CRCTR Rare Tumors Reference Center of Campania region,
University of Naples Federico II, Naples, Italy, Napoli

Background: In Western countries Testicular Cancer (TC)
is the most common solid tumor in young men aged between
15 and 40 years. The existential challenge of receiving a life
threatening diagnosis at a young age may cause considerable psychological distress. Indeed, the TC diagnosis triggers
off long-term consequences, including coping with adverse
events, decreased quality of life (QoL), and often a reduced
ability to work and a less active social life. The aim of this
study was to evaluate the impact of TC diagnosis on the psychological and sexual sphere of patients aged > 18 years.
Methods: This was a multi-center prospective study conducted from January 2014 to June 2019. All data were collected at three time-points (TP): first TP at TC diagnosis,
second TP at 3 months from treatment start, third TP at 6
months from treatment end. The following questionnaires
were administered to TC patients (TCP) at each TP:
International Index of Erectile Function (I.I.E.F.); Hospital
Anxiety and Depression Scale (HAD'S); EORTC QLQC30 version 3.0 plus the EORTC QLQ-TC26 Sheet; MiniMAC (Mini Mental Adjustment to Cancer). Statistical
analysis using R (R Core Team, 2018) and lme4 tests
(Bates et al., 2015) were used to find differences between
two groups of TCP (Stage I vs Stage II-III and Surveillance
vs Chemotherapy) over time (1TP-2TP-3TP).
Results: 102 TCP were enrolled. Regarding differences
between Surveillance vs Chemotherapy: the effect of desperation (DE) on depression (D) was positive and significant (b = 0.145, p <0.001), but constant over time (COT),
as well as the effect of anxious concern (AC) on D
(b = 0.107, p <0.001). The effect of erectile function (EF)

Tumori Journal 106(2S)
on anxiety (A), on D and on DE was negative and significant, but COT (b = -0.069, p = 0.002; b = -0.091, p
<0.001; b = -0.090, p <0.016, respectively). Regarding
differences between Stage I vs Stage II-III: the effect of A
on General Health Status (GHS) increased significantly
over time (b = 0.627, p = 0.035); the effect of D on GHS
was positive and significant (b = 0.761, p = 0.032), but
COT. The effect of AC on the GHS was negative and significant (b = -0.687, p <0.001), but COT.
Conclusions: This is the first study to analyse TC diagnosis impact on psychological and sexual sphere, over time.
Our data suggest that the experience of TC has an impact
on adaptation, psychological distress, sexual functioning
and QoL, in relation to the phase of TCP taking charge and
to the delivered treatments.

H11
Plasma tumor DNA as early
predictive biomarker in metastatic
castration-resistant prostate
cancer
Casadei C.1, Conteduca V.1, Wetterskog D.2, Scarpi E.1, Romanel A.3,
Gurioli G.1, Jayaram A.2, Lolli C.1, Gasi Tandefelt D.4, Schepisi G.1,
Wingate A.2, Matteucci F.1, Paganelli G.1, Gonzalez-Billalabeitia E.5,
Demichelis F.3, Attard G.2, De Giorgi U.1
1
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
IRCCS, Meldola; 2University College London Cancer Institute, London;
3
Department of Cellular, Computational and Integrative Biology, University
of Trento, Trento; 4Department of Urology, Sahlgrenska Academy, University
of Gothenburg, Gothenburg; 5Hospital Universitario Morales Meseguer-IMIB
and UCAM, Murcia

Background: Plasma tumour DNA (ptDNA) levels are a
promising minimally-invasive biomarker potentially useful
to measure treatment efficacy in several types of cancers.
However, in prostate cancer there is an urgent need to determine the potential predictive role of ptDNA monitoring.
Here we analyzed on-treatment ptDNA variations and investigated its potential association with treatment outcomes for
metastatic castration-resistant prostate cancer (mCRPC).
Methods: Between 2011 and 2016, we prospectively
included 43 mCRPC abiraterone-treated patients, performing targeted next-generation sequencing on 114 sequential
plasma samples, to evaluate ptDNA fraction. The primary
endpoint was to determine the role of ptDNA fraction
changes and radiographic/biochemical response at 3 month
therapy. ptDNA progression was defined as any increase in
the fraction compared to the baseline.
Results: A rise in ptDNA levels in the first on-treatment
sample (interquartile range (IQR) 2.6-3.7 months) was significantly associated with increased risk of early radiographic progression or prostate-specific antigen (PSA) rise
(OR=15.8, 95%CI 3.5-60.2, p=0.0002 and OR=6.0, 95%CI
1.6-20.0, p=0.01, respectively). We also observed exemplar
cases that had an increase in PSA or pseudo-progression due



Tumori Journal Abstract Book - October 2020

Table of Contents for the Digital Edition of Tumori Journal Abstract Book - October 2020

Contents
Tumori Journal Abstract Book - October 2020 - Cover1
Tumori Journal Abstract Book - October 2020 - Cover2
Tumori Journal Abstract Book - October 2020 - I
Tumori Journal Abstract Book - October 2020 - II
Tumori Journal Abstract Book - October 2020 - Contents
Tumori Journal Abstract Book - October 2020 - IV
Tumori Journal Abstract Book - October 2020 - V
Tumori Journal Abstract Book - October 2020 - 1
Tumori Journal Abstract Book - October 2020 - 2
Tumori Journal Abstract Book - October 2020 - 3
Tumori Journal Abstract Book - October 2020 - 4
Tumori Journal Abstract Book - October 2020 - 5
Tumori Journal Abstract Book - October 2020 - 6
Tumori Journal Abstract Book - October 2020 - 7
Tumori Journal Abstract Book - October 2020 - 8
Tumori Journal Abstract Book - October 2020 - 9
Tumori Journal Abstract Book - October 2020 - 10
Tumori Journal Abstract Book - October 2020 - 11
Tumori Journal Abstract Book - October 2020 - 12
Tumori Journal Abstract Book - October 2020 - 13
Tumori Journal Abstract Book - October 2020 - 14
Tumori Journal Abstract Book - October 2020 - 15
Tumori Journal Abstract Book - October 2020 - 16
Tumori Journal Abstract Book - October 2020 - 17
Tumori Journal Abstract Book - October 2020 - 18
Tumori Journal Abstract Book - October 2020 - 19
Tumori Journal Abstract Book - October 2020 - 20
Tumori Journal Abstract Book - October 2020 - 21
Tumori Journal Abstract Book - October 2020 - 22
Tumori Journal Abstract Book - October 2020 - 23
Tumori Journal Abstract Book - October 2020 - 24
Tumori Journal Abstract Book - October 2020 - 25
Tumori Journal Abstract Book - October 2020 - 26
Tumori Journal Abstract Book - October 2020 - 27
Tumori Journal Abstract Book - October 2020 - 28
Tumori Journal Abstract Book - October 2020 - 29
Tumori Journal Abstract Book - October 2020 - 30
Tumori Journal Abstract Book - October 2020 - 31
Tumori Journal Abstract Book - October 2020 - 32
Tumori Journal Abstract Book - October 2020 - 33
Tumori Journal Abstract Book - October 2020 - 34
Tumori Journal Abstract Book - October 2020 - 35
Tumori Journal Abstract Book - October 2020 - 36
Tumori Journal Abstract Book - October 2020 - 37
Tumori Journal Abstract Book - October 2020 - 38
Tumori Journal Abstract Book - October 2020 - 39
Tumori Journal Abstract Book - October 2020 - 40
Tumori Journal Abstract Book - October 2020 - 41
Tumori Journal Abstract Book - October 2020 - 42
Tumori Journal Abstract Book - October 2020 - 43
Tumori Journal Abstract Book - October 2020 - 44
Tumori Journal Abstract Book - October 2020 - 45
Tumori Journal Abstract Book - October 2020 - 46
Tumori Journal Abstract Book - October 2020 - 47
Tumori Journal Abstract Book - October 2020 - 48
Tumori Journal Abstract Book - October 2020 - 49
Tumori Journal Abstract Book - October 2020 - 50
Tumori Journal Abstract Book - October 2020 - 51
Tumori Journal Abstract Book - October 2020 - 52
Tumori Journal Abstract Book - October 2020 - 53
Tumori Journal Abstract Book - October 2020 - 54
Tumori Journal Abstract Book - October 2020 - 55
Tumori Journal Abstract Book - October 2020 - 56
Tumori Journal Abstract Book - October 2020 - 57
Tumori Journal Abstract Book - October 2020 - 58
Tumori Journal Abstract Book - October 2020 - 59
Tumori Journal Abstract Book - October 2020 - 60
Tumori Journal Abstract Book - October 2020 - 61
Tumori Journal Abstract Book - October 2020 - 62
Tumori Journal Abstract Book - October 2020 - 63
Tumori Journal Abstract Book - October 2020 - 64
Tumori Journal Abstract Book - October 2020 - 65
Tumori Journal Abstract Book - October 2020 - 66
Tumori Journal Abstract Book - October 2020 - 67
Tumori Journal Abstract Book - October 2020 - 68
Tumori Journal Abstract Book - October 2020 - 69
Tumori Journal Abstract Book - October 2020 - 70
Tumori Journal Abstract Book - October 2020 - 71
Tumori Journal Abstract Book - October 2020 - 72
Tumori Journal Abstract Book - October 2020 - 73
Tumori Journal Abstract Book - October 2020 - 74
Tumori Journal Abstract Book - October 2020 - 75
Tumori Journal Abstract Book - October 2020 - 76
Tumori Journal Abstract Book - October 2020 - 77
Tumori Journal Abstract Book - October 2020 - 78
Tumori Journal Abstract Book - October 2020 - 79
Tumori Journal Abstract Book - October 2020 - 80
Tumori Journal Abstract Book - October 2020 - 81
Tumori Journal Abstract Book - October 2020 - 82
Tumori Journal Abstract Book - October 2020 - 83
Tumori Journal Abstract Book - October 2020 - 84
Tumori Journal Abstract Book - October 2020 - 85
Tumori Journal Abstract Book - October 2020 - 86
Tumori Journal Abstract Book - October 2020 - 87
Tumori Journal Abstract Book - October 2020 - 88
Tumori Journal Abstract Book - October 2020 - 89
Tumori Journal Abstract Book - October 2020 - 90
Tumori Journal Abstract Book - October 2020 - 91
Tumori Journal Abstract Book - October 2020 - 92
Tumori Journal Abstract Book - October 2020 - 93
Tumori Journal Abstract Book - October 2020 - 94
Tumori Journal Abstract Book - October 2020 - 95
Tumori Journal Abstract Book - October 2020 - 96
Tumori Journal Abstract Book - October 2020 - 97
Tumori Journal Abstract Book - October 2020 - 98
Tumori Journal Abstract Book - October 2020 - 99
Tumori Journal Abstract Book - October 2020 - 100
Tumori Journal Abstract Book - October 2020 - 101
Tumori Journal Abstract Book - October 2020 - 102
Tumori Journal Abstract Book - October 2020 - 103
Tumori Journal Abstract Book - October 2020 - 104
Tumori Journal Abstract Book - October 2020 - 105
Tumori Journal Abstract Book - October 2020 - 106
Tumori Journal Abstract Book - October 2020 - 107
Tumori Journal Abstract Book - October 2020 - 108
Tumori Journal Abstract Book - October 2020 - 109
Tumori Journal Abstract Book - October 2020 - 110
Tumori Journal Abstract Book - October 2020 - 111
Tumori Journal Abstract Book - October 2020 - 112
Tumori Journal Abstract Book - October 2020 - 113
Tumori Journal Abstract Book - October 2020 - 114
Tumori Journal Abstract Book - October 2020 - 115
Tumori Journal Abstract Book - October 2020 - 116
Tumori Journal Abstract Book - October 2020 - 117
Tumori Journal Abstract Book - October 2020 - 118
Tumori Journal Abstract Book - October 2020 - 119
Tumori Journal Abstract Book - October 2020 - 120
Tumori Journal Abstract Book - October 2020 - 121
Tumori Journal Abstract Book - October 2020 - 122
Tumori Journal Abstract Book - October 2020 - 123
Tumori Journal Abstract Book - October 2020 - 124
Tumori Journal Abstract Book - October 2020 - 125
Tumori Journal Abstract Book - October 2020 - 126
Tumori Journal Abstract Book - October 2020 - 127
Tumori Journal Abstract Book - October 2020 - 128
Tumori Journal Abstract Book - October 2020 - 129
Tumori Journal Abstract Book - October 2020 - 130
Tumori Journal Abstract Book - October 2020 - 131
Tumori Journal Abstract Book - October 2020 - 132
Tumori Journal Abstract Book - October 2020 - 133
Tumori Journal Abstract Book - October 2020 - 134
Tumori Journal Abstract Book - October 2020 - 135
Tumori Journal Abstract Book - October 2020 - 136
Tumori Journal Abstract Book - October 2020 - 137
Tumori Journal Abstract Book - October 2020 - 138
Tumori Journal Abstract Book - October 2020 - 139
Tumori Journal Abstract Book - October 2020 - 140
Tumori Journal Abstract Book - October 2020 - 141
Tumori Journal Abstract Book - October 2020 - 142
Tumori Journal Abstract Book - October 2020 - 143
Tumori Journal Abstract Book - October 2020 - 144
Tumori Journal Abstract Book - October 2020 - 145
Tumori Journal Abstract Book - October 2020 - 146
Tumori Journal Abstract Book - October 2020 - 147
Tumori Journal Abstract Book - October 2020 - 148
Tumori Journal Abstract Book - October 2020 - 149
Tumori Journal Abstract Book - October 2020 - 150
Tumori Journal Abstract Book - October 2020 - 151
Tumori Journal Abstract Book - October 2020 - 152
Tumori Journal Abstract Book - October 2020 - 153
Tumori Journal Abstract Book - October 2020 - 154
Tumori Journal Abstract Book - October 2020 - 155
Tumori Journal Abstract Book - October 2020 - 156
Tumori Journal Abstract Book - October 2020 - 157
Tumori Journal Abstract Book - October 2020 - 158
Tumori Journal Abstract Book - October 2020 - 159
Tumori Journal Abstract Book - October 2020 - 160
Tumori Journal Abstract Book - October 2020 - 161
Tumori Journal Abstract Book - October 2020 - 162
Tumori Journal Abstract Book - October 2020 - 163
Tumori Journal Abstract Book - October 2020 - 164
Tumori Journal Abstract Book - October 2020 - 165
Tumori Journal Abstract Book - October 2020 - 166
Tumori Journal Abstract Book - October 2020 - 167
Tumori Journal Abstract Book - October 2020 - 168
Tumori Journal Abstract Book - October 2020 - 169
Tumori Journal Abstract Book - October 2020 - 170
Tumori Journal Abstract Book - October 2020 - 171
Tumori Journal Abstract Book - October 2020 - 172
Tumori Journal Abstract Book - October 2020 - 173
Tumori Journal Abstract Book - October 2020 - 174
Tumori Journal Abstract Book - October 2020 - 175
Tumori Journal Abstract Book - October 2020 - 176
Tumori Journal Abstract Book - October 2020 - 177
Tumori Journal Abstract Book - October 2020 - 178
Tumori Journal Abstract Book - October 2020 - 179
Tumori Journal Abstract Book - October 2020 - 180
Tumori Journal Abstract Book - October 2020 - 181
Tumori Journal Abstract Book - October 2020 - 182
Tumori Journal Abstract Book - October 2020 - 183
Tumori Journal Abstract Book - October 2020 - 184
Tumori Journal Abstract Book - October 2020 - 185
Tumori Journal Abstract Book - October 2020 - 186
Tumori Journal Abstract Book - October 2020 - 187
Tumori Journal Abstract Book - October 2020 - 188
Tumori Journal Abstract Book - October 2020 - 189
Tumori Journal Abstract Book - October 2020 - 190
Tumori Journal Abstract Book - October 2020 - 191
Tumori Journal Abstract Book - October 2020 - 192
Tumori Journal Abstract Book - October 2020 - 193
Tumori Journal Abstract Book - October 2020 - 194
Tumori Journal Abstract Book - October 2020 - 195
Tumori Journal Abstract Book - October 2020 - 196
Tumori Journal Abstract Book - October 2020 - 197
Tumori Journal Abstract Book - October 2020 - 198
Tumori Journal Abstract Book - October 2020 - 199
Tumori Journal Abstract Book - October 2020 - 200
Tumori Journal Abstract Book - October 2020 - 201
Tumori Journal Abstract Book - October 2020 - 202
Tumori Journal Abstract Book - October 2020 - 203
Tumori Journal Abstract Book - October 2020 - 204
Tumori Journal Abstract Book - October 2020 - 205
Tumori Journal Abstract Book - October 2020 - 206
Tumori Journal Abstract Book - October 2020 - 207
Tumori Journal Abstract Book - October 2020 - 208
Tumori Journal Abstract Book - October 2020 - 209
Tumori Journal Abstract Book - October 2020 - 210
Tumori Journal Abstract Book - October 2020 - 211
Tumori Journal Abstract Book - October 2020 - 212
Tumori Journal Abstract Book - October 2020 - 213
Tumori Journal Abstract Book - October 2020 - 214
Tumori Journal Abstract Book - October 2020 - 215
Tumori Journal Abstract Book - October 2020 - 216
Tumori Journal Abstract Book - October 2020 - 217
Tumori Journal Abstract Book - October 2020 - 218
Tumori Journal Abstract Book - October 2020 - 219
Tumori Journal Abstract Book - October 2020 - 220
Tumori Journal Abstract Book - October 2020 - 221
Tumori Journal Abstract Book - October 2020 - 222
Tumori Journal Abstract Book - October 2020 - 223
Tumori Journal Abstract Book - October 2020 - 224
Tumori Journal Abstract Book - October 2020 - 225
Tumori Journal Abstract Book - October 2020 - 226
Tumori Journal Abstract Book - October 2020 - 227
Tumori Journal Abstract Book - October 2020 - 228
Tumori Journal Abstract Book - October 2020 - 229
Tumori Journal Abstract Book - October 2020 - 230
Tumori Journal Abstract Book - October 2020 - 231
Tumori Journal Abstract Book - October 2020 - 232
Tumori Journal Abstract Book - October 2020 - 233
Tumori Journal Abstract Book - October 2020 - 234
Tumori Journal Abstract Book - October 2020 - 235
Tumori Journal Abstract Book - October 2020 - Cover3
Tumori Journal Abstract Book - October 2020 - Cover4
https://www.nxtbookmedia.com